메뉴 건너뛰기




Volumn 87, Issue 12, 2009, Pages 1251-1261

Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin

Author keywords

Cyclooxygenase 2; Inducible nitric oxide synthase; NF B; Raw 264.7 cells; TNF

Indexed keywords

BENZYL ISOTHIOCYANATE; CYCLOOXYGENASE 2; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN KINASE B; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

EID: 70949086095     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0532-6     Document Type: Article
Times cited : (53)

References (35)
  • 1
    • 0036484856 scopus 로고    scopus 로고
    • Chronic inflammation and cancer
    • (Williston Park) 229; discussion 230-212
    • Shacter E, Weitzman SA (2002) Chronic inflammation and cancer. Oncology (Williston Park) 16:217-226, 229; discussion 230-212
    • (2002) Oncology , vol.16 , pp. 217-226
    • Shacter, E.1    Weitzman, S.A.2
  • 2
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • DOI 10.1016/S0140-6736(00)04046-0
    • F Balkwill A Mantovani 2001 Inflammation and cancer: back to Virchow? Lancet 357 539 545 10.1016/S0140-6736(00)04046-0 1:CAS:528:DC%2BD3MXhsVKltb0%3D 11229684 (Pubitemid 32173595)
    • (2001) Lancet , vol.357 , Issue.9255 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 3
    • 34250836890 scopus 로고    scopus 로고
    • COX-2: Friend or foe?
    • DOI 10.2174/138161207780831293
    • A Iezzi C Ferri A Mezzetti F Cipollone 2007 COX-2: friend or foe? Curr Pharm Des 13 1715 1721 10.2174/138161207780831293 1:CAS:528:DC%2BD2sXntVOiu7k%3D 17584101 (Pubitemid 46979725)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.16 , pp. 1715-1721
    • Iezzi, A.1    Ferri, C.2    Mezzetti, A.3    Cipollone, F.4
  • 4
    • 0030937832 scopus 로고    scopus 로고
    • Nitric oxide and macrophage function
    • DOI 10.1146/annurev.immunol.15.1.323
    • J MacMicking QW Xie C Nathan 1997 Nitric oxide and macrophage function Annu Rev Immunol 15 323 350 10.1146/annurev.immunol.15.1.323 1:CAS:528:DyaK2sXisVCmsLo%3D 9143691 (Pubitemid 27169284)
    • (1997) Annual Review of Immunology , vol.15 , pp. 323-350
    • MacMicking, J.1    Xie, Q.-W.2    Nathan, C.3
  • 5
    • 66349127141 scopus 로고    scopus 로고
    • Cyclooxygenases: Structural and functional insights
    • 10.1194/jlr.R800042-JLR200 18952571
    • CA Rouzer LJ Marnett 2009 Cyclooxygenases: structural and functional insights J Lipid Res 50 Suppl S29 S34 10.1194/jlr.R800042-JLR200 18952571
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL
    • Rouzer, C.A.1    Marnett, L.J.2
  • 6
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • DOI 10.1042/0264-6021:3570593
    • WK Alderton CE Cooper RG Knowles 2001 Nitric oxide synthases: structure, function and inhibition Biochem J 357 593 615 10.1042/0264-6021:3570593 1:CAS:528:DC%2BD3MXmtFent70%3D 11463332 (Pubitemid 32735142)
    • (2001) Biochemical Journal , vol.357 , Issue.3 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 7
    • 35648941579 scopus 로고    scopus 로고
    • Targeting NOX, INOS and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals
    • DOI 10.1002/ijc.23161
    • A Murakami H Ohigashi 2007 Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals Int J Cancer 121 2357 2363 10.1002/ijc.23161 1:CAS:528:DC%2BD2sXhtlShtb7L 17893865 (Pubitemid 350022403)
