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Volumn 8, Issue JAN, 2015, Pages

The role of ion channels in the hypoxia-induced aggressiveness of glioblastoma

Author keywords

Aggressiveness; Cancer; Glioblastoma multiforme (GBM); Hypoxia; Ion channels

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL T TYPE; CARMUSTINE; CONNEXIN 43; DOXORUBICIN; HEME OXYGENASE 2; ION CHANNEL; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; POTASSIUM CHANNEL; PROTEIN BAX; PROTEIN BAX 2; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; STROMAL INTERACTION MOLECULE 1; TEMOZOLOMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

EID: 84920996823     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00467     Document Type: Article
Times cited : (19)

References (90)
  • 1
    • 84863042917 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells
    • Ahn, Y. T., Kim, Y. M., Adams, E., Lyu, S. C., Alvira, C. M., and andCornfield, D. N. (2012). Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung. Cell. Mol. Physiol. 302, L352-L359. doi: 10.1152/ajplung.00302.2011
    • (2012) Am. J. Physiol. Lung. Cell. Mol. Physiol , vol.302 , pp. L352-L359
    • Ahn, Y.T.1    Kim, Y.M.2    Adams, E.3    Lyu, S.C.4    Alvira, C.M.5    andCornfield, D.N.6
  • 2
    • 84903640490 scopus 로고    scopus 로고
    • Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system
    • Akita, T., and Okada, Y. (2014). Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system. Neuroscience 275, 211-231. doi: 10.1016/j.neuroscience.2014.06.015
    • (2014) Neuroscience , vol.275 , pp. 211-231
    • Akita, T.1    Okada, Y.2
  • 3
    • 84876881518 scopus 로고    scopus 로고
    • Enhancing radiation therapy for patients with glioblastoma
    • Alexander, B. M., Ligon, K. L., and Wen, P. Y. (2013). Enhancing radiation therapy for patients with glioblastoma.Expert Rev. Anticancer Ther. 13, 569-581. doi: 10.1586/era.13.44
    • (2013) Expert Rev. Anticancer Ther , vol.13 , pp. 569-581
    • Alexander, B.M.1    Ligon, K.L.2    Wen, P.Y.3
  • 4
    • 34447316691 scopus 로고    scopus 로고
    • Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation
    • Amantini, C., Mosca, M., Nabissi, M., Lucciarini, R., Caprodossi, S., Arcella, A., et al. (2007). Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. J. Neurochem. 102, 977-990. doi: 10.1111/j.1471-4159.2007.04582.x
    • (2007) J. Neurochem , vol.102 , pp. 977-990
    • Amantini, C.1    Mosca, M.2    Nabissi, M.3    Lucciarini, R.4    Caprodossi, S.5    Arcella, A.6
  • 5
    • 65649115060 scopus 로고    scopus 로고
    • Hypoxia helps glioma to fight therapy
    • Amberger-Murphy, V. (2009). Hypoxia helps glioma to fight therapy. Curr. Cancer Drug Targets 9, 381-390. doi: 10.2174/156800909788166637
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 381-390
    • Amberger-Murphy, V.1
  • 6
    • 0034235510 scopus 로고    scopus 로고
    • Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration
    • Bordey, A., Sontheimer, H., and Trouslard, J. (2000). Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration. J. Membr. Biol. 176, 31-40. doi: 10.1007/s002320001073
    • (2000) J. Membr. Biol , vol.176 , pp. 31-40
    • Bordey, A.1    Sontheimer, H.2    Trouslard, J.3
  • 7
    • 2342588221 scopus 로고    scopus 로고
    • Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis and accelerated growth in glioblastoma
    • Brat, D. J., and Van Meir, E. G. (2004). Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis and accelerated growth in glioblastoma. Lab. Invest. 84, 397-405. doi: 10.1038/labinvest.3700070
    • (2004) Lab. Invest , vol.84 , pp. 397-405
    • Brat, D.J.1    Van Meir, E.G.2
  • 8
    • 33644870946 scopus 로고    scopus 로고
    • The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia
    • Burton, T. R., Hensonm, E. S., Baijalm, P., Eisenstatm, D. D., and Gibson, S. B. (2006). The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: implications for glioblastoma multiforme tumor cell survival under hypoxia. Int. J. Cancer. 118, 1660-1669. doi: 10.1002/ijc.21547
    • (2006) Int. J. Cancer , vol.118 , pp. 1660-1669
    • Burton, T.R.1    Hensonm, E.S.2    Baijalm, P.3    Eisenstatm, D.D.4    Gibson, S.B.5
  • 10
    • 36049022753 scopus 로고    scopus 로고
    • Fast exocytosis mediated by T- and L-type channels in chromaffin cells: Distinct voltage-dependence but similar Ca2+ -dependence
    • Carabelli, V., Marcantoni, A., Comunanza, V., and Carbone, E. (2007). Fast exocytosis mediated by T- and L-type channels in chromaffin cells: distinct voltage-dependence but similar Ca2+ -dependence. Eur. Biophys. J. 36, 753-762. doi: 10.1007/s00249-007-0138-2
    • (2007) Eur. Biophys. J , vol.36 , pp. 753-762
    • Carabelli, V.1    Marcantoni, A.2    Comunanza, V.3    Carbone, E.4
  • 11
    • 79955049771 scopus 로고    scopus 로고
    • Serum-activated K and Cl currents underlay U87-MG glioblastoma cell migration
    • Catacuzzeno, L., Aiello, F., Fioretti, B., Sforna, L., Castigli, E., Ruggieri, P., et al. (2011). Serum-activated K and Cl currents underlay U87-MG glioblastoma cell migration. J. Cell. Physiol. 226, 1926-1933. doi: 10.1002/jcp.22523
    • (2011) J. Cell. Physiol , vol.226 , pp. 1926-1933
    • Catacuzzeno, L.1    Aiello, F.2    Fioretti, B.3    Sforna, L.4    Castigli, E.5    Ruggieri, P.6
  • 12
    • 84867732950 scopus 로고    scopus 로고
    • Expression and role of the intermediate-conductance calcium-activated potassium channel KCa3.1 in glioblastoma
    • Catacuzzeno, L., Fioretti, B., and Franciolini, F. (2012). Expression and role of the intermediate-conductance calcium-activated potassium channel KCa3.1 in glioblastoma. J. Signal Transduct. 2012:421564. doi: 10.1155/2012/421564
