메뉴 건너뛰기




Volumn 68, Issue , 2014, Pages 936-943

The role of hepcidin in iron metabolism in inflammatory bowel diseases;Rola hepcydyny w metabolizmie zelaza w przebiegu nieswoistych zapaleń jelit

Author keywords

Anaemia; Hepcidin; Inflammatory bowel disease; Iron

Indexed keywords

BIOLOGICAL MARKER; CATION TRANSPORT PROTEIN; HEPCIDIN; IRON; METAL TRANSPORTING PROTEIN 1;

EID: 84920578801     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: 10.5604/17322693.1111365     Document Type: Review
Times cited : (7)

References (60)
  • 1
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated pro-tein involved in intracellular iron metabolism
    • Abboud S., Haile D.J.: A novel mammalian iron-regulated pro-tein involved in intracellular iron metabolism. J. Biol. Chem., 2000; 275: 19906-19912
    • (2000) J. Biol. Chem. , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 2
    • 47649126246 scopus 로고    scopus 로고
    • Forging a field: The golden age of iron biology
    • Andrews N.C.: Forging a field: The golden age of iron biology. Blood, 2008; 112: 219-230
    • (2008) Blood , vol.112 , pp. 219-230
    • Andrews, N.C.1
  • 5
  • 7
    • 34447137331 scopus 로고    scopus 로고
    • Mo-dulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • Babitt J.L., Huang F.W., Xia Y., Sidis Y., Andrews N.C., Lin H.Y.: Mo-dulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J. Clin. Invest., 2007; 117: 1933-1939
    • (2007) J. Clin. Invest. , vol.117 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 11
    • 84872951347 scopus 로고    scopus 로고
    • Hepci-din levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency
    • Bregman D.B., Morris D., Koch T.A., He A.,Goodnough L.T.: Hepci-din levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency. Am. J. Hematol., 2013; 88: 97-101
    • (2013) Am. J. Hematol. , vol.88 , pp. 97-101
    • Bregman, D.B.1    Morris, D.2    Koch, T.A.3    He A.Goodnough, L.T.4
  • 12
    • 33645509481 scopus 로고    scopus 로고
    • Hepcidin inhibits in vitro ery-throid colony formation at reduced erytropoietin concentration
    • Dallalio G., Law E., Means R.T. Jr.: Hepcidin inhibits in vitro ery-throid colony formation at reduced erytropoietin concentration. Blood, 2006; 107: 2702-2704
    • (2006) Blood , vol.107 , pp. 2702-2704
    • Dallalio, G.1    Law, E.2    Means, R.T.3
  • 15
    • 84860574815 scopus 로고    scopus 로고
    • Iron sensing and signaling
    • Evstatiev R., Gasche C.: Iron sensing and signaling. Gut, 2012; 61: 933-952
    • (2012) Gut , vol.61 , pp. 933-952
    • Evstatiev, R.1    Gasche, C.2
  • 16
    • 37449009448 scopus 로고    scopus 로고
    • Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
    • Galy B., Ferring-Appel D., Kaden S., Gröne H.J., Hentze M.W.: Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Me-tab., 2008; 7: 79-85
    • (2008) Cell Me-tab. , vol.7 , pp. 79-85
    • Galy, B.1    Ferring-Appel, D.2    Kaden, S.3    Gröne, H.J.4    Hentze, M.W.5
  • 17
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and me-diator of anemia of inflammation
    • Ganz T.: Hepcidin, a key regulator of iron metabolism and me-diator of anemia of inflammation. Blood, 2003; 102: 783-788
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 18
    • 41549127253 scopus 로고    scopus 로고
    • Iron homeostasis: Fitting the puzzle pieces together
    • Ganz T.: Iron homeostasis: Fitting the puzzle pieces together. Cell Metab., 2008; 7: 288-290
    • (2008) Cell Metab. , vol.7 , pp. 288-290
