The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations

Science Signaling

Volumn 2, Issue 58, 2009, Pages

  Lew, Erin D ^a,b   Furdui, Cristina M ^a,c   Anderson, Karen S ^a   Schlessinger, Joseph ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; TYROSINE; FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR RECEPTOR 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; ENZYME STRUCTURE; GENE DISRUPTION; GENE MUTATION; GLIOBLASTOMA; KINETICS; MOLECULAR MECHANICS; MOLECULE; NONHUMAN; ONCOGENE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; ACCURACY; ANIMAL CELL CULTURE; ANIMAL TISSUE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; SIGNAL TRANSDUCTION; BINDING SITE; GENETICS; METABOLISM; PHOSPHORYLATION;

BINDING SITES; GLIOBLASTOMA; HUMANS; KINETICS; PHOSPHORYLATION; POINT MUTATION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; TYROSINE;

EID: 77953679934     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000021     Document Type: Article

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37. This work was supported by NIH grants RO1-AR051448, RO1-AR051886, and P50-AR054086 to J.S. and NIH grants R21 CA 125284 and R01 CA127580 to K.S.A.