Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells

Biochemical Pharmacology

Volumn 85, Issue 7, 2013, Pages 888-897

  Valerie, Nicholas C K ^a   Dziegielewska, Barbara ^a   Hosing, Amol S ^a   Augustin, Ewa ^b   Gray, Lloyd S ^c   Brautigan, David L ^d,e   Larner, James M ^a,e   Dziegielewski, Jaroslaw ^a,e  

^a UNIVERSITY OF VIRGINIA   (United States)

^b GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^c Tau Therapeutics LLC   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Akt; Apoptosis; Glioblastoma multiforme; Mibefradil; mTORC2; T type calcium channels

Indexed keywords

CALCIUM CHANNEL T TYPE; CASPASE; MIBEFRADIL; PROTEIN BAD; PROTEIN KINASE B; SMALL INTERFERING RNA;

ALPHA CHAIN; APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CYTOTOXICITY; ENZYME ACTIVATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOLECULARLY TARGETED THERAPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BRAIN NEOPLASMS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELL LINE, TUMOR; CELL SURVIVAL; GLIOBLASTOMA; HUMANS; MIBEFRADIL; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION-SENSITIZING AGENTS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84874658596     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.12.017     Document Type: Article

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