A stable amorphous statin: Solid-state NMR and dielectric studies on dynamic heterogeneity of simvastatin

Molecular Pharmaceutics

Volumn 11, Issue 3, 2014, Pages 727-737

  Nunes, Teresa G ^a   Viciosa, M Teresa ^a   Correia, Natália T ^b,c   Danede F ^b   Nunes, Rita G ^d   Diogo, Hermínio P ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b UNIVERSITÉ LILLE 1   (France)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^d UNIVERSITY OF LISBON   (Portugal)

Author keywords

amorphous simvastatin; DRS; DSC; solid state NMR; TGA

Indexed keywords

HYDROGEN; HYDROXYL GROUP; SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONFORMATION; CRYSTALLIZATION; DIELECTRIC RELAXATION SPECTROSCOPY; DRUG STABILITY; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; ENTHALPY; HYDROGEN BOND; IMMOBILIZATION; INFRARED SPECTROSCOPY; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SOLID STATE; THERMOGRAVIMETRY; THERMOSTABILITY; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THERMODYNAMICS;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DIELECTRIC SPECTROSCOPY; DRUG STABILITY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; SIMVASTATIN; THERMODYNAMICS; THERMOGRAVIMETRY;

EID: 84901743341     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400455r     Document Type: Article

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