Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 305-324

  Kumar, A Suresh ^a   Reddy, M Amarnath ^a   Jain, Nishant ^a   Kishor, Chandan ^a   Murthy, T Ramalinga ^a   Ramesh, Deepa ^a   Supriya, Bhukya ^a   Addlagatta, Anthony ^a   Kalivendi, Shasi V ^a   Sreedhar, B ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Antimicrotubule agents; Antiproliferative activity; Biaryl aryl ethylenes; Biaryl aryl stilbenes; Tubulin polymerization

Indexed keywords

COLCHICINE; CYCLIN B1; ETHYLENE DERIVATIVE; MOLECULAR SCAFFOLD; STILBENE DERIVATIVE; TUBULIN;

ANTIPROLIFERATIVE ACTIVITY; ANTITUBULIN ACTIVITY; ARTICLE; BINDING SITE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG ACTIVITY; DRUG BINDING SITE; DRUG DESIGN; DRUG SYNTHESIS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; PHARMACOPHORE; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ETHYLENES; HELA CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84872113095     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.008     Document Type: Article

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