Solid-state acid-base interactions in complexes of heterocyclic bases with dicarboxylic acids: Crystallography, hydrogen bond analysis, and 15N NMR spectroscopy

Journal of the American Chemical Society

Volumn 128, Issue 25, 2006, Pages 8199-8210

  Li, Z Jane ^a   Abramov, Yuriy ^a   Bordner, Jon ^a   Leonard, Jason ^a,b   Medek, Ales ^a   Trask, Andrew V ^a,c  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Franklin Pierce Law Center   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CRYSTALLOGRAPHY; DRUG PRODUCTS; HYDROGEN BONDS; NITROGEN; NUCLEAR MAGNETIC RESONANCE; SOLUBILITY; TUMORS;

ACIDIC COMPONENTS; COMPLEXES; PHARMACEUTICAL DEVELOPMENT; PROTON-TRANSFER BEHAVIOR;

CARBOXYLIC ACIDS;

ACID; BASE; DICARBOXYLIC ACID;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; HYDROGEN BOND; NITROGEN NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

AMINES; CRYSTALLOGRAPHY, X-RAY; DICARBOXYLIC ACIDS; DRUG DESIGN; HETEROCYCLIC COMPOUNDS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NITROGEN ISOTOPES; RECEPTOR, ERBB-2; SOLUBILITY;

EID: 33745660776     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0541332     Document Type: Article

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