NF-κB p65 and c-Rel subunits promote phagocytosis and cytokine secretion by splenic macrophages in cirrhotic patients with hypersplenism

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 2, 2013, Pages 335-343

  Ren, Song ^a   Zhang, Shu ^a   Li, Manxiang ^a   Huang, Chen ^a   Liang, Rongrui ^a   Jiang, An ^a   Guo, Yanfeng ^a   Pu, Yansong ^a   Huang, Na ^a   Yang, Jun ^a   Li, Zongfang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Cytokine secretion; Hypersplenism; Liver cirrhosis; Nuclear factor kappa B (NF B); Phagocytosis; Splenic macrophage

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; NF KAPPA B C REL SUBUNIT; NUCLEIC ACID BINDING PROTEIN; PROTEIN P52; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONFOCAL MICROSCOPE; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE SILENCING; GENETIC TRANSFECTION; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; HYPERSPLENISM; LIVER CIRRHOSIS; MACROPHAGE; MALE; PHAGOCYTOSIS; PROTEIN ANALYSIS; SPLEEN CELL; WESTERN BLOTTING;

ADULT; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HEPATITIS B; HEPATITIS C; HUMANS; HYPERSPLENISM; LIVER CIRRHOSIS; MACROPHAGES; MALE; MIDDLE AGED; PHAGOCYTOSIS; PHENYLENEDIAMINES; PROTO-ONCOGENE PROTEINS C-REL; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR RELA; YOUNG ADULT;

EID: 84872285285     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.11.012     Document Type: Article

References (36)

