A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 4, 2009, Pages

  Song, Yejia ^a   Shryock, John C ^b   Belardinelli, Luiz ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b Gilead Sciences   (United States)

Author keywords

Action potential; Late sodium current; Spontaneous activity

Indexed keywords

ANEMONE TOXIN 2; HYDROGEN PEROXIDE; RANOLAZINE; SODIUM; TETRODOTOXIN; TOXIN; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; EXPERIMENTAL GUINEA PIG; HEART ATRIUM MUSCLE; HEART DEPOLARIZATION; HEART MUSCLE CELL; MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; SODIUM CURRENT;

ACETANILIDES; ACTION POTENTIALS; ANIMALS; ATRIAL FUNCTION; CNIDARIAN VENOMS; DIASTOLE; FEMALE; GUINEA PIGS; HEART ATRIA; HYDROGEN PEROXIDE; KINETICS; MALE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PIPERAZINES; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TACHYCARDIA, SUPRAVENTRICULAR; TETRODOTOXIN;

EID: 70349623327     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00444.2009     Document Type: Article

References (51)

1. Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110: 904-910, 2004. (Pubitemid 39136212)
2. + current contribution to the diastolic depolarization in newborn rabbit SA node cells. Am J Physiol Heart Circ Physiol 279: H2303-H2309, 2000.
3. Benito B, Brugada R, Perich RM, Lizotte E, Cinca J, Mont L, Berruezo A, Tolosana JM, Freixa X, Brugada P, Brugada J. A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation. Heart Rhythm 5: 1434-1440, 2008.
4. Burashnikov A, Di Diego J, Zygmunt AC, Belarinelli L, Antzelevitch C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation. Difference in sodium channel inactivation between atrial and ventricles and the role of ranolazine. Circulation 116: 1449-1457, 2007. (Pubitemid 47480635)
5. Carmeliet E. Slow inactivation of the sodium current in rabbit cardiac Purkinje fibers. Pflügers Arch 408: 18-26, 1987.
6. Darbar D, Kannankeril PJ, Donahue BS, Kucera G, Stubblefield T, Haines JL, George AL, Roden DM. Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation 117: 1927-1935, 2008.
7. Escande D, Coraboeuf E, Planché C, Lacour-Gayet F. Effects of potassium conductance inhibitors on spontaneous diastolic depolarization and abnormal automaticity in human atrial fibers. Basic Res Cardiol 81: 244-257, 1986. (Pubitemid 16059186)
8. Na and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. J Cardiovasc Electrophysiol 17, Suppl 1: S71-S78, 2006.
9. Feng J, Yue L, Wang Z, Nattel S. Ionic mechanisms of regional action potential heterogeneity in the canine right atrium. Circ Res 83: 541-551, 1998. (Pubitemid 28411056)
10. Giles WR, Imaizumi Y. Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol 405: 123-145, 1988. (Pubitemid 18250333)
11. Hammarström AK, Gage PW. Hypoxia and persistent sodium current. Eur Biophys J 31: 323-330, 2002.
12. Harris DR, Green WL, Craelius W. Acute thyroid hormone promotes slow inactivation of sodium current in neonatal cardiac myocytes. Biochim Biophys Acta 1045: 175-181, 1991.
13. Hogan PM, Davis LD. Evidence for specialized fibers in the canine right atrium. Circ Res 23: 387-396, 1968.
14. 2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol 524: 415-422, 2000.
15. Isenberg G, Ravens U. The effects of the anemonia sulcata toxin (ATX-II) on membrane currents of isolated mammalian myocytes. J Physiol 357: 127-149, 1984. (Pubitemid 15175336)
16. Johnson JN, Tester DJ, Perry J, Salisbury BA, Reed CR, Ackerman MJ. Prevalence of early-onset atrial fibrillation in congenital long QT syndrome. Heart Rhythm 5: 704-709, 2008.
17. Ju YK, Saint DA, Gage PW. Tetrodotoxin-sensitive inactivation-resistant sodium channels in pacemaker cells influence heart rate. Pflügers Arch 431: 868-875, 1996.
18. + channels. FASEB J 3: 1963-1967, 1989.
19. Li GR, Lau CP, Shrier A. Heterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts. J Mol Cell Cardiol 34: 1185-1194, 2002. (Pubitemid 35205164)
20. Li D, Zhang L, Kneller J, Nattel S. Potential ionic mechanism for repolarization differences between canine right and left atrium. Circ Res 88: 1168-1175, 2001. (Pubitemid 34132517)
21. Lin WS, Tai CT, Hsieh MH, Tsai CF, Lin YK, Tsao HM, Huang JL, Yu WC, Yang SP, Ding YA, Chang MS, Chen SA. Catheter ablation of paroxysmal atrial fibrillation initiated by non-pulmonary vein ectopy. Circulation 107: 3176-3183, 2003. (Pubitemid 36793088)
22. Liu YM, DeFelice LJ, Mazzanti M. Na channels that remain open throughout the cardiac action potential plateau. Biophys J 63: 654-662, 1992.