    • (2007) International Journal of Cancer , vol.121 , Issue.11 , pp. 2357-2363
    • Murakami, A.1    Ohigashi, H.2
  • 8
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    • 10.1038/nrd2781 1:CAS:528:DC%2BD1cXhsFCku7%2FM 19116625
    • V Baud M Karin 2009 Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls Nat Rev Drug Discov 8 33 40 10.1038/nrd2781 1:CAS:528: DC%2BD1cXhsFCku7%2FM 19116625
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 9
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • DOI 10.1146/annurev.immunol.18.1.621
    • M Karin Y Ben-Neriah 2000 Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity Annu Rev Immunol 18 621 663 10.1146/annurev. immunol.18.1.621 1:CAS:528:DC%2BD3cXjs1Gmtro%3D 10837071 (Pubitemid 30365393)
    • (2000) Annual Review of Immunology , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 10
    • 33746862576 scopus 로고    scopus 로고
    • Naturally occurring NF-κB inhibitors
    • DOI 10.2174/138955706777934937
    • NH Nam 2006 Naturally occurring NF-kappaB inhibitors Mini Rev Med Chem 6 945 951 10.2174/138955706777934937 1:CAS:528:DC%2BD28XnslOksrw%3D 16918500 (Pubitemid 44194381)
    • (2006) Mini-Reviews in Medicinal Chemistry , vol.6 , Issue.8 , pp. 945-951
    • Nam, N.-H.1
  • 11
    • 34047136753 scopus 로고    scopus 로고
    • Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
    • DOI 10.1016/j.phrs.2007.01.009, PII S1043661807000321, Nutritional Pharmacology
    • JV Higdon B Delage DE Williams RH Dashwood 2007 Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis Pharmacol Res 55 224 236 10.1016/j.phrs.2007.01.009 1:CAS:528:DC%2BD2sXjvFGnt7c%3D 17317210 (Pubitemid 46518152)
    • (2007) Pharmacological Research , vol.55 , Issue.3 , pp. 224-236
    • Higdon, J.V.1    Delage, B.2    Williams, D.E.3    Dashwood, R.H.4
  • 12
    • 0029047391 scopus 로고
    • Chemoprevention by isothiocyanates
    • 10.1002/jcb.240590825 1:STN:280:DyaK28%2FhtVegsA%3D%3D 8538199
    • SS Hecht 1995 Chemoprevention by isothiocyanates J Cell Biochem Suppl 22 195 209 10.1002/jcb.240590825 1:STN:280:DyaK28%2FhtVegsA%3D%3D 8538199
    • (1995) J Cell Biochem Suppl , vol.22 , pp. 195-209
    • Hecht, S.S.1
  • 13
    • 33645303201 scopus 로고    scopus 로고
    • Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: Potential for chemoprevention in smokers
    • 10.1093/carcin/bgi301
    • LB von Weymarn JA Chun PF Hollenberg 2006 Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers Carcinogenesis 27 782 790 10.1093/carcin/bgi301
    • (2006) Carcinogenesis , vol.27 , pp. 782-790
    • Von Weymarn, L.B.1    Chun, J.A.2    Hollenberg, P.F.3
  • 14
    • 16444376996 scopus 로고    scopus 로고
    • Benzyl isothiocyanate inhibits oxidative stress in mouse skin: Involvement of attenuation of leukocyte infiltration
    • 10.1002/biof.552210149 1:CAS:528:DC%2BD2cXhtFGnsrjM 15630206
    • Y Nakamura N Miyoshi S Takabayashi T Osawa 2004 Benzyl isothiocyanate inhibits oxidative stress in mouse skin: involvement of attenuation of leukocyte infiltration Biofactors 21 255 257 10.1002/biof.552210149 1:CAS:528: DC%2BD2cXhtFGnsrjM 15630206
    • (2004) Biofactors , vol.21 , pp. 255-257
    • Nakamura, Y.1    Miyoshi, N.2    Takabayashi, S.3    Osawa, T.4
  • 15