1. T. Akahoshi, M. Hashizume, K. Tanoue, R. Shimabukuro, N. Gotoh, and M. Tomikawa Role of the spleen in liver fibrosis in rats may be mediated by transforming growth factor beta-1 Journal of Gastroenterology and Hepatology 17 2002 59 65
2. R.H. Aster Pooling of platelets in the spleen: role in the pathogenesis of hypersplenic thrombocytopenia Journal of Clinical Investigation 45 1966 645 657
3. F.N. Bashour, J.C. Teran, and K.D. Mullen Prevalence of peripheral blood cytopenias (hypersplenism) in patients with nonalcoholic chronic liver disease American Journal of Gastroenterology 95 2000 2936 2939
4. R. Bataller, and D.A. Brenner Liver fibrosis Journal of Clinical Investigation 115 2005 209 218
5. A. Chan, T. Magnus, and R. Gold Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: mechanism for removal of apoptotic cells in the inflamed nervous system Glia 33 2001 87 95
6. J.P. Cogswell, M.M. Godlevski, G.B. Wisely, W.C. Clay, L.M. Leesnitzer, and J.P. Ways NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site Journal of Immunology 153 1994 712 723
7. M.A. Collart, P. Baeuerle, and P. Vassalli Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B Molecular and Cellular Biology 10 1990 1498 1506
8. R. Fernandez-Boyanapalli, K.A. McPhillips, S.C. Frasch, W.J. Janssen, M.C. Dinauer, and D.W. Riches Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-gamma in a nitric oxide-dependent manner Journal of Immunology 185 2010 4030 4041
9. M.C. Gerbod-Giannone, Y. Li, A. Holleboom, S. Han, L.C. Hsu, and I. Tabas TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells Proceedings of the National Academy of Sciences of the United States of America 103 2006 3112 3117
10. G. Grigoriadis, Y. Zhan, R.J. Grumont, D. Metcalf, E. Handman, and C. Cheers The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations EMBO Journal 15 1996 7099 7107
11. Y. Hamon, C. Broccardo, O. Chambenoit, M.F. Luciani, F. Toti, and S. Chaslin ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine Nature Cell Biology 2 2000 399 406
12. Y.P. Han, L. Zhou, J. Wang, S. Xiong, W.L. Garner, and S.W. French Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen Journal of Biological Chemistry 279 2004 4820 4828
13. M.S. Hayden, and S. Ghosh Shared principles in NF-kappaB signaling Cell 132 2008 344 362
14. A. Hoffmann, G. Natoli, and G. Ghosh Transcriptional regulation via the NF-kappaB signaling module Oncogene 25 2006 6706 6716
15. M. Kajihara, S. Kato, Y. Okazaki, Y. Kawakami, H. Ishii, and Y. Ikeda A role of autoantibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis Hepatology 37 2003 1267 1276
16. N. Kubica, J.L. Crispino, J.W. Gallagher, S.R. Kimball, and L.S. Jefferson Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis International Journal of Biochemistry and Cell Biology 40 2008 2522 2533
17. T. Lawrence, D.W. Gilroy, P.R. Colville-Nash, and D.A. Willoughby Possible new role for NF-kappaB in the resolution of inflammation Nature Medicine 7 2001 1291 1297
18. K.Y. Lee, K. Ito, R. Hayashi, E.P. Jazrawi, P.J. Barnes, and I.M. Adcock NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription Journal of Immunology 176 2006 603 615
19. A. Li, Z. Li, S. Ma, Q. Su, S. Zhang, and X. Sun Dysfunction of splenic macrophages in cirrhotic patients with hypersplenism and HBV infection American Journal of the Medical Sciences 336 2008 32 38
20. H.C. Liou, and C.Y. Hsia Distinctions between c-Rel and other NF-kappa B proteins in immunity and disease Bioessays 25 2003 767 780
21. S.J. Lolait, A.T. Lim, B.H. Toh, and J.W. Funder Immunoreactive beta-endorphin in a subpopulation of mouse spleen macrophages Journal of Clinical Investigation 73 1984 277 280
22. N. Mori, and D. Prager Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins Blood 87 1996 3410 3417
23. T. Nakamura, R. Sakata, T. Ueno, M. Sata, and H. Ueno Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats Hepatology 32 2000 247 255
24. Y. Ren, and J. Savill Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis Journal of Immunology 154 1995 2366 2374
25. A. Sanchez, A.M. Alvarez, M. Benito, and I. Fabregat Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates Journal of Biological Chemistry 271 1996 7416 7422
26. S. Sanjabi, A. Hoffmann, H.C. Liou, D. Baltimore, and S.T. Smale Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages Proceedings of the National Academy of Sciences of the United States of America 97 2000 12705 12710
27. D. Schuppan, and N.H. Afdhal Liver cirrhosis Lancet 371 2008 838 851
28. S.H. Shah, P.C. Hayes, P.L. Allan, J. Nicoll, and N.D. Finlayson Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis American Journal of Gastroenterology 91 1996 2580 2583
29. A. Sica, L. Dorman, V. Viggiano, M. Cippitelli, P. Ghosh, and N. Rice Interaction of NF-kappaB and NFAT with the interferon-gamma promoter Journal of Biological Chemistry 272 1997 30412 30420
30. S.T. Smale Hierarchies of NF-kappaB target-gene regulation Nature Immunology 12 2011 689 694
31. C.C. Taggart, S.A. Cryan, S. Weldon, A. Gibbons, C.M. Greene, and E. Kelly Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding Journal of Experimental Medicine 202 2005 1659 1668
32. A.M. Tiggelman, W. Boers, C. Linthorst, M. Sala, and R.A. Chamuleau Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1 beta, IL-4, TGF beta and IFN gamma Journal of Hepatology 23 1995 307 317
33. A.M. Timmer, and V. Nizet IKKbeta/NF-kappaB and the miscreant macrophage Journal of Experimental Medicine 205 2008 1255 1259
34. M. Tomikawa, M. Hashizume, T. Akahoshi, R. Shimabukuro, N. Gotoh, and M. Ohta Effects of splenectomy on liver volume and prognosis of cirrhosis in patients with esophageal varices Journal of Gastroenterology and Hepatology 17 2002 77 80
35. W. Yongxiang, L. Zongfang, L. Guowei, J. Zongzheng, C. Xi, and W. Tao Effects of splenomegaly and splenic macrophage activity in hypersplenism due to cirrhosis American Journal of Medicine 113 2002 428 431
36. W. Zhang, S. Zhang, Z.F. Li, C. Huang, S. Ren, and R. Zhou Knockdown of PIK3R1 by shRNA inhibits the activity of the splenic macrophages associated with hypersplenism due to portal hypertension Pathology, Research and Practice 206 2010 760 767