HUWE1ubiquitylates and degrades the rac activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion

Cell Reports

Volumn 10, Issue 1, 2015, Pages 88-102

  Vaughan, Lynsey ^a   Tan, Chong Teik ^a   Chapman, Anna ^b   Nonaka, Daisuke ^b   Mack, Natalie A ^a   Smith, Duncan ^a   Booton, Richard ^c   Hurlstone, Adam F L ^b   Malliri, Angeliki ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c Institute of Inflammation and Repair   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE RAC; HECT UBA AND WWE DOMAIN CONTAINING PROTEIN 1; MESSENGER RNA; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; T LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; HUWE1 PROTEIN, HUMAN; RAC PROTEIN; TIAM1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; BIOACCUMULATION; CANCER GROWTH; CANCER STAGING; CELL ADHESION; CELL INVASION; CELL JUNCTION DISASSEMBLY; CELL MIGRATION; CELL MOTILITY; CELL SCATTERING; CELL STIMULATION; CELLULAR DISTRIBUTION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; INTRACELLULAR SIGNALING; LUNG CANCER CELL LINE; LUNG CARCINOGENESIS; MAJOR CLINICAL STUDY; MDCK CELL LINE; MOLECULAR DYNAMICS; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SQUAMOUS CELL LUNG CARCINOMA; UBIQUITINATION; ANIMAL; CARCINOGENESIS; CELL MOTION; DOG; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR INVASION;

ANIMALS; CARCINOGENESIS; CELL ADHESION; CELL MOVEMENT; DOGS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LUNG NEOPLASMS; MADIN DARBY CANINE KIDNEY CELLS; NEOPLASM INVASIVENESS; PROTEOLYSIS; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84920920172     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.12.012     Document Type: Article

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