Inhibition of notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4

Cell Cycle

Volumn 13, Issue 24, 2014, Pages 3857-3866

  Vega, Maria E ^a,b   Giroux, Véronique ^a,b   Natsuizaka, Mitsuteru ^a,b   Liu, Mingen ^a,b   Klein Szanto, Andres J ^c   Stairs, Douglas B ^d   Nakagawa, Hiroshi ^a,b   Wang, Kenneth K ^e   Wang, Timothy C ^f   Lynch, John P ^a,b   Rustgi, Anil K ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^e MAYO CLINIC   (United States)

^f Department of Medicine   (United States)

Author keywords

Barrett's esophagus; KLF4; Metaplasia; Notch signaling; Transdifferentiation

Indexed keywords

CYTOKERATIN 13; CYTOKERATIN 14; CYTOKERATIN 18; CYTOKERATIN 19; CYTOKERATIN 20; CYTOKERATIN 5; CYTOKERATIN 8; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; TRANSCRIPTION FACTOR CDX1; CALCIUM BINDING PROTEIN; CDX1 PROTEIN, HUMAN; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; JAG1 PROTEIN, HUMAN; KERATIN; KRUPPEL LIKE FACTOR; MAML1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MUCIN; MYC PROTEIN, HUMAN; NOTCH RECEPTOR; PROTEIN JAGGED 1; SERRATE JAGGED PROTEIN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

ARTICLE; BARRETT ESOPHAGUS; BASAL CELL; BASEMENT MEMBRANE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM BASAL CELL; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; TISSUE MICROARRAY; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL CULTURE TECHNIQUE; CELL LINE; CHEMISTRY; CYTOLOGY; EPITHELIUM CELL; ESOPHAGUS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METAPLASIA; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

BARRETT ESOPHAGUS; CALCIUM-BINDING PROTEINS; CELL CULTURE TECHNIQUES; CELL LINE; CELL TRANSDIFFERENTIATION; DNA-BINDING PROTEINS; EPITHELIAL CELLS; ESOPHAGUS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; JAGGED-1 PROTEIN; KERATINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEMBRANE PROTEINS; METAPLASIA; MUCINS; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, NOTCH; RNA INTERFERENCE; SERRATE-JAGGED PROTEINS; SIGNAL TRANSDUCTION; TISSUE ARRAY ANALYSIS; TRANSCRIPTION FACTORS;

EID: 84920730945     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/15384101.2014.972875     Document Type: Article

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