    • (2012) J. Signal Transduct , vol.2012
    • Catacuzzeno, L.1    Fioretti, B.2    Franciolini, F.3
  • 13
    • 84891868183 scopus 로고    scopus 로고
    • Identification of key signaling molecules involved in the activation of the swelling-activated chloride current in human glioblastoma cells
    • Catacuzzeno, L., Michelucci, A., Sforna, L., Aiello, F., Sciaccaluga, M., Fioretti, B., et al. (2014). Identification of key signaling molecules involved in the activation of the swelling-activated chloride current in human glioblastoma cells. J. Membr. Biol. 247, 45-55. doi: 10.1007/s00232-013-9609-9
    • (2014) J. Membr. Biol , vol.247 , pp. 45-55
    • Catacuzzeno, L.1    Michelucci, A.2    Sforna, L.3    Aiello, F.4    Sciaccaluga, M.5    Fioretti, B.6
  • 14
    • 75149130024 scopus 로고    scopus 로고
    • Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness
    • Chigurupati, S., Venkataraman, R., Barrera, D., Naganathan, A., Madan, M., Paul, L., et al. (2010). Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res. 70, 418-427. doi: 10.1158/0008-5472.can-09-2654
    • (2010) Cancer Res , vol.70 , pp. 418-427
    • Chigurupati, S.1    Venkataraman, R.2    Barrera, D.3    Naganathan, A.4    Madan, M.5    Paul, L.6
  • 15
    • 34948892058 scopus 로고    scopus 로고
    • Diffuse glioma growth: A guerilla war
    • Claes, A., Idema, A. J., and Wesseling, P. (2007). Diffuse glioma growth: a guerilla war. Acta Neuropathol. 114, 443-458. doi: 10.1007/s00401-007-0293-7
    • (2007) Acta Neuropathol , vol.114 , pp. 443-458
    • Claes, A.1    Idema, A.J.2    Wesseling, P.3
  • 16
    • 0037096732 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
    • Comerford, K. M., Wallace, T. J., Karhausen, J., Louis, N. A., Montalto, M. C., and Colgan, S. P. (2002). Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res. 62, 3387-3394.
    • (2002) Cancer Res , vol.62 , pp. 3387-3394
    • Comerford, K.M.1    Wallace, T.J.2    Karhausen, J.3    Louis, N.A.4    Montalto, M.C.5    Colgan, S.P.6
  • 17
    • 0348049844 scopus 로고    scopus 로고
    • Irradiation differentially affects substratum-dependent survival, adhesion and invasion of glioblastoma cell lines
    • Cordes, N., Hansmeier, B., Beinke, C., Meineke, V., and van Beuningen, D. (2003). Irradiation differentially affects substratum-dependent survival, adhesion and invasion of glioblastoma cell lines. Br. J. Cancer. 89, 2122-2132.
    • (2003) Br. J. Cancer , vol.89 , pp. 2122-2132
    • Cordes, N.1    Hansmeier, B.2    Beinke, C.3    Meineke, V.4    van Beuningen, D.5
  • 18
    • 80052239688 scopus 로고    scopus 로고
    • Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration
    • Cuddapah, V. A., and Sontheimer, H. (2011). Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration. Am. J. Physiol. Cell Physiol. 301, C541-C549. doi: 10.1152/ajpcell.00102.2011
    • (2011) Am. J. Physiol. Cell Physiol , vol.301 , pp. C541-C549
    • Cuddapah, V.A.1    Sontheimer, H.2
  • 19
    • 0038492596 scopus 로고    scopus 로고
    • Induction of T-type calcium channel gene expression by chronic hypoxia
    • Del Toro, R., Levitsky, K. L., López-Barneo, J., and Chiara, M. D. (2003). Induction of T-type calcium channel gene expression by chronic hypoxia. J. Biol. Chem. 278, 22316-22324. doi: 10.1074/jbc.m212576200
    • (2003) J. Biol. Chem , vol.278 , pp. 22316-22324
    • Del Toro, R.1    Levitsky, K.L.2    López-Barneo, J.3    Chiara, M.D.4
  • 20
    • 0037423212 scopus 로고    scopus 로고
    • Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2
    • Deshane, J., Garner, C. C., and Sontheimer, H. (2003). Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. J. Biol. Chem. 278, 4135-4144. doi: 10.1074/jbc.m205662200
    • (2003) J. Biol. Chem , vol.278 , pp. 4135-4144
    • Deshane, J.1    Garner, C.C.2    Sontheimer, H.3
  • 21
    • 84892502745 scopus 로고    scopus 로고
    • Injury-triggered Akt phosphorylation of Cx43: A ZO-1-driven molecular switch that regulates gap junction size
    • Dunn, C. A., and Lampe, P. D. (2014). Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size. J. Cell Sci. 127, 455-464. doi: 10.1242/jcs.142497
    • (2014) J. Cell Sci , vol.127 , pp. 455-464
    • Dunn, C.A.1    Lampe, P.D.2
  • 22
    • 40549114267 scopus 로고    scopus 로고
    • Cytoplasmic condensation is both necessary and sufficient to induce apoptotic cell death
    • Ernest, N. J., Habela, C. W., and Sontheimer, H. (2008). Cytoplasmic condensation is both necessary and sufficient to induce apoptotic cell death. J. Cell Sci. 121, 290-297. doi: 10.1242/jcs.017343
    • (2008) J. Cell Sci , vol.121 , pp. 290-297
    • Ernest, N.J.1    Habela, C.W.2    Sontheimer, H.3
  • 23
    • 22244476080 scopus 로고    scopus 로고
    • Relative contribution of chloride channels and transporters to regulatory volume decrease in human glioma cells
    • Ernest, N. J., Weaver, A. K., Van Duyn, L. B., and Sontheimer, H. W. (2005). Relative contribution of chloride channels and transporters to regulatory volume decrease in human glioma cells. Am. J. Physiol. Cell Physiol. 288, C1451-C1460. doi: 10.1152/ajpcell.00503.2004
    • (2005) Am. J. Physiol. Cell Physiol , vol.288 , pp. C1451-C1460
    • Ernest, N.J.1    Weaver, A.K.2    Van Duyn, L.B.3    Sontheimer, H.W.4
  • 24
    • 84880182849 scopus 로고    scopus 로고
    • CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α
    • Esencay, M., Sarfraz, Y., and Zagzag, D. (2013). CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α. BMC Cancer 13:347. doi: 10.1186/1471-2407-13-347
    • (2013) BMC Cancer , vol.13 , pp. 347
