Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes

Journal of Molecular and Cellular Cardiology

Volumn 76, Issue , 2014, Pages 247-256

  Viatchenko Karpinski, Serge ^a   Kornyeyev, Dmytro ^a   El Bizri, Nesrine ^a   Budas, Grant ^a   Fan, Peidong ^a   Jiang, Zhan ^a   Yang, Jin ^b,c   Anderson, Mark E ^d,f   Shryock, John C ^a   Chang, Ching Pin ^b,c   Belardinelli, Luiz ^a   Yao, Lina ^a,e  

^a Department of Biology Gilead Sciences ^*  (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e GILEAD SCIENCES   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATX II; CaMKII; Late sodium current; Mitochondria; ROS; RyRs

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; REACTIVE OXYGEN METABOLITE; SODIUM ION; SODIUM;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CONTROLLED STUDY; CYTOSOL; DIASTOLE; ELECTROLYTE DISTURBANCE; ENZYME METABOLISM; HEART MUSCLE CELL; HEART VENTRICLE; MITOCHONDRION; NONHUMAN; SARCOPLASMIC RETICULUM; SODIUM CELL LEVEL; SODIUM CURRENT; SODIUM OVERLOAD; ACTION POTENTIAL; ANIMAL; CALCIUM SIGNALING; CYTOLOGY; ENZYMOLOGY; FEMALE; INTRACELLULAR SPACE; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RABBIT;

ACTION POTENTIALS; ANIMALS; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; FEMALE; HEART VENTRICLES; INTRACELLULAR SPACE; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; OXIDATIVE STRESS; RABBITS; REACTIVE OXYGEN SPECIES; SODIUM;

EID: 84907806240     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.09.009     Document Type: Article

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