Pro-apoptotic and anti-proliferative effects of mitofusin-2 via Bax signaling in hepatocellular carcinoma cells

Medical Oncology

Volumn 29, Issue 1, 2012, Pages 70-76

  Wang, Weilin ^a,b   Lu, Jianju ^a,b   Zhu, Feng ^a,b   Wei, Jianfeng ^a,b   Jia, Changku ^a,b   Zhang, Yuanbiao ^a,b   Zhou, Lin ^a,b   Xie, Haiyang ^a,b   Zheng, Shusen ^a,b  

^a BEIJING HOSPITAL   (China)

^b First Affiliated Hospital   (China)

Author keywords

Apoptosis; Bax; Hepatocellular carcinoma; Mfn2; Mitochondria

Indexed keywords

CASPASE 3; CYTOCHROME C; GREEN FLUORESCENT PROTEIN; MITOFUSIN 2; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAX; SHORT HAIRPIN RNA;

ADENOVIRUS; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC REGULATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CELL SEPARATION; FLOW CYTOMETRY; GENES, TUMOR SUPPRESSOR; GTP PHOSPHOHYDROLASES; HUMANS; LIVER NEOPLASMS; MITOCHONDRIAL PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84860462092     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-010-9779-6     Document Type: Article

References (30)

1. Chen KH, et al. Dysregulation of HSG triggers vascular prolif-erative disorders. Nat Cell Biol. 2004;6:872-83.
2. Chen H, et al. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol. 2003;160:189-200. (Pubitemid 36254953)
3. Guo X, et al. Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway. Circ Res. 2007;101: 1113-22. (Pubitemid 350146437)
4. Karbowski M, et al. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol. 2002;159:931-8. (Pubitemid 36055748)
5. Santel A, Fuller MT. Control of mitochondrial morphology by a human mitofusin. J Cell Sci. 2001;114:867-74. (Pubitemid 32266258)
6. Rojo M, Legros F, Chateau D, Lombes A. Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J Cell Sci. 2002; 115:1663-74. (Pubitemid 34520596)
7. Zhang W, Della-Fera MA, Hartzell DL, Hausman D, Baile CA. Adipose tissue gene expression profiles in ob/ob mice treated with leptin. Life Sci. 2008;83:35-42.
8. Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene. 2003;22:8590-607. (Pubitemid 38028528)
9. Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol. 2001;3:E255-63.
10. Jeong SY, Seol DW. The role of mitochondria in apoptosis. BMB Rep. 2008;41:11-22.
11. Adams JM. Ways of dying: multiple pathways to apoptosis. Genes Dev. 2003;17:2481-95. (Pubitemid 37271417)
12. Green DR, Evan GI. A matter of life and death. Cancer Cell. 2002;1:19-30. (Pubitemid 41039172)
13. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74-108. (Pubitemid 40372904)
14. Fabregat I, Roncero C, Fernandez M. Survival and apoptosis: a dysregulated balance in liver cancer. Liver Int. 2007;27:155-62. (Pubitemid 46680718)
15. Guicciardi ME, Gores GJ. Apoptosis: a mechanism of acute and chronic liver injury. Gut. 2005;54:1024-33. (Pubitemid 40873921)
16. Ishihara N, Eura Y, Mihara K. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J Cell Sci. 2004;117:6535-46. (Pubitemid 40214575)
17. Mori N, et al. Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia. Blood. 1998;92:3405-9. (Pubitemid 28492351)
18. Smedley D, et al. Characterization of chromosome 1 abnormalities in malignant melanomas. Genes Chromosomes Cancer. 2000;28:121-5. (Pubitemid 30176770)
19. Bagchi A, Mills AA. The quest for the 1p36 tumor suppressor. Cancer Res. 2008;68:2551-6. (Pubitemid 351556249)
20. Wang W, et al. HSG provides antitumor efficacy on hepatocel-lular carcinoma both in vitro and in vivo. Oncol Rep. 2010;24: 183-8.
21. Fuke H, et al. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2007;363: 738-44. (Pubitemid 47513692)
22. Song G, et al. Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. Apoptosis. 2008;13: 693-701.
23. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science. 1985;228: 1440-3. (Pubitemid 15041322)
24. Brunelle JK, Letai A. Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci. 2009;122:437-41.
25. Crow MT, et al. The mitochondrial death pathway and cardiac myocyte apoptosis. Circ Res. 2004;95:957-70. (Pubitemid 39532326)
26. Boise LH, et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 1993;74: 597-608. (Pubitemid 23259741)
27. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993;74:609-19. (Pubitemid 23259742)
28. Wang K, et al. BID: a novel BH3 domain-only death agonist. Genes Dev. 1996;10:2859-69. (Pubitemid 26394246)
29. O'Connor L, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998;17:384-95. (Pubitemid 28045479)
30. Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci USA. 1997;94:3668-72.