    • Esencay, M.1    Sarfraz, Y.2    Zagzag, D.3
  • 25
    • 0035254554 scopus 로고    scopus 로고
    • Propagation of intercellular calcium waves in C6 glioma cells transfected with connexins 43 or 32
    • Fry, T., Evans, J. H., and Sanderson, M. J. (2001). Propagation of intercellular calcium waves in C6 glioma cells transfected with connexins 43 or 32. Microsc. Res. Tech. 52, 289-300. doi: 10.1002/1097-0029(20010201)52:3<289::aid-jemt1014>3.0.co;2-0
    • (2001) Microsc. Res. Tech , vol.52 , pp. 289-300
    • Fry, T.1    Evans, J.H.2    Sanderson, M.J.3
  • 26
    • 84888421545 scopus 로고    scopus 로고
    • Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics
    • Fujimura, A., Michiue, H., Cheng, Y., Uneda, A., Tani, Y., Nishiki, T., et al. (2013). Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics. Neoplasia 15, 1272-1281. doi: 10.1593/neo.131440
    • (2013) Neoplasia , vol.15 , pp. 1272-1281
    • Fujimura, A.1    Michiue, H.2    Cheng, Y.3    Uneda, A.4    Tani, Y.5    Nishiki, T.6
  • 27
    • 84890434993 scopus 로고    scopus 로고
    • Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway
    • Gielen, P. R., Aftab, Q., Ma, N., Chen, V. C., Hong, X., Lozinsky, S., et al. (2013). Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway. Neuropharmacology 75, 539-548. doi: 10.1016/j.neuropharm.2013.05.002
    • (2013) Neuropharmacology , vol.75 , pp. 539-548
    • Gielen, P.R.1    Aftab, Q.2    Ma, N.3    Chen, V.C.4    Hong, X.5    Lozinsky, S.6
  • 28
    • 0033224243 scopus 로고    scopus 로고
    • Selective transfer of endogenous metabolites through gap junctions composed of different connexins
    • Goldberg, G. S., Lampe, P. D., and Nicholson, B. J. (1999). Selective transfer of endogenous metabolites through gap junctions composed of different connexins. Nat. Cell Biol. 1, 457-459.
    • (1999) Nat. Cell Biol , vol.1 , pp. 457-459
    • Goldberg, G.S.1    Lampe, P.D.2    Nicholson, B.J.3
  • 29
    • 0037382614 scopus 로고    scopus 로고
    • Beyond the gap: Functions of unpaired connexon channels
    • Goodenough, D. A., and Paul, D. L. (2003). Beyond the gap: functions of unpaired connexon channels. Nat. Rev. Mol. Cell Biol. 4, 285-294. doi: 10.1038/nrm1072
    • (2003) Nat. Rev. Mol. Cell Biol , vol.4 , pp. 285-294
    • Goodenough, D.A.1    Paul, D.L.2
  • 30
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., and Scott, O. C. (1953). The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br. J. Radiol. 26, 638-648. doi: 10.1259/0007-1285-26-312-638
    • (1953) Br. J. Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.5
  • 31
    • 34249113091 scopus 로고    scopus 로고
    • Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells
    • Grayson, W. L., Zhao, F., Bunnell, B., and Ma, T. (2007). Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem. Biophys. Res. Commun. 358, 948-953. doi: 10.1016/j.bbrc.2007.05.054
    • (2007) Biochem. Biophys. Res. Commun , vol.358 , pp. 948-953
    • Grayson, W.L.1    Zhao, F.2    Bunnell, B.3    Ma, T.4
  • 32
    • 84893758920 scopus 로고    scopus 로고
    • Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma
    • Gu, X. Q., Pamenter, M. E., Siemen, D., Sun, X., and Haddad, G. G. (2014). Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma. Glia 62, 504-513. doi: 10.1002/glia.22620
    • (2014) Glia , vol.62 , pp. 504-513
    • Gu, X.Q.1    Pamenter, M.E.2    Siemen, D.3    Sun, X.4    Haddad, G.G.5
  • 34
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulatory factor in tumour growth
    • Harris, A. L. (2002). Hypoxia-a key regulatory factor in tumour growth. Nat. Rev. Cancer. 2, 38-47. doi: 10.1038/nrc704
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 35
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • Holland, E. C. (2001). Gliomagenesis: genetic alterations and mouse models. Nat. Rev. Genet. 2, 120-129
    • (2001) Nat. Rev. Genet , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 36
    • 84871775342 scopus 로고    scopus 로고
    • Silencing of STIM1 attenuates hypoxia-induced PASMCs proliferation via inhibition of the SOC/Ca2+/NFAT pathway
    • Hou, X., Chen, J., Luo, Y., Liu, F., Xu, G., and Gao, Y. (2013). Silencing of STIM1 attenuates hypoxia-induced PASMCs proliferation via inhibition of the SOC/Ca2+/NFAT pathway. Respir. Res. 14:2. doi: 10.1186/1465-9921-14-2
    • (2013) Respir. Res , vol.14 , pp. 2
    • Hou, X.1    Chen, J.2    Luo, Y.3    Liu, F.4    Xu, G.5    Gao, Y.6
  • 37
    • 78649396776 scopus 로고    scopus 로고
    • Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity
    • Hsieh, C. H., Lee, C. H., Liang, J. A., Yu, C. Y., and Shyu, W. C. (2010). Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity. Oncol. Rep. 24, 1629-1636. doi: 10.3892/or_00001027
    • (2010) Oncol. Rep , vol.24 , pp. 1629-1636
    • Hsieh, C.H.1    Lee, C.H.2    Liang, J.A.3    Yu, C.Y.4    Shyu, W.C.5
  • 38
    • 84864404681 scopus 로고    scopus 로고
    • NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme
    • Hsieh, C. H., Wu, C. P., Lee, H. T., Liang, J. A., Yu, C. Y., and Lin, Y. J. (2012). NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme. Free Radic. Biol. Med. 53, 649-658. doi: 10.1016/j.freeradbiomed.2012.06.009
    • (2012) Free Radic. Biol. Med , vol.53 , pp. 649-658
    • Hsieh, C.H.1    Wu, C.P.2    Lee, H.T.3    Liang, J.A.4    Yu, C.Y.5    Lin, Y.J.6
  • 39
    • 0032533831 scopus 로고    scopus 로고
    • Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43)
    • Huang, R. P., Fan, Y., Hossain, M. Z., Peng, A., Zeng, Z. L., and Boynton, A. L. (1998). Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43). Cancer Res. 58, 5089-5096.
