Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress

Heart Rhythm

Volumn 12, Issue 2, 2015, Pages 440-448

  Belardinelli, Luiz ^a   Giles, Wayne R ^b   Rajamani, Sridharan ^a   Karagueuzian, Hrayr S ^c   Shryock, John C ^a  

^a GILEAD SCIENCES   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Afterpotential; Antiarrhythmicdrug; Dispersionofrepolarization; LongQTsyndrome; Ranolazine; Reentry; Repolarization reserve; Triggeredactivity

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; F 15845; FLECAINIDE; GS 458967; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; QUINIDINE; UNCLASSIFIED DRUG; SODIUM;

ACTION POTENTIAL DURATION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; HEART ATRIUM FIBRILLATION; HEART PROARRHYTHMIA; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; HUMAN; LONG QT SYNDROME; LONG QT SYNDROME 3; NONHUMAN; OXIDATIVE STRESS; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; SODIUM CALCIUM EXCHANGE; SODIUM CURRENT; TORSADE DES POINTES; ANIMAL; HEART MUSCLE CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; HUMANS; LONG QT SYNDROME; MYOCYTES, CARDIAC; OXIDATIVE STRESS; SODIUM;

EID: 84921032106     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.11.009     Document Type: Article

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