Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus

Laboratory Investigation

Volumn 92, Issue 6, 2012, Pages 896-909

  Tamagawa, Yuji ^a   Ishimura, Norihisa ^a   Uno, Goichi ^a   Yuki, Takafumi ^b   Kazumori, Hideaki ^a   Ishihara, Shunji ^a   Amano, Yuji ^b   Kinoshita, Yoshikazu ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b SHIMANE UNIVERSITY HOSPITAL   (Japan)

Author keywords

Barrett's esophagus; bile acids; Cdx2; Notch signaling pathway; TOH1

Indexed keywords

BILE ACID; MESSENGER RNA; MUCIN 2; NOTCH RECEPTOR; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR HES 1;

AGED; ARTICLE; BARRETT ESOPHAGUS; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ESOPHAGUS MUCOSA; FEMALE; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ADENOCARCINOMA; AGED; BARRETT ESOPHAGUS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CHOLIC ACID; DEOXYCHOLIC ACID; EPITHELIAL CELLS; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; FEMALE; GENE EXPRESSION; GENE SILENCING; GOBLET CELLS; HOMEODOMAIN PROTEINS; HUMANS; MALE; METAPLASIA; MUCIN-2; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, NOTCH1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84861618608     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.56     Document Type: Article

References (43)

1. Jankowski JA, Harrison RF, Perry I, et al. Barrett's metaplasia. Lancet 2000;356:2079-2085. (Pubitemid 32009828)
2. Paulson TG, Reid J. Focus on Barrett's esophagus and esophageal adenocarcinoma. Cancer cell 2004;6:11-16. (Pubitemid 38903158)
3. Cameron AJ, Zinsmeister AR, Ballard DJ, et al. Prevalence of columnarlined (Barrett's) esophagus. Gastroenterology 1990;99:918-922.
4. Blot WJ, Devessa SS, Kneller RW, et al. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991;265: 1287-1289.
5. Ronkainen J, Aro P, Stroskrubb T, et al. Prevalence of Barrett's esophagus in the general population: an endoscopic study. Gastroenterology 2005;129:1825-1831. (Pubitemid 41772961)
6. van Soest EM, Dieleman JP, Siersema PD, et al. Increasing incidence of Barrett's oesophagus in the general population. Gut 2005;54:1062-1066. (Pubitemid 41025895)
7. Gillen P, Keeling P, Byme PJ, et al. Implication of duodenogastric reflux in the pathogenesis of Barrett's oesophagus. Br J Surg 1988;75: 540-543.
8. Iftikhar SY, Lendrum K, Ledingham S, et al. Bile reflux in columnar lined Barrett's oesophagus. Ann R Coll Surg Engl 1993;75:411-416. (Pubitemid 23323448)
9. Nehra D, Howell P, Williams CP, et al. Toxic bile acids in gastrooesophageal reflux disease: influence of gastric acidity. Gut 1999; 44:598-602. (Pubitemid 29195903)
10. Stein HJ, Feussner H, Kauer W, et al. Alkaline gastroesophageal reflux: assessment by ambulatory esophageal aspiration and pH monitoring. Am J Surg 1994;167:163-168. (Pubitemid 24264159)
11. Phillips RW, Frierson Jr HF, Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol 2003;27: 1442-1447. (Pubitemid 37315196)
12. Moons LM, Bax DA, Kuipers EJ, et al. The homeodomain protein CDX2 is an early marker of Barrett's oesophagus. J Clin Pathol 2004;57: 1063-1068. (Pubitemid 39331357)
13. Kazumori H, Ishihara S, Rumi MA, et al. Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium. Gut 2006;55:16-25. (Pubitemid 41820630)
14. Yang Q, Bermingham NA, Finegold MJ, et al. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 2001;294:2155-2156.
15. Leow CC, Romero MS, Ross S, et al. down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Cancer Res 2004;64:6050-6057. (Pubitemid 39129403)
16. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch Signaling: cell fate control and signal integration in development. Science 1999;284: 770-776. (Pubitemid 29291335)
17. Jensen J, Pedersen EE, Galante P, et al. Control of endodermal endocrine development by Hes-1. Nat Genet 2000;24:36-44. (Pubitemid 30041417)
18. Morrow DJ, Avissar NE, Toia L, et al. Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. Surgery 2009;146:714-722.
19. Menke V, van Es JH, de Lau W, et al. Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by g-secretase inhibition. Dis Model Mech 2010;3:104-110.
20. Mutoh H, Sakamoto H, Hayakawa H, et al. The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. Differentiation 2006;74:313-321. (Pubitemid 43945783)
21. Liu T, Zhang X, So CK, et al. Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. Carcinogenesis 2007;28:488-496. (Pubitemid 46321867)
22. Sampliner RE. Practice guidelines on the diagnosis, surveillance, and therapy of Barrett's esophagus. The Practice Parameter Committee of the American College of Gastroenterology. Am J Gastroenterol 1998;93:1028-1032.
23. Amano Y, Kushiyama Y, Yuki T, et al. Prevalence of and risk factors for Barrett's esophagus with intestinal predominant mucin phenotype. Scand J Gastroenterol 2006;41:873-879. (Pubitemid 43995461)
24. de Both NJ, Wijnhoven BP, Sleddens HF, et al. Establishment of cell lines from adenocarcinomas of the esophagus or gastric cardia growing in vivo and in vitro. Virchows Arch 2001;438:451-456. (Pubitemid 32449052)
25. Hu Y, Williams VA, Gellersen O, et al. The pathogenesis of Barrett's esophagus: secondary bile acids upregulate intestinal differentiation factor CDX2 expression in esophageal cells. J Gastrointest Surg 2007; 11:827-834.
26. Avissar NE, Toia L, Hu Y, et al. Bile acid alone, or in combination with acid, induces CDX2 expression through activation of the epidermal growth factor receptor (EGFR). J Gastrointest Surg 2009; 13:212-222.
27. Debruyne PR, Witek M, Gong L, et al. Bile acids induce ectopic expression of intestinal guanylyl cyclase C through nuclear factorkappa B and Cdx2 in human esophageal cells. Gastroenterology 2006;130:1191-1206.
28. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
29. Dovey HF, John V, Anderson JP, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem 2001;76:173-181. (Pubitemid 32044380)
30. Geling A, Steiner H, Willem M, et al. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep 2002;3:688-694.
31. Ben-Arie N, Bellen HU, Armstrong DL, et al. Math1 is essential for genesis of cerebellar granule neurons. Nature 1997;390:169-172. (Pubitemid 27507985)
32. Bermingham NA, Hassan BA, Price SD, et al. Math1: an essential gene for the generation of inner ear hair cells. Science 1999;284: 1837-1841.
33. Gowan K, Helms AW, Hunsaker TL, et al. Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal intemeurons. Neuron 2001;31:219-232. (Pubitemid 32762976)
34. Leonard JH, Cook AL, Van Gele M, et al. Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. Int J Cancer 2002;101:103-110. (Pubitemid 34970901)
35. Eda A, Osawa H, Satoh K, et al. Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. J Gastroenterol 2003;38:14-22. (Pubitemid 36267690)
36. van Es JH, van Gijn ME, Riccio O, et al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005;435:959-963. (Pubitemid 40896322)
37. Lorenz O, Duluc I, Arcangelis AD, et al. Key role of the cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation. J Cell Biol 1997;139:1553-1565. (Pubitemid 28013675)
38. Park J, Schulz S, Waldman SA. Intestine-specific activity of the human guanylyl cyclase C promoter is regulated by Cdx2. Gastroenterology 2000;119:89-96. (Pubitemid 30452582)
39. Yamamoto H, Bai Y-Q, Yuasa Y. Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun 2003;300:813-818. (Pubitemid 36259834)
40. Mesquita P, Jonckheere N, Almeid R, et al. Human MUC2 mucin gene is transcriptionally regulated by cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem 2003;278: 51549-51556. (Pubitemid 38020398)
41. Alkhoury F, Malo MS, Mozumder M, et al. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. Am J Physiol 2005;289:G285-G289.
42. Ohashi S, Natsuizaka M, Yashiro-Ohtani Y, et al. NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSLdependent transcriptional network. Gastroenterology 2010;139: 2113-2123.
43. Mendelson J, Song S, Li Y, et al. Dysfunctional transforming growth factor-b signaling with constitutively active notch signaling in Barrett's esophageal adenocarcinoma. Cancer 2011;117:3691-3702.