    • (1998) Cancer Res , vol.58 , pp. 5089-5096
    • Huang, R.P.1    Fan, Y.2    Hossain, M.Z.3    Peng, A.4    Zeng, Z.L.5    Boynton, A.L.6
  • 40
    • 65249131228 scopus 로고    scopus 로고
    • Brain tumor hypoxia: Tumorigenesis, angiogenesis, imaging, pseudoprogression and as a therapeutic target
    • Jensen, R. L. (2009). Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression and as a therapeutic target. J. Neurooncol. 92, 317-335. doi: 10.1007/s11060-009-9827-2
    • (2009) J. Neurooncol , vol.92 , pp. 317-335
    • Jensen, R.L.1
  • 41
    • 0037332585 scopus 로고    scopus 로고
    • Large conductance Ca2+-activated K+ channels sense acute changes in oxygen tension in alveolar epithelial cells
    • Jovanović, S., Crawford, R. M., Ranki, H. J., and Jovanović, A. (2003). Large conductance Ca2+-activated K+ channels sense acute changes in oxygen tension in alveolar epithelial cells. Am. J. Respir. Cell Mol. Biol. 28, 363-372. doi: 10.1165/rcmb.2002-0101oc
    • (2003) Am. J. Respir. Cell Mol. Biol , vol.28 , pp. 363-372
    • Jovanović, S.1    Crawford, R.M.2    Ranki, H.J.3    Jovanović, A.4
  • 42
    • 48949115123 scopus 로고    scopus 로고
    • Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells
    • Kang, M. K., and Kang, S. K. (2008). Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells. Biochem. Biophys. Res. Commun. 373, 539-544. doi: 10.1016/j.bbrc.2008.06.070
    • (2008) Biochem. Biophys. Res. Commun , vol.373 , pp. 539-544
    • Kang, M.K.1    Kang, S.K.2
  • 43
    • 65449126350 scopus 로고    scopus 로고
    • Present and potential future adjuvant issues in high-grade astrocytic glioma treatment
    • Lefranc, F., Rynkowski, M., DeWitte, O., and Kiss, R. (2009). Present and potential future adjuvant issues in high-grade astrocytic glioma treatment. Adv. Tech. Stand. Neurosurg. 34, 3-35. doi: 10.1007/978-3-211-78741-0_1
    • (2009) Adv. Tech. Stand. Neurosurg , vol.34 , pp. 3-35
    • Lefranc, F.1    Rynkowski, M.2    DeWitte, O.3    Kiss, R.4
  • 44
    • 0033932651 scopus 로고    scopus 로고
    • Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition
    • Li, W. E., and Nagy, J. I. (2000). Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition. Eur. J. Neurosci. 12, 2644-2650. doi: 10.1046/j.1460-9568.2000.00162.x
    • (2000) Eur. J. Neurosci , vol.12 , pp. 2644-2650
    • Li, W.E.1    Nagy, J.I.2
  • 45
    • 0036523097 scopus 로고    scopus 로고
    • Cloning and characterization of glioma BK, a novel BK channel isoform highly expressed in human glioma cells
    • Liu, X., Chang, Y., Reinhart, P. H., Sontheimer, H., and Chang, Y. (2002). Cloning and characterization of glioma BK, a novel BK channel isoform highly expressed in human glioma cells. J. Neurosci. 22, 1840-1849.
    • (2002) J. Neurosci , vol.22 , pp. 1840-1849
    • Liu, X.1    Chang, Y.2    Reinhart, P.H.3    Sontheimer, H.4    Chang, Y.5
  • 46
    • 78650777663 scopus 로고    scopus 로고
    • Basolateral potassium (IKCa) channel inhibition prevents increased colonic permeability induced by chemical hypoxia
    • Loganathan, A., Linley, J. E., Rajput, I., Hunter, M., Lodge, J. P., and Sandle, G. I. (2011). Basolateral potassium (IKCa) channel inhibition prevents increased colonic permeability induced by chemical hypoxia. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G146-G153. doi: 10.1152/ajpgi.00472.2009
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol , vol.300 , pp. G146-G153
    • Loganathan, A.1    Linley, J.E.2    Rajput, I.3    Hunter, M.4    Lodge, J.P.5    Sandle, G.I.6
  • 47
    • 0023783451 scopus 로고
    • Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells
    • López-Barneo, J., López-López, J. R., Ureña, J., and González, C. (1988). Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells. Science 241, 580-582. doi: 10.1126/science.2456613
    • (1988) Science , vol.241 , pp. 580-582
    • López-Barneo, J.1    López-López, J.R.2    Ureña, J.3    González, C.4
  • 48
    • 29144466617 scopus 로고    scopus 로고
    • A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits
    • McCartney, C. E., McClafferty, H., Huibant, J. M., Rowan, E. G., Shipston, M. J., and Rowe, I. C. (2005). A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits. Proc. Natl. Acad. Sci. U S A 102, 17870-17876. doi: 10.1073/pnas.0505270102
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 17870-17876
    • McCartney, C.E.1    McClafferty, H.2    Huibant, J.M.3    Rowan, E.G.4    Shipston, M.J.5    Rowe, I.C.6
  • 49
    • 32644472807 scopus 로고    scopus 로고
    • A role for ion channels in glioma cell invasion
    • McFerrin, M. B., and Sontheimer, H. (2006). A role for ion channels in glioma cell invasion. Neuron Glia Biol. 2, 39-49. doi: 10.1017/s1740925x06000044
    • (2006) Neuron Glia Biol , vol.2 , pp. 39-49
    • McFerrin, M.B.1    Sontheimer, H.2
  • 50
    • 84869210513 scopus 로고    scopus 로고
    • Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death
