The STRENGTH AND COOPERATIVITY of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer

Molecular Cell

Volumn 57, Issue 1, 2015, Pages 191-201

  Reshetnyak, Andrey V ^a   Opatowsky, Yarden ^a,b   Boggon, Titus J ^a   Folta Stogniew, Ewa ^a   Tome, Francisco ^a   Lax, Irit ^a   Schlessinger, Joseph ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAR ILAN UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; PROTEIN TYROSINE KINASE; PROTEIN BINDING; RECOMBINANT PROTEIN; STEM CELL FACTOR RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; AUTOPHOSPHORYLATION; CELL TRANSFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; ELECTRON MICROSCOPY; ENZYME ACTIVATION; GAIN OF FUNCTION MUTATION; GASTROINTESTINAL STROMAL TUMOR; HUMAN; HUMAN CELL; IN VITRO STUDY; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; 3T3 CELL LINE; ANIMAL; BACULOVIRIDAE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE; MUTATION; NEOPLASM; PATHOLOGY; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SF9 CELL LINE; SPODOPTERA; X RAY CRYSTALLOGRAPHY;

ANIMALS; BACULOVIRIDAE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; MUTATION; NEOPLASMS; NIH 3T3 CELLS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-KIT; RECOMBINANT PROTEINS; SF9 CELLS; SPODOPTERA;

EID: 84920559004     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.11.021     Document Type: Article

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