Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 5, 2014, Pages 1772-1777

  Opatowsky, Yarden ^a,d   Lax, Irit ^a   Tomé, Francisco ^a   Bleichert, Franziska ^b   Unger, Vinzenz M ^c   Schlessinger, Joseph ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d BAR ILAN UNIVERSITY   (Israel)

Author keywords

Cancer; Cell signaling; Receptor tyrosine kinases; Structural biology; Structure analysis

Indexed keywords

AMINO ACID; DIMER; LIGAND; MONOMER; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; STEM CELL FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; AUTOPHOSPHORYLATION; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPLEX FORMATION; CRYSTAL STRUCTURE; ELECTRON MICROSCOPY; ENZYME PHOSPHORYLATION; GAIN OF FUNCTION MUTATION; GASTROINTESTINAL STROMAL TUMOR; GENE MUTATION; HUMAN; IMAGE RECONSTRUCTION; LIGAND BINDING; MELANOMA; MOLECULAR INTERACTION; ONCOGENE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

CANCER; CELL SIGNALING; RECEPTOR TYROSINE KINASES; STRUCTURAL BIOLOGY; STRUCTURE ANALYSIS;

CRYSTALLOGRAPHY, X-RAY; CYTOPLASM; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-KIT; STEM CELL FACTOR;

EID: 84893474573     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323254111     Document Type: Article

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