Impact of short range hydrophobic interactions and long range electrostatic forces on the aggregation kinetics of a monoclonal antibody and a dual-variable domain immunoglobulin at low and high concentrations

International Journal of Pharmaceutics

Volumn 421, Issue 1, 2011, Pages 82-93

  Kumar, Vineet ^a   Dixit, Nitin ^b   Zhou, Liqiang ^a   Fraunhofer, Wolfgang ^c  

^a ABBOTT LABORATORIES   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c Pharmaceutics Drug Product Development   (United States)

Author keywords

Aggregation; High concentration protein formulations; Hydrophobic interactions; Low ionic formulations; Second virial coefficient

Indexed keywords

DUAL VARIABLE DOMAIN IMMUNOGLOBULIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; DIFFERENTIAL SCANNING CALORIMETRY; FEMALE; HYDROPHOBICITY; IONIC STRENGTH; LIGHT SCATTERING; MICROCALORIMETRY; MOLECULAR CLONING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; STATIC ELECTRICITY; THERMOSTABILITY;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; DRUG STABILITY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN G; KINETICS; OSMOLAR CONCENTRATION; PROTEIN INTERACTION MAPPING; STATIC ELECTRICITY;

EID: 81155122975     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.09.017     Document Type: Article

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