Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

Nature

Volumn 503, Issue 7474, 2013, Pages 126-130

  Gerber, Elizabeth E ^a   Gallo, Elena M ^a   Fontana, Stefani C ^a   Davis, Elaine C ^b   Wigley, Fredrick M ^a   Huso, David L ^a   Dietz, Harry C ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; AUTOANTIBODY; FIBRILLIN 1; INTEGRIN; TRANSFORMING GROWTH FACTOR BETA;

AMINO ACID; ANTAGONISM; DISEASE; ETIOLOGY; GENE; PLASMA; SKIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; AUTOSOMAL DOMINANT INHERITANCE; CELL INFILTRATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; HELPER CELL; HETEROZYGOTE; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; MALE; MISSENSE MUTATION; MOLECULAR INTERACTION; MOUSE; MUTANT; NONHUMAN; PENETRANCE; PLASMA CELL; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN MOTIF; SCLERODERMA; SKIN FIBROSIS; WESTERN BLOTTING;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, NEUTRALIZING; AUTOIMMUNITY; CONTRACTURE; DENDRITIC CELLS; FEMALE; FIBROSIS; INTEGRINS; MALE; MICE; MICROFILAMENT PROTEINS; MUTATION, MISSENSE; PLASMA CELLS; SCLERODERMA, SYSTEMIC; SKIN DISEASES, GENETIC; T-LYMPHOCYTES, HELPER-INDUCER; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; MUS;

EID: 84887408112     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12614     Document Type: Article

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