CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 2, 2015, Pages 524-529

  Wang, Chun Jing ^a   Heuts, Frank ^a   Ovcinnikovs, Vitalijs ^a   Wardzinski, Lukasz ^a   Bowers, Chantelle ^a   Schmidt, Emily M ^b   Kogimtzis, Alexandros ^a   Kenefeck, Rupert ^a   Sansom, David M ^a   Walker, Lucy S K ^a   Weiss, Arthur ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmunity; CD28; Costimulation; CTLA 4; TCell

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 17; INTERLEUKIN 21; KI 67 ANTIGEN; L SELECTIN; MESSENGER RNA; MICRORNA; PROTEIN BCL 6; AUTOANTIBODY; CD86 PROTEIN, MOUSE; CTLA4 PROTEIN, MOUSE; LIGAND; MIRN17-92 MICRORNA, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FOLLICULAR HELPER T CELL; HELPER CELL; HETEROZYGOSITY; HUMORAL IMMUNITY; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION; ADAPTIVE IMMUNITY; ANIMAL; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; DEFICIENCY; GENETICS; GERMINAL CENTER; HETEROZYGOTE; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM;

MUS;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, CD86; AUTOANTIBODIES; CELL DIFFERENTIATION; CTLA-4 ANTIGEN; GERMINAL CENTER; HETEROZYGOTE; LIGANDS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICRORNAS; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84920998783     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414576112     Document Type: Article

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