    • McFerrin, M. B., Turner, K. L., Cuddapah, V. A., and Sontheimer, H. (2012). Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death. Am. J. Physiol. Cell Physiol. 303, C1070-C1078. doi: 10.1152/ajpcell.00040.2012
    • (2012) Am. J. Physiol. Cell Physiol , vol.303 , pp. C1070-C1078
    • McFerrin, M.B.1    Turner, K.L.2    Cuddapah, V.A.3    Sontheimer, H.4
  • 51
    • 77952863838 scopus 로고    scopus 로고
    • Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres
    • Méndez, O., Zavadil, J., Esencay, M., Lukyanov, Y., Santovasi, D., Wang, S. C., et al. (2010). Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Mol. Cancer 9:133. doi: 10.1186/1476-4598-9-133
    • (2010) Mol. Cancer , vol.9 , pp. 133
    • Méndez, O.1    Zavadil, J.2    Esencay, M.3    Lukyanov, Y.4    Santovasi, D.5    Wang, S.C.6
  • 52
    • 34347206794 scopus 로고    scopus 로고
    • Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells
    • Merighi, S., Benini, A., Mirandola, P., Gessi, S., Varani, K., Leung, E., et al. (2007). Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells. Mol. Pharmacol. 72, 162-172. doi: 10.1124/mol.106.031849
    • (2007) Mol. Pharmacol , vol.72 , pp. 162-172
    • Merighi, S.1    Benini, A.2    Mirandola, P.3    Gessi, S.4    Varani, K.5    Leung, E.6
  • 53
    • 84883191664 scopus 로고    scopus 로고
    • STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion
    • Motiani, R. K., Hyzinski-García, M. C., Zhang, X., Henkel, M. M., Abdullaev, I. F., Kuo, Y. H., et al. (2013). STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion. Pflugers Arch. 465, 1249-1260. doi: 10.1007/s00424-013-1254-8
    • (2013) Pflugers Arch , vol.465 , pp. 1249-1260
    • Motiani, R.K.1    Hyzinski-García, M.C.2    Zhang, X.3    Henkel, M.M.4    Abdullaev, I.F.5    Kuo, Y.H.6
  • 54
    • 77952929243 scopus 로고    scopus 로고
    • Implications and challenges of connexin connections to cancer
    • Naus, C. C., and Laird, D. W. (2010). Implications and challenges of connexin connections to cancer. Nat. Rev. Cancer 10, 435-441. doi: 10.1038/nrc2841
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 435-441
    • Naus, C.C.1    Laird, D.W.2
  • 55
    • 77953767072 scopus 로고    scopus 로고
    • Hypoxia and the malignant glioma microenvironment: Regulation and implications for therapy
    • Oliver, L., Olivier, C., Marhuenda, F. B., Campone, M., and Vallette, F. M. (2009). Hypoxia and the malignant glioma microenvironment: regulation and implications for therapy. Curr. Mol. Pharmacol. 2, 263-284. doi: 10.2174/1874467210902030263
    • (2009) Curr. Mol. Pharmacol , vol.2 , pp. 263-284
    • Oliver, L.1    Olivier, C.2    Marhuenda, F.B.3    Campone, M.4    Vallette, F.M.5
  • 56
    • 0038383958 scopus 로고    scopus 로고
    • Expression of voltage-gated chloride channels in human glioma cells
    • Olsen, M. L., Schade, S., Lyons, S. A., Amaral, M. D., and Sontheimer, H. (2003). Expression of voltage-gated chloride channels in human glioma cells. J. Neurosci. 23, 5572-5582.
    • (2003) J. Neurosci , vol.23 , pp. 5572-5582
    • Olsen, M.L.1    Schade, S.2    Lyons, S.A.3    Amaral, M.D.4    Sontheimer, H.5
  • 57
    • 33748995139 scopus 로고    scopus 로고
    • Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways
    • Park, C. M., Park, M. J., Kwak, H. J., Lee, H. C., Kim, M. S., Lee, S. H., et al. (2006). Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways. Cancer Res. 66, 8511-8519. doi: 10.1158/0008-5472.can-05-4340
    • (2006) Cancer Res , vol.66 , pp. 8511-8519
    • Park, C.M.1    Park, M.J.2    Kwak, H.J.3    Lee, H.C.4    Kim, M.S.5    Lee, S.H.6
  • 58
    • 0032079536 scopus 로고    scopus 로고
    • Disruption of mitochondrial respiration inhibits volume-regulated anion channels and provokes neuronal cell swelling
    • Patel, A. J., Lauritzen, I., Lazdunski, M., and Honoré, E. (1998). Disruption of mitochondrial respiration inhibits volume-regulated anion channels and provokes neuronal cell swelling. J. Neurosci. 18, 3117-3123.
    • (1998) J. Neurosci , vol.18 , pp. 3117-3123
    • Patel, A.J.1    Lauritzen, I.2    Lazdunski, M.3    Honoré, E.4
  • 59
    • 84888375596 scopus 로고    scopus 로고
    • Acute hypoxia activates store-operated Ca(2+) entry and increases intracellular Ca(2+) concentration in rat distal pulmonary venous smooth muscle cells
    • Peng, G., Ran, P., Lu, W., Zhong, N., and Wang, J. (2013). Acute hypoxia activates store-operated Ca(2+) entry and increases intracellular Ca(2+) concentration in rat distal pulmonary venous smooth muscle cells. J. Thorac. Dis. 5, 605-612. doi: 10.3978/j.issn.2072-1439.2013.08.68
    • (2013) J. Thorac. Dis , vol.5 , pp. 605-612
    • Peng, G.1    Ran, P.2    Lu, W.3    Zhong, N.4    Wang, J.5
  • 60
    • 0036554937 scopus 로고    scopus 로고
    • Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023
    • Qian, L. W., Mizumoto, K., Urashima, T., Nagai, E., Maehara, N., Sato, N., et al. (2002). Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023. Clin. Cancer Res. 8, 1223-1227.
