Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

Cancer Letters

Volumn 358, Issue 1, 2015, Pages 47-58

  Wang, Weilin ^a,b   Xie, Qingsong ^c   Zhou, Xiaohu ^c   Yao, Jingzi ^c   Zhu, Xiaoxiang ^c   Huang, Pengfei ^c   Zhang, Lufei ^c   Wei, Jianfeng ^a   Xie, Haiyang ^c   Zhou, Lin ^c   Zheng, Shusen ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c BEIJING HOSPITAL   (China)

Author keywords

Heparin; InsP3R; Mitochondrial Ca2+ uniporter; Mitochondrial calcium uptake 2; Mitochondrial calcium uptake1; RU360

Indexed keywords

CALCIUM ION; CASPASE 3; CELL PROTEIN; CYTOCHROME C; INOSITOL TRISPHOSPHATE RECEPTOR; MITOCHONDRIAL CALCIUM UNIPORTER PROTEIN; MITOCHONDRIAL CALCIUM UPTAKE 1 PROTEIN; MITOCHONDRIAL CALCIUM UPTAKE 2 PROTEIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOFUSIN 2; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; RECEPTOR; UNCLASSIFIED DRUG; CALCIUM; GUANOSINE TRIPHOSPHATASE; HEPARIN; MFN2 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; RU 360; RUTHENIUM DERIVATIVE;

ADULT; AGED; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENDOPLASMIC RETICULUM; FEMALE; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR VOLUME; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; MIDDLE AGED; MITOCHONDRION; PATHOLOGY;

AGED; APOPTOSIS; CALCIUM; CARCINOMA, HEPATOCELLULAR; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GTP PHOSPHOHYDROLASES; HEP G2 CELLS; HEPARIN; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEOPLASM STAGING; REACTIVE OXYGEN SPECIES; RUTHENIUM COMPOUNDS;

EID: 84921311702     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.12.025     Document Type: Article

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