Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 1, 2009, Pages 222-225

  Sidique, Shyama ^a   Ardecky, Robert ^a   Su, Ying ^a   Narisawa, Sonoko ^a   Brown, Brock ^a   Millán, José Luis ^a   Sergienko, Eduard ^a   Cosford, Nicholas D P ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Alkaline phosphatases; Competitive inhibitors; Hit to probe optimization; Pyrazoles

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; AMIDE; CID 646303; PYRAZOLE AMIDE DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CALCIFICATION; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; OSSIFICATION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

ALKALINE PHOSPHATASE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; PYRAZOLES;

EID: 57749084317     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.107     Document Type: Article

References (15)

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