    • 10344230716 scopus 로고    scopus 로고
    • Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: Implication for prevention against inflammation-related carcinogenesis
    • DOI 10.1093/carcin/bgh051
    • N Miyoshi S Takabayashi T Osawa Y Nakamura 2004 Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis Carcinogenesis 25 567 575 10.1093/carcin/bgh051 1:CAS:528:DC%2BD2cXisF2ltLs%3D 14688023 (Pubitemid 38499945)
    • (2004) Carcinogenesis , vol.25 , Issue.4 , pp. 567-575
    • Miyoshi, N.1    Takabayashi, S.2    Osawa, T.3    Nakamura, Y.4
  • 17
    • 38149133012 scopus 로고    scopus 로고
    • 3,3′-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages
    • 1:CAS:528:DC%2BD1cXktVSlug%3D%3D 18156398
    • HJ Cho MR Seon YM Lee J Kim JK Kim SG Kim JH Park 2008 3,3′-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages J Nutr 138 17 23 1:CAS:528: DC%2BD1cXktVSlug%3D%3D 18156398
    • (2008) J Nutr , vol.138 , pp. 17-23
    • Cho, H.J.1    Seon, M.R.2    Lee, Y.M.3    Kim, J.4    Kim, J.K.5    Kim, S.G.6    Park, J.H.7
  • 18
    • 33646451673 scopus 로고    scopus 로고
    • Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells
    • 10.1248/bpb.29.985 1:CAS:528:DC%2BD28Xmt1ehtLs%3D 16651732
    • YM Park JH Won KJ Yun JH Ryu YN Han SK Choi KT Lee 2006 Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells Biol Pharm Bull 29 985 990 10.1248/bpb.29.985 1:CAS:528:DC%2BD28Xmt1ehtLs%3D 16651732
    • (2006) Biol Pharm Bull , vol.29 , pp. 985-990
    • Park, Y.M.1    Won, J.H.2    Yun, K.J.3    Ryu, J.H.4    Han, Y.N.5    Choi, S.K.6    Lee, K.T.7
  • 19
    • 27544447259 scopus 로고    scopus 로고
    • Repression by oxidative stress of iNOS and cytokine gene induction in macrophages results from AP-1 and NF-κB inhibition mediated by B cell translocation gene-1 activation
    • DOI 10.1016/j.freeradbiomed.2005.07.017, PII S0891584905004417
    • IJ Cho AK Lee SJ Lee MG Lee SG Kim 2005 Repression by oxidative stress of iNOS and cytokine gene induction in macrophages results from AP-1 and NF-kappaB inhibition mediated by B cell translocation gene-1 activation Free Radic Biol Med 39 1523 1536 10.1016/j.freeradbiomed.2005.07.017 1:CAS:528: DC%2BD2MXhtFyksLjI 16274887 (Pubitemid 41547232)
    • (2005) Free Radical Biology and Medicine , vol.39 , Issue.11 , pp. 1523-1536
    • Il, J.C.1    Ae, K.L.2    Song, J.L.3    Myung, G.L.4    Kim, S.G.5
  • 20
    • 0032980125 scopus 로고    scopus 로고
    • Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism
    • 1:CAS:528:DyaK1MXhvFalsL8%3D 10082787
    • SS Hecht 1999 Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism J Nutr 129 768S 774S 1:CAS:528:DyaK1MXhvFalsL8%3D 10082787
    • (1999) J Nutr , vol.129
    • Hecht, S.S.1
  • 21
    • 0038059372 scopus 로고    scopus 로고
    • Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-γ-induced IκB degradation in RAW264.7 macrophages
    • DOI 10.1016/S0304-3835(03)00058-2
    • A Murakami K Matsumoto K Koshimizu H Ohigashi 2003 Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages Cancer Lett 195 17 25 10.1016/S0304-3835(03)00058-2 1:CAS:528:DC%2BD3sXktFWmsLg%3D 12767507 (Pubitemid 36588974)
    • (2003) Cancer Letters , vol.195 , Issue.1 , pp. 17-25
    • Murakami, A.1    Matsumoto, K.2    Koshimizu, K.3    Ohigashi, H.4