    • Ganz, T.1
  • 19
    • 33644862202 scopus 로고    scopus 로고
    • Iron imports. IV. Hepcidin and regulation of body iron metabolism
    • Ganz T., Nemeth E.: Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am. J. Physiol. Gastrointest. Liver Physiol., 2006; 290: G199-G203
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290 , pp. G199-G203
    • Ganz, T.1    Nemeth, E.2
  • 21
    • 3242698640 scopus 로고    scopus 로고
    • Iron, anaemia, and in-flammatory bowel diseases
    • Gasche C., Lomer M.C., Cavill I., Weiss G.: Iron, anaemia, and in-flammatory bowel diseases. Gut, 2004; 53: 1190-1197
    • (2004) Gut , vol.53 , pp. 1190-1197
    • Gasche, C.1    Lomer, M.C.2    Cavill, I.3    Weiss, G.4
  • 22
  • 23
    • 65349173063 scopus 로고    scopus 로고
    • Contribution of STAT3 and STAT4 pathways to the regulation of hepcidin by op-posing stimuli
    • Huang H., Constante M., Layoun A., Santos M.M.: Contribution of STAT3 and STAT4 pathways to the regulation of hepcidin by op-posing stimuli. Blood, 2009; 113: 3593-3599
    • (2009) Blood , vol.113 , pp. 3593-3599
    • Huang, H.1    Constante, M.2    Layoun, A.3    Santos, M.M.4
  • 26
    • 84871867139 scopus 로고    scopus 로고
    • Ocena występowania niedokrwi-stos̈ci we wrzodziejacym zapaleniu jelita grubego u dzieci
    • Krzesiek E., Flis A., Iwańczak B.: Ocena występowania niedokrwi-stos̈ci we wrzodziejacym zapaleniu jelita grubego u dzieci. Pol. Merkur. Lekarski, 2012; 33: 138-142
    • (2012) Pol. Merkur. Lekarski , vol.33 , pp. 138-142
    • Krzesiek, E.1    Flis, A.2    Iwańczak, B.3
  • 27
    • 77951086900 scopus 로고    scopus 로고
    • Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis
    • Lee D.H., Zhou L.J., Zhou Z., Xie J.X., Jung J.U., Liu Y., Xi C.X., Mei L., Xiong W.C.: Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood, 2010; 115: 3136-3145
    • (2010) Blood , vol.115 , pp. 3136-3145
    • Lee, D.H.1    Zhou, L.J.2    Zhou, Z.3    Xie, J.X.4    Jung, J.U.5    Liu, Y.6    Xi, C.X.7    Mei, L.8    Xiong, W.C.9
  • 28
    • 70450212843 scopus 로고    scopus 로고
    • Role of matriptase-2 (TMPRSS6) in iron metabolism
    • Lee P.: Role of matriptase-2 (TMPRSS6) in iron metabolism. Acta Haematol., 2009; 122: 87-96
    • (2009) Acta Haematol. , vol.122 , pp. 87-96
    • Lee, P.1
  • 29
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepci-din transcription by interleukin-1 and interleukin-6
    • Lee P., Peng H., Gelbart T., Wang L., Beutler E.: Regulation of hepci-din transcription by interleukin-1 and interleukin-6. Proc. Natl. Acad. Sci. USA, 2005; 102: 1906-1910
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1906-1910
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Wang, L.4    Beutler, E.5
  • 30
    • 5444273169 scopus 로고    scopus 로고
    • Regulacja ogólnoustrojowej homeosta-zy żelaza przez hepcydyne
    • Lipiński P., Starzyński R.R.: Regulacja ogólnoustrojowej homeosta-zy żelaza przez hepcydynę. Postępy Hig. Med. Dos̈w., 2004; 58: 65-73
    • (2004) Postępy Hig. Med. Dos̈w. , vol.58 , pp. 65-73
    • Lipiński, P.1    Starzyński, R.R.2
  • 31
    • 0242521527 scopus 로고    scopus 로고
    • The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression
    • Lymboussaki A., Pignatti E., Montosi G., Garuti C., Haile D.J., Pie-trangelo A.: The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. J. Hepatol., 2003; 39: 710-715
    • (2003) J. Hepatol. , vol.39 , pp. 710-715
