Roles of Krüppel-like factor 4 in oesophageal epithelial cells in Barrett's epithelium development

Gut

Volumn 60, Issue 5, 2011, Pages 608-617

  Kazumori, Hideaki ^a   Ishihara, Shunji ^a   Takahashi, Yoshiko ^a   Amano, Yuji ^b   Kinoshita, Yoshikazu ^a  

^a SHIMANE UNIVERSITY HOSPITAL   (Japan)

^b SHIMANE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MUCIN 2; TRANSCRIPTION FACTOR CDX2; BILE ACID; CDX2 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; KRUPPEL LIKE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARRETT ESOPHAGUS; BINDING SITE; CELL TRANSFORMATION; CELL TYPE; CONTROLLED STUDY; EPITHELIUM CELL; ESOPHAGUS MUCOSA; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CELL; KERATINOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SQUAMOUS CELL METAPLASIA; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; ESOPHAGUS; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; METABOLISM; PHYSIOLOGY;

ANIMALS; BARRETT ESOPHAGUS; BILE ACIDS AND SALTS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; ESOPHAGUS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HOMEOSTASIS; HUMANS; KERATINOCYTES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; RATS; RNA, MESSENGER; TRANSFECTION;

EID: 79953753718     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.221648     Document Type: Article

References (27)

1. Jankowski JA, Harrison RF, Perry I, et al. Barrett's esophagus. Lancet 2000;356:2079-85.
2. Winters C Jr, Spurling TJ, Chobanian SJ, et al. Barrett's esophagus. A prevalent, occult complication of gastroesophageal reflux disease. Gastroenterology 1987;92:118-24.
3. Gillen P, Keeling P, Byrne PJ, et al. Implication of duodenogastric reflux in the pathogenesis of Barrett's oesophagus. Br J Surg 1988;75:540-3.
4. Phillips RW, Frierson HF Jr, Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol 2003;27:1442-7. (Pubitemid 37315196)
5. Moons LMG, Bax DA, Kuipers EJ, et al. The homeodomain protein CDX2 is an early marker of Barrett's oesophagus. J Clin Patol 2004;57:1063-8. (Pubitemid 39331357)
6. Kazumori H, Ishihara S, Rumi MAK, et al. Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium. Gut 2006;55:15-25.
7. Kazumori H, Ishihara S, Kinoshita Y. Roles of caudal-related homeobox gene Cdx1 in oesophageal epithelial cells in Barrett's epithelium development. Gut 2009;58:620-8.
8. McConnell BB, Ghaleb AM, Nandan MO, et al. The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioassays 2007;29:549-57. (Pubitemid 46903942)
9. Shields JM, Christy RJ, Yang VW. Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J Biol Chem 1996;271:20009-17.
10. Ton-That H, Kaestner KH, Shields JM, et al. Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorgenesis. FEBS lett 1997;419:239-43. (Pubitemid 28010818)
11. Katz JP, Perreault N, Goldstein BG, et al. The zinc-finger transcription factor klf4 is required for terminal differentiation of goblet cells in the colon. Development 2002;129:2619-28. (Pubitemid 34874246)
12. Xu J, Lu B, Xu F, et al. Dynamic down-regulation of Krüppel-like factor 4 in colorectal adenoma-carcinoma sequence. J Cancer Res Clin Oncol 2008;134:891-8.
13. Hinoi T, Loda M, Fearon ER. Silencing of cdx2 expression in colon cancer via a dominant repression pathway. J Biol Chem 2003;278:44608-16. (Pubitemid 37377215)
14. Mahatan CS, Kaestner KH, Geiman DE, et al. Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4). Nucleic Acids Res 1999;27:4562-9.
15. Dang DT, Mahatan CS, Dang LH, et al. Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene 2001;20:4884-90. (Pubitemid 32803159)
16. Levrat M, Lambert R, Kirshbaum G. Esophagitis produced by reflux of duodenal contents in rats. Am J Dig Dis 1962;7:564-73.
17. Aslam F, Palumbo L, Augenlicht LH, et al. The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters. Cancer Res 2001;61:570-6. (Pubitemid 32128616)
18. D'Amico M, Wu K, Fu M, et al. The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repess cyclin D1 transcription through distinct cis elements. Cancer Res 2004;64:4122-30. (Pubitemid 38802414)
19. Tatsyta M, Mukaisho K, Sugihara H, et al. Expression of Cdx2 in early GRCL of Barrett's esophagus induced in rats by duodenal reflux. Dig Dis Sci 2005;50:425-31. (Pubitemid 40543726)
20. Pera M, Pera M, de Bolos C, et al. Duodenal-content reflux into the esophasgus leads to expression of Cdx2 and Muc2 in areas of squamous epithelium in rats. Gastrointest Surg 2007;11:869-74.
21. Nehra D, Howell P, Williams CP, et al. Toxic bile acids in gastro-oesophageal reflux disease: influence of gastric acidity. Gut 1999;44:598-602. (Pubitemid 29195903)
22. Wong NA, Wilding J, Bartlett S, et al. CDX1 is an important molecular mediator of Barrett's metaplasia. Proc Natl Acad Sci USA 2005;102:7565-70. (Pubitemid 40741011)
23. Debruyne PR, Witek M, Gong L, et al. Bile acids induce ectopic expression of intestinal guanylyl cyclase C through nuclear factor-κB and Cdx2 in human esophageal cells. Gastroenterology 2006;130:1191-206.
24. Kim S, Domon-Dell C, Wang Q, et al. PTEN and TNF-α regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-κB-dependent pathway. Gastroenterology 2002;123:1163-78.
25. Hormi-Carver K, Zhang X, Zhang HY, et al. Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-κB pathway. Cancer Res 2009;69:672-7.
26. Shie J-L, Chen ZY, Fu M, et al. Gut-enriched Krüppel-like factor represses cycline D1 promoter activity through Sp1 motif. Nucleic Acids Res 2000;28:2969-76. (Pubitemid 30599273)
27. Hinnebusch BF, Siddique A, Henderson JW, et al. Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Krüppel-like factor. Am J Physiol 2004;286:G23-30.