Structural insight into the physical stability of amorphous Simvastatin dispersed in pHPMA: Enhanced dynamics and local clustering as evidenced by solid-state NMR and Raman spectroscopy

International Journal of Pharmaceutics

Volumn 478, Issue 2, 2015, Pages 464-475

  Urbanova, Martina ^a   Sturcova, Adriana ^a   Kredatusova, Jana ^a   Brus, Jiri ^a  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

Author keywords

Fluorescence; NMR; Pharmaceuticals; Raman spectroscopy; Simvastatin; Solid dispersions; Solid state

Indexed keywords

ESTER; LACTONE; NAPHTHALENE; POLY(2 HYDROXYPROPYL)METHACRYLAMIDE; POLYMER; SIMVASTATIN; UNCLASSIFIED DRUG; POLYMETHACRYLIC ACID DERIVATIVE; POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE]; WATER;

ARTICLE; DIFFUSION; DISPERSION; DRUG BIOAVAILABILITY; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; MOTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SOLID STATE; WATER ABSORPTION; ADSORPTION; CHEMICAL STRUCTURE; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY;

ADSORPTION; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STABILITY; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; POLYMETHACRYLIC ACIDS; SIMVASTATIN; SPECTRUM ANALYSIS, RAMAN; WATER;

EID: 84920849238     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.12.007     Document Type: Article

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