Inhibition of proliferation and differentiation and promotion of apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells

Biochemical and Biophysical Research Communications

Volumn 390, Issue 3, 2009, Pages 451-457

  Zhuo, Lili ^a   Gong, Jie ^a   Yang, Rong ^a   Sheng, Yanhui ^a   Zhou, Lei ^a   Kong, Xiangqing ^a   Cao, Kejiang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Congenital heart defects; Cyclin L2; Differentiation; Proliferation; Wnt signaling

Indexed keywords

BETA CATENIN; CYCLIN L2; CYCLINE; DIMETHYL SULFOXIDE; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN BCL 2; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYONAL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARCINOMA, EMBRYONAL; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLINS; GENE EXPRESSION REGULATION, NEOPLASTIC; MICE; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 70449699611     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.09.089     Document Type: Article

References (36)

1. Gelb B.D. Genetic basis of congenital heart disease. Curr. Opin. Cardiol. 19 (2004) 110-115
2. Kaynak B., von Heydebreck A., Mebus S., Seelow D., Hennig S., Vogel J., Sperling H.P., Pregla R., Alexi-Meskishvili V., Hetzer R., Lange P.E., Vingron M., Lehrach H., and Sperling S. Genome-wide array analysis of normal and malformed human hearts. Circulation 107 (2003) 2467-2474
3. Zhu H., Kartiko S., and Finnell R.H. Importance of gene-environment interactions in the etiology of selected birth defects. Clin. Genet. 75 (2009) 409-423
4. Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., and Bakkers J. Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 119 (2009) 3062-3069
5. Schott J.J., Benson D.W., Basson C.T., Pease W., Silberbach G.M., Moak J.P., Maron B.J., Seidman C.E., and Seidman J.G. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 281 (1998) 108-111
6. Elliott D.A., Kirk E.P., Yeoh T., Chandar S., McKenzie F., Taylor P., Grossfeld P., Fatkin D., Jones O., Hayes P., Feneley M., and Harvey R.P. Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. J. Am. Coll. Cardiol. 41 (2003) 2072-2076
7. Garg V., Kathiriya I.S., Barnes R., Schluterman M.K., King I.N., Butler C.A., Rothroc C.R., Eapen R.S., Hirayama-Yamada K., Joo K., Matsuoka R., Cohen J.C., and Srivastava D. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 424 (2003) 443-447
8. Okubo A., Miyoshi O., Baba K., Takagi M., Tsukamoto K., Kinoshita A., Yoshiura K., Kishino T., Ohta T., Niikawa N., and Matsumoto N. A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family. J. Med. Genet. 41 (2004) e97
9. Basson C.T., Bachinsky D.R., Lin R.C., Levi T., Elkins J.A., Soults J., Grayzel D., Kroumpouzou E., Traill T.A., Leblanc-Straceski J., Renault B., Kucherlapati R., Seidman J.G., and Seidman C.E. Mutations inhuman TBX5 cause limb and cardiac malformation in Holt-Oram syndrome. Nat. Genet. 15 (1997) 30-35
10. Li Q.Y., Newbury-Ecob R.A., Terrett J.A., Wilson D.I., Curtis A.R., Yi C.H., Gebuhr T., Bullen P.J., Robson S.C., Strachan T., Bonnet D., Lyonnet S., Young I.D., Raeburn J.A., Buckler A.J., Law D.J., and Brook J.D. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat. Genet. 15 (1997) 21-29
11. Qian L.M., Cao K.J., Huang Y.Z., Kong X.Q., and Shan Q.J. Preliminary analysis of gene expression profiles in human myocardium of atrial septal defect by cDNA microarray. Chin J. Cardiol. 31 (2003) 180-183
12. Zhang H., Zhou L., Yang R., Sheng Y., Sun W., Kong X., and Cao K. Identification of differentially expressed genes in human heart with ventricular septal defect using suppression subtractive hybridization. Biochem. Biophys. Res. Commun. 342 (2006) 135-144