    • (2002) Clin. Cancer Res , vol.8 , pp. 1223-1227
    • Qian, L.W.1    Mizumoto, K.2    Urashima, T.3    Nagai, E.4    Maehara, N.5    Sato, N.6
  • 61
    • 33646590328 scopus 로고    scopus 로고
    • Oxygen tension modulates the expression of pulmonary vascular BKCa channel alpha- and beta-subunits
    • Resnik, E., Herron, J., Fu, R., Ivy, D. D., and Cornfield, D. N. (2006). Oxygen tension modulates the expression of pulmonary vascular BKCa channel alpha- and beta-subunits. Am. J. Physiol. Lung. Cell. Mol. Physiol. 290, L761-L768. doi: 10.1152/ajplung.00283.2005
    • (2006) Am. J. Physiol. Lung. Cell. Mol. Physiol , vol.290 , pp. L761-L768
    • Resnik, E.1    Herron, J.2    Fu, R.3    Ivy, D.D.4    Cornfield, D.N.5
  • 62
    • 0035980165 scopus 로고    scopus 로고
    • O(2) modulates large-conductance Ca(2+)-dependent K(+) channels of rat chemoreceptor cells by a membrane restricted and CO-sensitive mechanism
    • Riesco-Fagundo, A. M., Pérez-García, M. T., González, C., and López-López, J. R. (2001). O(2) modulates large-conductance Ca(2+)-dependent K(+) channels of rat chemoreceptor cells by a membrane restricted and CO-sensitive mechanism. Circ. Res. 89, 430-436. doi: 10.1161/hh1701.095632
    • (2001) Circ. Res , vol.89 , pp. 430-436
    • Riesco-Fagundo, A.M.1    Pérez-García, M.T.2    González, C.3    López-López, J.R.4
  • 63
    • 77951228221 scopus 로고    scopus 로고
    • Wilms tumor suppressor 1 (WT1) and early growth response 1 (EGR1) are regulators of STIM1 expression
    • Ritchie, M. F., Yue, C., Zhou, Y., Houghton, P. J., and Soboloff, J. (2010). Wilms tumor suppressor 1 (WT1) and early growth response 1 (EGR1) are regulators of STIM1 expression. J. Biol. Chem. 285, 10591-10596. doi: 10.1074/jbc.m109.083493
    • (2010) J. Biol. Chem , vol.285 , pp. 10591-10596
    • Ritchie, M.F.1    Yue, C.2    Zhou, Y.3    Houghton, P.J.4    Soboloff, J.5
  • 64
    • 33746696738 scopus 로고    scopus 로고
    • "Pseudopalisading" necrosis in glioblastoma: A familiar morphologic feature that links vascular pathology, hypoxia and angiogenesis
    • Rong, Y., Durden, D. L., Van Meir, E. G., and Brat, D. J. (2006). "Pseudopalisading" necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia and angiogenesis. J. Neuropathol. Exp. Neurol.65, 529-539. doi: 10.1097/00005072-200606000-00001
    • (2006) J. Neuropathol. Exp. Neurol , vol.65 , pp. 529-539
    • Rong, Y.1    Durden, D.L.2    Van Meir, E.G.3    Brat, D.J.4
  • 65
    • 84861326960 scopus 로고    scopus 로고
    • Functional role of T-type calcium channels in tumour growth and progression: Prospective in cancer therapy
    • Santoni, G., Santoni, M., and Nabissi, M. (2012). Functional role of T-type calcium channels in tumour growth and progression: prospective in cancer therapy. Br. J. Pharmacol. 166, 1244-1246. doi: 10.1111/j.1476-5381.2012.01908.x
    • (2012) Br. J. Pharmacol , vol.166 , pp. 1244-1246
    • Santoni, G.1    Santoni, M.2    Nabissi, M.3
  • 66
    • 84861530654 scopus 로고    scopus 로고
    • Oxygen-Dependent gene expression in development and cancer: Lessons learned from the wilms' tumor gene, WT1
    • Scholz, H., and Kirschner, K. M. (2011). Oxygen-Dependent gene expression in development and cancer: lessons learned from the wilms' tumor gene, WT1. Front. Mol. Neurosci. 4:4. doi: 10.3389/fnmol.2011.00004
    • (2011) Front. Mol. Neurosci , vol.4 , pp. 4
    • Scholz, H.1    Kirschner, K.M.2
  • 67
    • 77953794483 scopus 로고    scopus 로고
    • CXCL12-induced glioblastoma cell migration requires intermediate conductance Ca2+-activated K+ channel activity
    • Sciaccaluga, M., Fioretti, B., Catacuzzeno, L., Pagani, F., Bertollini, C., Rosito, M., et al. (2010). CXCL12-induced glioblastoma cell migration requires intermediate conductance Ca2+-activated K+ channel activity. Am. J. Physiol. Cell Physiol. 299, C175-C184. doi: 10.1152/ajpcell.00344.2009
    • (2010) Am. J. Physiol. Cell Physiol , vol.299 , pp. C175-C184
    • Sciaccaluga, M.1    Fioretti, B.2    Catacuzzeno, L.3    Pagani, F.4    Bertollini, C.5    Rosito, M.6
  • 68
    • 84874734554 scopus 로고    scopus 로고
    • Reversible atrial gap junction remodeling during hypoxia/reoxygenation and ischemia: A possible arrhythmogenic substrate for atrial fibrillation
    • Severino, A., Narducci, M. L., Pedicino, D., Pazzano, V., Giglio, A. F., Biasucci, L. M., et al. (2012). Reversible atrial gap junction remodeling during hypoxia/reoxygenation and ischemia: a possible arrhythmogenic substrate for atrial fibrillation. Gen. Physiol. Biophys. 31, 439-448. doi: 10.4149/gpb_2012_047
    • (2012) Gen. Physiol. Biophys , vol.31 , pp. 439-448
    • Severino, A.1    Narducci, M.L.2    Pedicino, D.3    Pazzano, V.4    Giglio, A.F.5    Biasucci, L.M.6
  • 69
    • 84879693403 scopus 로고    scopus 로고
    • Effect of silencing HIF-1α on proliferation, invasion and migration of glioblastoma U87 cells