23. Ma J, Luo A, Zhang P. Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes. Acta Pharmacol Sin 26: 828-834, 2005. (Pubitemid 40978764)
24. Maltsev VA, Sabbah HN, Higgins RSD, Silverman N, Lesch M, Undrovinas AI. Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes. Circulation 98: 2545-2552, 1998. (Pubitemid 29001193)
25. Maltsev VA, Silverman N, Sabbah HN, Undrovinas AI. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail 9: 219-227, 2007. (Pubitemid 46330143)
26. + current in human ventricular cardiomyocytes. Cardiovasc Res 69: 116-127, 2006.
27. Mangoni ME, Nargeot J. Genesis and regulation of the heart automaticity. Physiol Rev 88: 919-982, 2008.
28. Mary-Rabine L, Hordof AJ, Danilo P Jr, Malm JR, Rosen MR. Mechanisms for impulse initiation in isolated human atrial fibers. Circ Res 47: 267-277, 1980. (Pubitemid 10056055)
29. Nattel S. Atrial electrophysiology and mechanisms of atrial fibrillation. J Cardiovasc Pharmacol Therapeut 8, Suppl 1: S5-S11, 2003.
30. Rota M, Vassalle M. Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range. J Physiol 548: 147-165, 2003. (Pubitemid 36410805)
31. Rubenstein DS, Fox LM, McNulty JA, Lipsius SL. Electrophysiology and ultrastructure of Eustachian ridge from cat right atrium: a comparison with SA node. J Mol Cell Cardiol 19: 965-976, 1987.
32. Rubenstein DS, Lipsius SL. Mechanisms of automaticity in subsidiary pacemakers from cat right atrium. Circ Res 64: 648-657, 1989.
33. Saint DA, Ju YK, Gage PW. A persistent sodium current in rat ventricular myocytes. J Phsiol 453: 219-231, 1992.
34. Sakakibara Y, Wasserstrom JA, Furukawa T, Jia H, Arentzen CE, Hartz RS, Singer DH. Characterization of the sodium current in single human atrial myocytes. Circ Res 71: 535-546, 1992.
35. Sakmann BF, Spindler AJ, Bryant SM, Linz KW, Noble D. Distribution of a persistent sodium current across the ventricular wall in guinea pigs. Circ Res 87: 910-914, 2000. (Pubitemid 30943829)
36. Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S. Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects. Br J Pharmacol 142: 1300-1308, 2004. (Pubitemid 39185852)
37. Slezak J, Tribulova N, Pristacova J, Uhrik B, Thomas T, Khaper N, Kaul N, Singal PK. Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis. Am J Pathol 147: 772-781, 1995.
38. Song Y, Shryock JC, Belardinelli L. An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. Am J Physiol Heart Circ Physiol 294: H2031-H2039, 2008.
39. Song Y, Shryock JC, Wagner S, Maier LS, Belardinelli L. Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J Pharmacol Exp Ther 318: 214-222, 2006. (Pubitemid 43920758)
40. Na in guinea pig ventricular myocytes. J Cardiovasc Pharmacol 44: 192-199, 2004.
41. Tamargo JT, Caballero R, Delpón E. Pharmacological approaches in the treatment of atrial fibrillation. Curr Med Chem 11: 13-28, 2004. (Pubitemid 38081732)
42. Trautwein W, Kassebaum DG, Nelson RM, Hecht HH. Electrophysiological study of human heart muscle. Circ Res 10: 306-312, 1962.
43. Undrovinas AI, Belardinelli L, Undrovinas NA, Sabbah HN. Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol 17, Suppl 1: S169-S177, 2006.
44. Valdivia CR, Chu WW, Pu J, Foell JD, Haworth RA, Wolff MR, Kamp TJ, Makielski JC. Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J Mol Cell Cardiol 38: 475-483, 2005. (Pubitemid 40331938)
45. Wang W, Ma J, Zhang P, Luo A. Redox reaction modulates transient and persistent sodium current during hypoxia in guinea pig ventricular myocytes. Pflügers Arch 454: 461-475, 2007.
46. Wang Z, Yue L, White M, Pelletier G, Nattel S. Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. Circulation 98: 2422-2428, 1998. (Pubitemid 28549786)
47. + currents in rat ventricular myocytes. Prog Biophys Mol Biol 90: 249-269, 2006.
48. Ward CA, Giles WR. Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes. J Physiol 500: 631-642, 1997. (Pubitemid 27207825)
49. Wit AL, Cranefield PF. Triggered and automatic activity in the canine coronary sinus. Circ Res 41: 434-445, 1977.
50. Wu J, Vereecke J, Carmeliet E, Lipsius SL. Ionic currents activated during hyperpolarization of single right atrial myocytes from cat heart. Circ Res 68: 1059-1069, 1991.
51. Zellerhoff S, Pistulli R, Mönnig G, Hinterseer M, Beckmann BM, Köbe J, Steinbeck G, Kääb S, Haverkamp W, Fabritz L, Gradaus R, Breithardt G, Schulze-Bahr E, Böcker D, Kirchhof P. Atrial arrhythmias in long-QT syndrome under daily life conditions: a nested case control study. J Cardiovasc Electrophysiol 20: 401-407, 2009.