  • 22
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB - A pivotal transcription factor in chronic inflammatory diseases
    • DOI 10.1056/NEJM199704103361506
    • PJ Barnes M Karin 1997 Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases N Engl J Med 336 1066 1071 10.1056/NEJM199704103361506 1:CAS:528:DyaK2sXis1SrsLw%3D 9091804 (Pubitemid 27163860)
    • (1997) New England Journal of Medicine , vol.336 , Issue.15 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 23
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • DOI 10.1038/nri910
    • Q Li IM Verma 2002 NF-kappaB regulation in the immune system Nat Rev Immunol 2 725 734 10.1038/nri910 1:CAS:528:DC%2BD38XnsVGqsbg%3D 12360211 (Pubitemid 37328713)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.10 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 24
    • 0034190367 scopus 로고    scopus 로고
    • Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB
    • DOI 10.1016/S0891-5849(00)00218-5, PII S0891584900002185
    • YM Janssen-Heininger ME Poynter PA Baeuerle 2000 Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB Free Radic Biol Med 28 1317 1327 10.1016/S0891-5849(00)00218-5 1:CAS:528: DC%2BD3cXltlWgtLg%3D 10924851 (Pubitemid 30621476)
    • (2000) Free Radical Biology and Medicine , vol.28 , Issue.9 , pp. 1317-1327
    • Janssen-Heininger, Y.M.W.1    Poynter, M.E.2    Baeuerle, P.A.3
  • 25
    • 0032925361 scopus 로고    scopus 로고
    • Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-γ
    • DOI 10.1086/314659
    • SJ Ajizian BK English EA Meals 1999 Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma J Infect Dis 179 939 944 10.1086/314659 1:CAS:528:DyaK1MXitlSls7g%3D 10068590 (Pubitemid 29159340)
    • (1999) Journal of Infectious Diseases , vol.179 , Issue.4 , pp. 939-944
    • Ajizian, S.J.1    English, B.K.2    Meals, E.A.3
  • 26
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • 1:CAS:528:DyaK1cXht12jtbo%3D 9464988
    • NR Bhat P Zhang JC Lee EL Hogan 1998 Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures J Neurosci 18 1633 1641 1:CAS:528:DyaK1cXht12jtbo%3D 9464988
    • (1998) J Neurosci , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 28
    • 42149110310 scopus 로고    scopus 로고
    • Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells
    • 1:CAS:528:DC%2BD1cXhsVSht7s%3D 18250410
    • K Tsukamoto K Hazeki M Hoshi K Nigorikawa N Inoue T Sasaki O Hazeki 2008 Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells J Immunol 180 2054 2061 1:CAS:528: DC%2BD1cXhsVSht7s%3D 18250410
    • (2008) J Immunol , vol.180 , pp. 2054-2061
    • Tsukamoto, K.1    Hazeki, K.2    Hoshi, M.3    Nigorikawa, K.4    Inoue, N.5    Sasaki, T.6    Hazeki, O.7
  • 29
    • 53149131317 scopus 로고    scopus 로고
    • Inhibitory effect of 30-kDa phytoglycoprotein on expression of TNF-alpha and COX-2 via activation of PKCalpha and ERK 1/2 in LPS-stimulated RAW 264.7 cells
    • 10.1007/s11010-008-9843-0 1:CAS:528:DC%2BD1cXhtFCnsrrK 18566751
    • SJ Lee KT Lim 2008 Inhibitory effect of 30-kDa phytoglycoprotein on expression of TNF-alpha and COX-2 via activation of PKCalpha and ERK 1/2 in LPS-stimulated RAW 264.7 cells Mol Cell Biochem 317 151 159 10.1007/s11010-008- 9843-0 1:CAS:528:DC%2BD1cXhtFCnsrrK 18566751