    • Shen, S. H., Kwan, A. L., Chen, Y. Y., and Wang, Z. X. (2013). Effect of silencing HIF-1α on proliferation, invasion and migration of glioblastoma U87 cells. Neurol. Sci. 34, 365-371. doi: 10.1007/s10072-012-1010-4
    • (2013) Neurol. Sci , vol.34 , pp. 365-371
    • Shen, S.H.1    Kwan, A.L.2    Chen, Y.Y.3    Wang, Z.X.4
  • 70
    • 79955558300 scopus 로고    scopus 로고
    • Hypoxia. 4. Hypoxia and ion channel function
    • Shimoda, L. A., and Polak, J. (2011). Hypoxia. 4. Hypoxia and ion channel function. Am. J. Physiol. Cell Physiol.300, C951-C967. doi: 10.1152/ajpcell.00512.2010
    • (2011) Am. J. Physiol. Cell Physiol , vol.300 , pp. C951-C967
    • Shimoda, L.A.1    Polak, J.2
  • 71
    • 0031765429 scopus 로고    scopus 로고
    • Diverse functions of vertebrate gap junctions
    • Simon, A. M., and Goodenough, D. A. (1998). Diverse functions of vertebrate gap junctions. Trends Cell Biol. 8, 477-483. doi: 10.1016/s0962-8924(98)01372-5
    • (1998) Trends Cell Biol , vol.8 , pp. 477-483
    • Simon, A.M.1    Goodenough, D.A.2
  • 72
    • 2542479034 scopus 로고    scopus 로고
    • Ion channels and amino acid transporters support the growth and invasion of primary brain tumors
    • Sontheimer, H. (2004). Ion channels and amino acid transporters support the growth and invasion of primary brain tumors. Mol. Neurobiol. 29, 61-71. doi: 10.1385/mn:29:1:61
    • (2004) Mol. Neurobiol , vol.29 , pp. 61-71
    • Sontheimer, H.1
  • 73
    • 47749110251 scopus 로고    scopus 로고
    • An unexpected role for ion channels in brain tumor metastasis
    • Sontheimer, H. (2008). An unexpected role for ion channels in brain tumor metastasis. Exp. Biol. Med. (Maywood)233, 779-791. doi: 10.3181/0711-mr-308
    • (2008) Exp. Biol. Med. (Maywood) , vol.233 , pp. 779-791
    • Sontheimer, H.1
  • 74
    • 52049120148 scopus 로고    scopus 로고
    • Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: Correlation with time to progression and survival
    • Spence, A. M., Muzi, M., Swanson, K. R., O'Sullivan, F., Rockhill, J. K., Rajendran, J. G., et al. (2008). Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival. Clin. Cancer Res. 14, 2623-2630. doi: 10.1158/1078-0432.ccr-07-4995
    • (2008) Clin. Cancer Res , vol.14 , pp. 2623-2630
    • Spence, A.M.1    Muzi, M.2    Swanson, K.R.3    O'Sullivan, F.4    Rockhill, J.K.5    Rajendran, J.G.6
  • 75
    • 80655127838 scopus 로고    scopus 로고
    • Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels
    • Steinle, M., Palme, D., Misovic, M., Rudner, J., Dittmann, K., Lukowski, R., et al. (2011). Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels. Radiother. Oncol. 101, 122-126. doi: 10.1016/j.radonc.2011.05.069
    • (2011) Radiother. Oncol , vol.101 , pp. 122-126
    • Steinle, M.1    Palme, D.2    Misovic, M.3    Rudner, J.4    Dittmann, K.5    Lukowski, R.6
  • 76
    • 85006951047 scopus 로고    scopus 로고
    • Suppression of chloride channel 3 expression facilitates sensitivity of human glioma U251 cells to cisplatin through concomitant inhibition of Akt and autophagy
    • Su, J., Xu, Y., Zhou, L., Yu, H. M., Kang, J. S., Liu, N., et al. (2013). Suppression of chloride channel 3 expression facilitates sensitivity of human glioma U251 cells to cisplatin through concomitant inhibition of Akt and autophagy.Anat. Rec. (Hoboken) 296, 595-603. doi: 10.1002/ar.22665
    • (2013) Anat. Rec. (Hoboken) , vol.296 , pp. 595-603
    • Su, J.1    Xu, Y.2    Zhou, L.3    Yu, H.M.4    Kang, J.S.5    Liu, N.6
  • 77
    • 84864297897 scopus 로고    scopus 로고
    • Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: A mechanism contributing to enhanced vasoreactivity
    • Sun, H., Xia, Y., Paudel, O., Yang, X. R., and Sham, J. S. (2012). Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity. J. Physiol. 590, 3507-3521. doi: 10.1113/jphysiol.2012.232520
    • (2012) J. Physiol , vol.590 , pp. 3507-3521
    • Sun, H.1    Xia, Y.2    Paudel, O.3    Yang, X.R.4    Sham, J.S.5
  • 78
    • 84893466731 scopus 로고    scopus 로고
    • Cl- and K+ channels and their role in primary brain tumour biology
    • Turner, K. L., and Sontheimer, H. (2014). Cl- and K+ channels and their role in primary brain tumour biology.Philos. Trans. R. Soc. Lond. B Biol. Sci. 369:20130095. doi: 10.1098/rstb.2013.0095
    • (2014) Philos. Trans. R. Soc. Lond. B Biol. Sci , vol.369
    • Turner, K.L.1    Sontheimer, H.2
  • 79
    • 84874658596 scopus 로고    scopus 로고
    • Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells
    • Valerie, N. C., Dziegielewska, B., Hosing, A. S., Augustin, E., Gray, L. S., Brautigan, D. L., et al. (2013). Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells. Biochem. Pharmacol.85, 888-897. doi: 10.1016/j.bcp.2012.12.017
    • (2013) Biochem. Pharmacol , vol.85 , pp. 888-897
    • Valerie, N.C.1    Dziegielewska, B.2    Hosing, A.S.3    Augustin, E.4    Gray, L.S.5    Brautigan, D.L.6
  • 80
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel, P. (2004). Tumor microenvironmental physiology and its implications for radiation oncology. Semin. Radiat. Oncol. 14, 198-206. doi: 10.1016/j.semradonc.2004.04.008