    • Lymboussaki, A.1    Pignatti, E.2    Montosi, G.3    Garuti, C.4    Haile, D.J.5    Pie-trangelo, A.6
  • 32
    • 77957304252 scopus 로고    scopus 로고
    • Current status of the measurement of blood hepcidin levels in chronic kidney disease
    • Macdougall I.C., Malyszko J., Hider R.C., Bansal S.S.: Current status of the measurement of blood hepcidin levels in chronic kidney disease. Clin. J. Am. Soc. Nephrol., 2010; 5: 1681-1689
    • (2010) Clin J. Am. Soc. Nephrol. , vol.5 , pp. 1681-1689
    • Macdougall, I.C.1    Malyszko, J.2    Hider, R.C.3    Bansal, S.S.4
  • 33
    • 69249220411 scopus 로고    scopus 로고
    • Hepcidin assays: Ironing out some details
    • Malyszko J.: Hepcidin assays: Ironing out some details. Clin. J. Am. Soc. Nephrol., 2009; 4: 1015-1016
    • (2009) Clin J. Am. Soc. Nephrol. , vol.4 , pp. 1015-1016
    • Malyszko, J.1
  • 34
    • 70450214396 scopus 로고    scopus 로고
    • The role of hepcidin in iron metabolism
    • Nemeth E., Ganz T.: The role of hepcidin in iron metabolism. Acta Haematol., 2009; 122: 78-86
    • (2009) Acta Haematol. , vol.122 , pp. 78-86
    • Nemeth, E.1    Ganz, T.2
  • 35
    • 30144432585 scopus 로고    scopus 로고
    • The N-terminus of hepcidin is essential for its interaction with ferroportin: Structure-function study
    • Nemeth E., Preza G.C., Jung C.L., Kaplan J., Waring A.J., Ganz T.: The N-terminus of hepcidin is essential for its interaction with ferroportin: Structure-function study. Blood, 2006; 107: 328-333
    • (2006) Blood , vol.107 , pp. 328-333
    • Nemeth, E.1    Preza, G.C.2    Jung, C.L.3    Kaplan, J.4    Waring, A.J.5    Ganz, T.6
  • 36
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by bin-ding to ferroportin and inducing its internalization
    • Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., Kaplan J.: Hepcidin regulates cellular iron efflux by bin-ding to ferroportin and inducing its internalization. Science, 2004; 306: 2090-2093
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 37
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., Ganz T.: Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood, 2003; 101: 2461-2463
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 38
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., Vaulont S.: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. USA, 2001; 98: 8780-8785
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6    Vaulont, S.7
  • 40
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for die-tary iron sensing, and its mutation leads to severe iron overload
    • Niederkofler V., Salie R., Arber S.: Hemojuvelin is essential for die-tary iron sensing, and its mutation leads to severe iron overload. J. Clin. Invest., 2005; 115: 2180-2186
    • (2005) J. Clin. Invest. , vol.115 , pp. 2180-2186
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 41
    • 80053130535 scopus 로고    scopus 로고
    • Diagnosing anemia in inflammatory bowel disease: Beyond the established markers
    • Oustamanolakis P., Koutroubakis I.E., Kouroumalis E.A.: Diagnosing anemia in inflammatory bowel disease: Beyond the established markers. J. Crohns Colitis, 2011; 5: 381-391
    • (2011) J. Crohns Colitis , vol.5 , pp. 381-391
    • Oustamanolakis, P.1    Koutroubakis, I.E.2    Kouroumalis, E.A.3
  • 43
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary an-timicrobial peptide synthesized in the liver
    • Park C.H., Valore E.V., Waring A.J., Ganz T.: Hepcidin, a urinary an-timicrobial peptide synthesized in the liver. J. Biol. Chem., 2001; 276: 7806-7810
