Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner

Current Therapeutic Research - Clinical and Experimental

Volumn 76, Issue , 2014, Pages 70-75

  Sag, Can M ^a,c   Mallwitz, Anika ^b   Wagner, Stefan ^a   Hartmann, Nico ^b   Schotola, Hanna ^b   Fischer, Thomas H ^b   Ungeheuer, Nele ^b   Herting, Jonas ^b   Shah, Ajay M ^c   Maier, Lars S ^a   Sossalla, Samuel ^b   Unsöld, Bernhard ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Arrhythmogenesis; CaMKII; Heart failure; Late INa; SR Ca leak

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; RANOLAZINE; CALCIUM; COELENTERATE VENOM; SODIUM; TOXIN II (ANEMONIA SULCATA);

ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; AUTOPHOSPHORYLATION; CALCIUM TRANSPORT; CONTROLLED STUDY; DIASTOLE; DIASTOLIC BLOOD PRESSURE; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART FAILURE; HEART PAPILLARY MUSCLE; HEART PROARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MOUSE; MUSCLE CELL; MUSCLE TWITCH; NONHUMAN; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; SODIUM CURRENT; WILD TYPE; ACTION POTENTIAL; ANIMAL; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; HEART ARRHYTHMIA; HEART MUSCLE CELL; METABOLISM; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; CNIDARIAN VENOMS; MICE, TRANSGENIC; MYOCYTES, CARDIAC; SARCOPLASMIC RETICULUM; SODIUM;

EID: 84964314327     PISSN: 0011393X     EISSN: 18790313     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.08.016     Document Type: Article

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