    • (2004) Semin. Radiat. Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 81
    • 0035677961 scopus 로고    scopus 로고
    • Treatment resistance of solid tumors: Role of hypoxia and anemia
    • Vaupel, P., Thews, O., and Hoeckel, M. (2001). Treatment resistance of solid tumors: role of hypoxia and anemia.Med. Oncol. 18, 243-259. doi: 10.1385/mo:18:4:243
    • (2001) Med. Oncol , vol.18 , pp. 243-259
    • Vaupel, P.1    Thews, O.2    Hoeckel, M.3
  • 82
    • 53849129519 scopus 로고    scopus 로고
    • Functional expression of transient receptor potential vanilloid-related channels in chronically hypoxic human pulmonary arterial smooth muscle cells
    • Wang, Y. X., Wang, J., Wang, C., Liu, J., Shi, L. P., Xu, M., et al. (2008). Functional expression of transient receptor potential vanilloid-related channels in chronically hypoxic human pulmonary arterial smooth muscle cells. J. Membr. Biol. 223, 151-159. doi: 10.1007/s00232-008-9121-9
    • (2008) J. Membr. Biol , vol.223 , pp. 151-159
    • Wang, Y.X.1    Wang, J.2    Wang, C.3    Liu, J.4    Shi, L.P.5    Xu, M.6
  • 83
    • 0035866813 scopus 로고    scopus 로고
    • Sublethal irradiation promotes migration and invasiveness of glioma cells: Implications for radiotherapy of human glioblastoma
    • Wild-Bode, C., Weller, M., Rimner, A., Dichgans, J., and Wick, W. (2001). Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. Cancer Res. 61, 2744-2750.
    • (2001) Cancer Res , vol.61 , pp. 2744-2750
    • Wild-Bode, C.1    Weller, M.2    Rimner, A.3    Dichgans, J.4    Wick, W.5
  • 84
    • 10844248490 scopus 로고    scopus 로고
    • Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel
    • Williams, S. E., Wootton, P., Mason, H. S., Bould, J., Iles, D. E., Riccardi, D., et al. (2004). Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science 306, 2093-2097. doi: 10.1126/science.1105010
    • (2004) Science , vol.306 , pp. 2093-2097
    • Williams, S.E.1    Wootton, P.2    Mason, H.S.3    Bould, J.4    Iles, D.E.5    Riccardi, D.6
  • 85
    • 70350638630 scopus 로고    scopus 로고
    • Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration
    • Wondergem, R., and Bartley, J. W. (2009). Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration. J. Biomed. Sci. 16:90. doi: 10.1186/1423-0127-16-90
    • (2009) J. Biomed. Sci , vol.16 , pp. 90
    • Wondergem, R.1    Bartley, J.W.2
  • 86
    • 84889096460 scopus 로고    scopus 로고
    • Hypoxia induces connexin 43 dysregulation by modulating matrix metalloproteinases via MAPK signaling
    • Wu, X., Huang, W., Luo, G., and Alain, L. A. (2013). Hypoxia induces connexin 43 dysregulation by modulating matrix metalloproteinases via MAPK signaling. Mol. Cell. Biochem. 384, 155-162. doi: 10.1007/s11010-013-1793-5
    • (2013) Mol. Cell. Biochem , vol.384 , pp. 155-162
    • Wu, X.1    Huang, W.2    Luo, G.3    Alain, L.A.4
  • 87
    • 84866340817 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications
    • Yang, L., Lin, C., Wang, L., Guo, H., and Wang, X. (2012). Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications. Exp. Cell Res. 318, 2417-2426. doi: 10.1016/j.yexcr.2012.07.017
    • (2012) Exp. Cell Res , vol.318 , pp. 2417-2426
    • Yang, L.1    Lin, C.2    Wang, L.3    Guo, H.4    Wang, X.5
  • 88
    • 84885173431 scopus 로고    scopus 로고
    • Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α
    • Zhang, Y., Liu, Q., Wang, F., Ling, E. A., Liu, S., Wang, L., et al. (2013). Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α. J. Pineal Res. 55, 121-130. doi: 10.1111/jpi.12052
    • (2013) J. Pineal Res , vol.55 , pp. 121-130
    • Zhang, Y.1    Liu, Q.2    Wang, F.3    Ling, E.A.4    Liu, S.5    Wang, L.6
  • 89
    • 84859572959 scopus 로고    scopus 로고
    • Chronic hypoxia in cultured human podocytes inhibits BKCa channels by upregulating its β4-subunit
    • Zhang, R., Sun, H., Liao, C., Yang, H., Zhao, B., Tian, J., et al. (2012a). Chronic hypoxia in cultured human podocytes inhibits BKCa channels by upregulating its β4-subunit. Biochem. Biophys. Res. Commun. 420, 505-510. doi: 10.1016/j.bbrc.2012.03.021
    • (2012) Biochem. Biophys. Res. Commun , vol.420 , pp. 505-510
    • Zhang, R.1    Sun, H.2    Liao, C.3    Yang, H.4    Zhao, B.5    Tian, J.6
  • 90
    • 84861320649 scopus 로고    scopus 로고
    • Inhibition of T-type Ca2+ channels by endostatin attenuates human glioblastoma cell proliferation and migration
    • Zhang, Y., Zhang, J., Jiang, D., Zhang, D., Qian, Z., Liu, C., et al. (2012b). Inhibition of T-type Ca2+ channels by endostatin attenuates human glioblastoma cell proliferation and migration. Br. J. Pharmacol. 166, 1247-1260. doi: 10.1111/j.1476-5381.2012.01852.x
    • (2012) Br. J. Pharmacol , vol.166 , pp. 1247-1260
    • Zhang, Y.1    Zhang, J.2    Jiang, D.3    Zhang, D.4    Qian, Z.5    Liu, C.6


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