Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes

Cell Metabolism

Volumn 21, Issue 1, 2015, Pages 138-149

  Multhaup, Michael L ^a   Seldin, Marcus M ^a   Jaffe, Andrew E ^b,c   Lei, Xia ^a   Kirchner, Henriette ^d   Mondal, Prosenjit ^a   Li, Yuanyuan ^a   Rodriguez, Varenka ^a   Drong, Alexander ^e   Hussain, Mehboob ^a   Lindgren, Cecilia ^e   McCarthy, Mark ^e,f,g   Näslund, Erik ^h   Zierath, Juleen R ^d   Wong, G William ^a   Feinberg, Andrew P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LIEBER INSTITUTE FOR BRAIN DEVELOPMENT   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g CHURCHILL HOSPITAL   (United Kingdom)

^h DANDERYD HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE; GLUCOSE; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOENOLPYRUVATE CARBOXYKINASE 1; UNCLASSIFIED DRUG; SMALL INTERFERING RNA; TCF7L2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR 7 LIKE 2;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET; DIET INDUCED OBESITY; DNA METHYLATION; DOWN REGULATION; ENHANCER REGION; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE ONTOLOGY; GENE REPLICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GLUCONEOGENESIS; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID ANALYSIS; LIPID DIET; LIPID METABOLISM; LIPODYSTROPHY; LIPOGENESIS; LIVER; LIVER CELL; MACROPHAGE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; PYROSEQUENCING; SUBCUTANEOUS FAT; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC EPIGENESIS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

MUS;

ADIPOCYTES; ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE TOLERANCE TEST; HUMANS; MALE; MICE; MICE, INBRED C57BL; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84920569023     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.12.014     Document Type: Article

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