Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity

Diabetologia

Volumn 45, Issue 3, 2002, Pages 369-377

  Summers, L K M ^a   Fielding, B A ^a   Bradshaw, H A ^a   Ilic, V ^a   Beysen, C ^a   Clark, M L ^a   Moore, N R ^b   Frayn, K N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Diet; Insulin sensitivity; Obesity; Polyunsaturated fat; Saturated fat; Subcutaneous fat; Type II diabetes; Visceral fat

Indexed keywords

BIOCHEMICAL MARKER; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID;

ABDOMEN; ADULT; AGED; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET; FAT INTAKE; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS FAT;

ABDOMEN; ADIPOSE TISSUE; BLOOD GLUCOSE; BODY CONSTITUTION; BODY MASS INDEX; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; DIETARY FATS; DIETARY FATS, UNSATURATED; ENERGY METABOLISM; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; MALE; MIDDLE AGED; OBESITY; REFERENCE VALUES; RISK FACTORS;

EID: 0036202677     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-001-0768-3     Document Type: Article

References (50)

1. Usual dietary fat intake and insulin concentrations in healthy women twins
2. Dietary fat content alters insulin-mediated glucose metabolism in healthy men
3. Individual variation in plasma cholesterol response to dietary saturated fat
4. 2-cholesterol and lipoprotein A-1 particle levels by increasing the ratio of polyunsaturated to saturated fatty acids
5. Polyunsaturated fatty acids may impair blood glucose control in type 2 diabetic patients
6. Linoleic-acid-enriched diet: Long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin- dependent diabetic patients
7. Intake of a diet high in trans monoun-saturated fatty acids or saturated fatty acids. Effects on postprandial insulinemia and glycemia in obese patients with NIDDM
8. Substituting dietary saturated for monoun-saturated fat impairs insulin sensitivity in healthy men and women: The KANWU study
9. Dietary fat intake and risk of type 2 diabetes in women
10. Adiposity, fat distribution, and cardiovascular risk
11. Regional adiposity and morbidity
12. Visceral fat accumulation and cardiovascular disease
13. Decrease in intra-abdominal visceral fat may reduce blood pressure in obese hypertensive women
14. Relationships of generalized and regional adiposity to insulin sensitivity in men
15. Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM
16. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
17. Subcutaneous central fat is associated with cardiovascular risk factors in men independently of total fatness and fitness
18. Insulin sensitivity relates to other cardiovascular risk factors in young men: Validation of some modifications of the hyperinsulinaemic, isoglycaemic glucose clamp technique
19. The euglycemic hyperinsulinemic clamp examination: Variability and reproducibility
20. The hyperinsulinaemic-euglycaemic glucose clamp: Reproducibility and metabolic effects of prolonged insulin infusion in healthy subjects
21. In vivo measurement of insulin sensitivity in humans
22. Reduction of visceral adipose tissue and improvement of metabolic indices: Effect of dexfenfluramine in NIDDM
23. Micro-method for measurement of sub-nanomole amounts of triacyl-glycerol
24. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol
25. Postprandial lipemia: The origin of an early peak studied by specific dietary fatty acid intake during sequential meals
26. Body fat assessed from total body density and its estimation from skinfold thickness: Measurements on 481 men and women aged from 16 to 72 years
27. Glucose clamp technique: A method for quantifying insulin secretion and resistance
28. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
29. Fatty acid composition of serum cholesterol esters, and erythrocyte and platelet membranes as indicators of long-term adherence to fat-modified diets
30. Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans
31. Multiple significance tests: The Bonferroni method
32. Biased over- or under-reporting is characteristic of individuals whether over time or by different assessment methods
33. The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters
34. Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging
35. Gender differences in changes in subcutaneous and intra-abdominal fat during weight reduction: An ultrasound study
36. Partial replacement of saturated fatty acids with almonds or walnuts lowers total plasma cholesterol and low-density-lipoprotein cholesterol
37. Fall in total cholesterol concentration over five years in association with changes in fatty acid composition of cooking oil in Mauritius: Cross sectional survey
38. Dietary fat and insulin action in humans
39. Relationship of dietary fat to glucose metabolism
40. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and ω-3 fatty acids in muscle phospholipid
41. Lauric and palmitic acid-enriched diets have minimal impact on serum lipid and lipoprotein concentrations and glucose metabolism in healthy young women
42. No effect of short-term dietary supplementation of saturated and poly- and mono-unsaturated fatty acids on insulin secretion and sensitivity in healthy men
43. A high-stearic acid diet does not impair glucose tolerance and insulin sensitivity in healthy women
44. The relation between insulin sensitivity and the fatty-acid composition of skeletal muscle phospholipids
45. Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men
46. Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides
47. Lipoproteins in atherogenesis
48. Excess abdominal adiposity remains correlated with altered lipid concentrations in healthy older women
49. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance