Degradation of Tiaml by casein kinase 1 and the SCFßTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling

Journal of Biological Chemistry

Volumn 289, Issue 40, 2014, Pages 27400-27409

  Magliozzi, Roberto ^a   Kim, Jihoon ^a   Low, Teck Yew ^b,c   Heck, Albert J R ^b,c   Guardavaccaro, Daniele ^a,d  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^d HUBRECHT INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE; UBIQUITIN LIGASES;

CASEIN KINASE I; F BOX PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGENIC AGENT; PROTEASOME; S6 KINASE; T CELL LYMPHOMA INVASION AND METASTASIS 1; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE SCF BETA TRCP; UNCLASSIFIED DRUG; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; PROTEIN BINDING; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 2; TARGET OF RAPAMYCIN KINASE; TIAM1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE MUTATION; GENE SILENCING; MITOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION;

BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CASEIN KINASE I; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; PHOSPHORYLATION; PROTEIN BINDING; PROTEOLYSIS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TOR SERINE-THREONINE KINASES;

EID: 84907482247     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.575571     Document Type: Article

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