Design and synthesis of pyrazole-oxindole conjugates targeting tubulin polymerization as new anticancer agents

European Journal of Medicinal Chemistry

Volumn 92, Issue , 2015, Pages 501-513

  Kamal, Ahmed ^a   Shaik, Anver Basha ^a   Jain, Nishant ^a   Kishor, Chandan ^a   Nagabhushana, Ananthamurthy ^b,c   Supriya, Bhukya ^a   Bharath Kumar, G ^a   Chourasiya, Sumit S ^a   Suresh, Yerramsetty ^a   Mishra, Rakesh K ^b   Addlagatta, Anthony ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

Author keywords

modeling; Pyrazoleeoxindole conjugates; Tubulin depolymerization; Zebrafish screening and molecular

Indexed keywords

ANTINEOPLASTIC AGENT; COLCHICINE; CYCLIN B1; OXINDOLE; PYRAZOLE; TUBULIN; INDOLE DERIVATIVE; PYRAZOLE DERIVATIVE; TUBULIN MODULATOR;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOMER; KNOEVENAGEL CONDENSATION; MICROTUBULE; MICROTUBULE ASSEMBLY; ZEBRA FISH; ANIMAL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; EMBRYOLOGY; HELA CELL LINE; MCF 7 CELL LINE; METABOLISM; MOLECULAR DOCKING; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; INDOLES; MCF-7 CELLS; MICROTUBULES; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; POLYMERIZATION; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS; TUMOR CELLS, CULTURED; ZEBRAFISH;

EID: 84921033774     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.077     Document Type: Article

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