Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1724-1734

  Zhong, Ye ^a   Xue, Mengzhu ^a   Zhao, Xue ^a   Yuan, Jun ^a   Liu, Xiaofeng ^a   Huang, Jin ^a   Zhao, Zhenjiang ^a   Li, Honglin ^a   Xu, Yufang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Kinase inhibitor; Molecular docking; RSK2

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 3 (FURAN 2 YLMETHYLENE) 5 METHOXYINDOLIN 2 ONE; 3 (FURAN 2 YLMETHYLENE) 5 NITROINDOLIN 2 ONE; 3 [(3 PHENYL 1H PYRAZOL 4 YL)METHYLENE]INDOLIN 2 ONE; 3 [[3 (2 NITROPHENYL) 1H PYRAZOL 4 YL]METHYLENE]INDOLIN 2 ONE; 3 [[5 (2 CHLOROPHENYL)FURAN 2 YL]METHYLENE]INDOLIN 2 ONE; 3 [[5 (3 BROMOPHENYL)FURAN 2 YL]METHYLENE] 5 CHLOROINDOLIN 2ONE; 3 [[5 (3 BROMOPHENYL)FURAN 2 YL]METHYLENE]INDOLIN 2 ONE; 5 (7 ETHYL 2 OXOINDOLIN 3 YLIDENE) 2 THIOXOTHIAZOLIDIN 4 ONE; 5 (7 METHYL 2 OXOINDOLIN 3 YLIDENE) 2 THIOXOTHIAZOLIDIN 4 ONE; 5 AMINO 3 (FURAN 2 YLMETHYLENE)INDOLIN 2 ONE; 5 BROMO 3 [[5 (2 CHLOROPHENYL)FURAN 2 YL]METHYLENE]INDOLIN 2 ONE; 5 BROMO 3 [[5 (3 BROMOPHENYL)FURAN 2 YL]METHYLENE]NDOLIN 2 ONE; 5 CHLORO 3 [[5 (2 CHLOROPHENYL)FURAN 2 YL]METHYLENE]INDOLIN 2 ONE; 5 FLUORO 3 [(3 PHENYL 1H PYRAZOL 4 YL)METHYLENE]INDOLIN 2 ONE; 6 BROMO 3 (FURAN 2 YLMETHYLENE)INDOLIN 2 ONE; 6 CHLORO 3 (FURAN 2 YLMETHYLENE)INDOLIN 2ONE; ANTINEOPLASTIC AGENT; PROTEIN INHIBITOR; S6 KINASE; SL 0101; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN MCF 7; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; INDOLES; MALE; MOLECULAR DOCKING SIMULATION; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875221928     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.047     Document Type: Article

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