13. Grepin C., Nemer G., and Nemer M. Enhanced cardiogenesis in embryonic stem cells overexpressing the CATA4 transcription factor. Development 124 (1997) 2387-2395
14. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
15. Tanaka T., Tomaru Y., Nomura Y., Miura H., Suzuki M., and Hayashizaki Y. Comprehensive search for HNF-1β-regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor-targeted RNAi. Nucleic Acids Res. 32 (2004) 2740-2750
16. Olivera A., Kohama T., Edsall L., Nava V., Cuvillier O., Poulton S., and Spiegel S. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J. Cell Biol. 147 (1999) 545-558
17. Wasch R., and Cross F.R. APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418 (2002) 556-562
18. Duman-Scheel M., Weng L., Xin S., and Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417 (2002) 299-304
19. Koepp D.M., Schaefer L.K., Ye X., Keyomarsi K., Chu C., Harper J.W., and Elledge S.J. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294 (2001) 173-177
20. Nguyen V.T., Kiss T., Michels A.A., and Bensaude O. 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature 414 (2001) 322-325
21. Miller M.E., and Cross F.R. Cyclin specificity: how many wheels do you need on a unicycle?. J. Cell Sci. 114 (2001) 1811-1820
22. Loyer P., Trembley J.H., Katona R., Kidd V.J., and Lahti J.M. Role of CDK/cyclin complexes in transcription and RNA splicing. Cell. Signal. 17 (2005) 1033-1051
23. Shin C., and Manley J.L. Cell signaling and the control of pre-mRNA splicing. Nat. Rev. Mol. Cell Biol. 5 (2004) 727-738
24. Regman D.B., Pestell R.G., and Kidd V.J. Cell cycle regulation and RNA polymerase II. Front. Biosci. 5 (2000) D244-D257
25. Mori T., Anazawa Y., Matsui K., Fukuda S., Nakamura Y., and Arakawa H. Cyclin K as a direct transcriptional target of the p53 tumor suppressor. Neoplasia 4 (2002) 268-274
26. Redon R., Hussenet T., Bour G., Caulee K., Jost B., Muller D., Abecassis J., and du Manoir S. Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer. Cancer Res. 62 (2002) 6211-6217
27. de Graaf K., Hekerman P., Spelten O., Herrmann A., Packman L.C., Bussow K., Muller-Newen G., and Becker W. Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain. J. Biol. Chem. 279 (2004) 4612-4624
28. Zhao L., Samuels T., Winckler S., Korgaonkar C., Tompkins V., Horne M.C., and Quelle D.E. Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways. Mol. Cancer Res. 1 (2003) 195-206
29. Van der Heyden M.A., van Kempen M.J., Tsuji Y., Rook M.B., Jongsma H.J., and Opthof T. P19 embryonal carcinoma cells: a suitable model system for cardiac electrophysiological differentiation at the molecular and functional level. Cardiovasc. Res. 58 (2003) 410-422
30. van der Heyden M.A., and Defize L.H. Twenty one years of P19 cells: what an embryonal carcinoma cell line taught us about cardiomyocyte differentiation. Cardiovasc. Res. 58 (2003) 292-302
31. Yang L., Li N., Wang C., Yu Y., Yuan L., Zhang M., and Cao X. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. J. Biol. Chem. 279 (2004) 11639-11648
32. Li H.L., Wang T.S., Li X.Y., Li N., Huang D.Z., Chen Q., and Ba Y. Overexpression of cyclin L2 induces apoptosis and cell-cycle arrest in human lung cancer cells. Chin. Med. J. 120 (2007) 905-909
33. Kwon C., Cordes K.R., and Srivastava D. Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. Cell Cycle 7 (2008) 3815-3818
34. Cohen E.D., Tian Y., and Morrisey E.E. Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal. Development 135 (2008) 789-798
35. Rochais F., Mesbah K., and Kelly R.G. Signaling pathways controlling second heart field development. Circ. Res. 104 (2009) 933-942
36. Kwon C., Arnold J., Hsiao E.C., Taketo M.M., Conklin B.R., and Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc. Natl. Acad. Sci. USA 104 (2007) 10894-10899