Highly concentrated monoclonal antibody solutions: Direct analysis of physical structure and thermal stability

Journal of Pharmaceutical Sciences

Volumn 96, Issue 3, 2007, Pages 532-546

  Harn, N ^a   Allan, C ^b   Oliver, C ^b   Middaugh, C R ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b Medlmmune   (United States)

Author keywords

CD; DSC; Formulation; Front surface fluorescence; FTIR; High concentration; Monoclonal antibody; Thermal stability; UV

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY;

ARTICLE; CIRCULAR DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DETERMINATION; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; EMPIRICISM; FLUORESCENCE ANALYSIS; GEOMETRY; INFRARED SPECTROSCOPY; INTERMETHOD COMPARISON; MELTING POINT; OPTICAL DENSITY; PROTEIN TERTIARY STRUCTURE; TEMPERATURE MEASUREMENT; THERMOSTABILITY; ULTRAVIOLET SPECTROSCOPY;

EID: 33947544337     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20753     Document Type: Article

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