    • (2001) J. Biol. Chem. , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 46
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homolo-gous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., Loréal O.: A new mouse liver-specific gene, encoding a protein homolo-gous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem., 2001; 276: 7811-7819
    • (2001) J. Biol. Chem. , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loréal, O.7
  • 47
    • 84879455789 scopus 로고    scopus 로고
    • Częstos̈ć występowania niedokrwistos̈ci u dzieci z nowo rozpoznana choroba Les̈niowskiego-Crohna
    • Pytrus T., Flis A., Iwańczak F., Iwańczak B.: Częstos̈ć występowania niedokrwistos̈ci u dzieci z nowo rozpoznana choroba Les̈niowskiego-Crohna. Pol. Merkur. Lekarski, 2013; 34: 263-268
    • (2013) Pol. Merkur. Lekarski , vol.34 , pp. 263-268
    • Pytrus, T.1    Flis, A.2    Iwańczak, F.3    Iwańczak, B.4
  • 49
    • 84877025214 scopus 로고    scopus 로고
    • State of the iron: How to diagnose and efficiently treat iron deficiency anemia in inflammatory bowel disease
    • Reinisch W., Staun M., Bhandari S., Munoz M.: State of the iron: How to diagnose and efficiently treat iron deficiency anemia in inflammatory bowel disease. J. Crohns Colitis, 2013; 7: 429-440
    • (2013) J. Crohns Colitis , vol.7 , pp. 429-440
    • Reinisch, W.1    Staun, M.2    Bhandari, S.3    Munoz, M.4
  • 50
    • 24744458603 scopus 로고    scopus 로고
    • Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
    • Rivera S., Nemeth E., Gabayan V., Lopez M.A., Farshidi D., Ganz T.: Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood, 2005; 106: 2196-2199
    • (2005) Blood , vol.106 , pp. 2196-2199
    • Rivera, S.1    Nemeth, E.2    Gabayan, V.3    Lopez, M.A.4    Farshidi, D.5    Ganz, T.6
  • 52
    • 38349194098 scopus 로고    scopus 로고
    • Furin-mediated release of soluble hemojuvelin: A new link between hypoxia and iron homeosta-sis
    • Silvestri L., Pagani A., Camaschella C.: Furin-mediated release of soluble hemojuvelin: A new link between hypoxia and iron homeosta-sis. Blood, 2008; 111: 924-931
    • (2008) Blood , vol.111 , pp. 924-931
    • Silvestri, L.1    Pagani, A.2    Camaschella, C.3
  • 53
    • 77953278306 scopus 로고    scopus 로고
    • Hepcydyna - hormon uczestniczacy w re-gulacji metabolizmu żelaza w organizmie
    • Sokolowska E., Klimek J.: Hepcydyna - hormon uczestniczacy w re-gulacji metabolizmu żelaza w organizmie. Postępy Biol. Kom., 2007; 34: 15-30
    • (2007) Postępy Biol. Kom. , vol.34 , pp. 15-30
    • Sokolowska, E.1    Klimek, J.2
  • 59
    • 49749092336 scopus 로고    scopus 로고
    • Anemia of chronic disease: A harmful disorder or an adaptive, beneficial response?
    • Zarychanski R., Houston D.S.: Anemia of chronic disease: A harmful disorder or an adaptive, beneficial response? CMAJ, 2008; 179: 333-337
    • (2008) CMAJ , vol.179 , pp. 333-337
    • Zarychanski, R.1    Houston, D.S.2
  • 60
    • 65349126484 scopus 로고    scopus 로고
    • A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression
    • Zhang D.L., Hughes R.M., Ollivierre-Wilson H., Ghosh M.C., Rouault T.A.: A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. Cell Metab., 2009; 9: 461-473
    • (2009) Cell Metab. , vol.9 , pp. 461-473
    • Zhang, D.L.1    Hughes, R.M.2    Ollivierre-Wilson, H.3    Ghosh, M.C.4    Rouault, T.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.