    • (2008) Mol Cell Biochem , vol.317 , pp. 151-159
    • Lee, S.J.1    Lim, K.T.2
  • 30
    • 44749089457 scopus 로고    scopus 로고
    • Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells
    • 10.1016/j.fct.2008.03.016 1:CAS:528:DC%2BD1cXmvVKqtb8%3D 18502015
    • ES Hwang HJ Lee 2008 Benzyl isothiocyanate inhibits metalloproteinase-2/- 9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells Food Chem Toxicol 46 2358 2364 10.1016/j.fct.2008.03.016 1:CAS:528:DC%2BD1cXmvVKqtb8%3D 18502015
    • (2008) Food Chem Toxicol , vol.46 , pp. 2358-2364
    • Hwang, E.S.1    Lee, H.J.2
  • 31
    • 0033519453 scopus 로고    scopus 로고
    • Induction of NF-κB by the Akt/PKB kinase
    • DOI 10.1016/S0960-9822(99)80265-6
    • LP Kane VS Shapiro D Stokoe A Weiss 1999 Induction of NF-kappaB by the Akt/PKB kinase Curr Biol 9 601 604 10.1016/S0960-9822(99)80265-6 1:CAS:528:DyaK1MXjvVeks7w%3D 10359702 (Pubitemid 29273109)
    • (1999) Current Biology , vol.9 , Issue.11 , pp. 601-604
    • Kane, L.P.1    Shapiro, V.S.2    Stokoe, D.3    Weiss, A.4
  • 32
    • 0037119428 scopus 로고    scopus 로고
    • Akt is a downstream target of NF-kappa B
    • 10.1074/jbc.M112464200 1:CAS:528:DC%2BD38XmsVKitbs%3D 12052823
    • F Meng L Liu PC Chin SR D'Mello 2002 Akt is a downstream target of NF-kappa B J Biol Chem 277 29674 29680 10.1074/jbc.M112464200 1:CAS:528:DC%2BD38XmsVKitbs%3D 12052823
    • (2002) J Biol Chem , vol.277 , pp. 29674-29680
    • Meng, F.1    Liu, L.2    Chin, P.C.3    D'Mello, S.R.4
  • 33
    • 33645988531 scopus 로고    scopus 로고
    • Inflammation in epithelial skin tumours: Old stories and new ideas
    • 10.1016/j.ejca.2006.01.014 1:CAS:528:DC%2BD28Xjs1Grt7s%3D 16527478
    • MM Mueller 2006 Inflammation in epithelial skin tumours: old stories and new ideas Eur J Cancer 42 735 744 10.1016/j.ejca.2006.01.014 1:CAS:528:DC%2BD28Xjs1Grt7s%3D 16527478
    • (2006) Eur J Cancer , vol.42 , pp. 735-744
    • Mueller, M.M.1
  • 34
    • 48249149426 scopus 로고    scopus 로고
    • TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: A novel in vivo screening model of psoriasis
    • 10.1093/intimm/dxn068 1:CAS:528:DC%2BD1cXptVenuro%3D 18579711
    • H Hvid I Teige PH Kvist L Svensson K Kemp 2008 TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis Int Immunol 20 1097 1106 10.1093/intimm/dxn068 1:CAS:528: DC%2BD1cXptVenuro%3D 18579711
    • (2008) Int Immunol , vol.20 , pp. 1097-1106
    • Hvid, H.1    Teige, I.2    Kvist, P.H.3    Svensson, L.4    Kemp, K.5
  • 35
    • 54049155122 scopus 로고    scopus 로고
    • Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice
    • 10.1111/j.1600-0625.2008.00737.x 1:CAS:528:DC%2BD1cXhsVGgt7bL 18721197
    • JS Kang WK Yoon JK Youm SK Jeong BD Park MH Han H Lee EY Moon SB Han CW Lee K Lee SK Park KH Yang HM Kim 2008 Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice Exp Dermatol 17 958 964 10.1111/j.1600-0625.2008.00737.x 1:CAS:528:DC%2BD1cXhsVGgt7bL 18721197
    • (2008) Exp Dermatol , vol.17 , pp. 958-964
    • Kang, J.S.1    Yoon, W.K.2    Youm, J.K.3    Jeong, S.K.4    Park, B.D.5    Han, M.H.6    Lee, H.7    Moon, E.Y.8    Han, S.B.9    Lee, C.W.10    Lee, K.11    Park, S.K.12    Yang, K.H.13    Kim, H.M.14


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.