Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases

EMBO Journal

Volumn 26, Issue 3, 2007, Pages 891-901

  Liu, Heli ^a   Chen, Xiaoyan ^a   Focia, Pamela J ^a   He, Xiaolin ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cancer; Growth factor; Protein protein interaction; Signal transduction; X ray crystallography

Indexed keywords

CYTOKINE; EPITOPE; IMMUNOGLOBULIN RECEPTOR; PROTEIN; PROTEIN KIT; PROTEIN TYROSINE KINASE; STEM CELL FACTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; LIGAND BINDING; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; CRYSTALLIZATION; DIMERIZATION; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-KIT; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; STEM CELL FACTOR;

EID: 33846987130     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601545     Document Type: Article

References (52)

1. Barleon B, Totzke F, Herzog C, Blanke S, Kremmer E, Siemeister G, Marme D, Martiny-Baron G (1997) Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1. J Biol Chem 272: 10382-10388
2. Bazan JF (1990) Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87: 6934-6938
3. Ben-Shlomo I, Yu Hsu S, Rauch R, Kowalski HW, Hsueh AJ (2003) Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction. Sci STKE 2003: RE9
4. Besmer P (1991) The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor. Curr Opin Cell Biol 3: 939-946
5. Besmer P, Murphy JE, George PC, Qiu FH, Bergold PJ, Lederman L, Snyder Jr HW, Brodeur D, Zuckerman EE, Hardy WD (1986) A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 320: 415-421
6. Blechman JM, Lev S, Barg J, Eisenstein M, Vaks B, Vogel Z, Givol D, Yarden Y (1995) The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell 80: 103-113
7. Blechman JM, Lev S, Brizzi MF, Leitner O, Pegoraro L, Givol D, Yarden Y (1993) Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor. J Biol Chem 268: 4399-4406
8. Bork P, Holm L, Sander C (1994) The immunoglobulin fold. Structural classification, sequence patterns and common core. J Mol Biol 242: 309-320
9. Brunger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T, Warren GL (1998) Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr D 54: 905-921
10. de Vos AM, Ultsch M, Kossiakoff AA (1992) Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255: 306-312
11. Fichelson S (1998) The FLT3/FLK2 ligand: structure, functions and prospects. Eur Cytokine Netw 9: 7-22
12. Fuh G, Li B, Crowley C, Cunningham B, Wells JA (1998) Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor. J Biol Chem 273: 11197-11204
13. Graddis TJ, Brasel K, Friend D, Srinivasan S, Wee S, Lyman SD, March CJ, McGrew JT (1998) Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen. J Biol Chem 273: 17626-17633
14. Harpaz Y, Chothia C (1994) Many of the immunoglobulin super-family domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. J Mol Biol 238: 528-539
15. Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB (2001) Crystal structure of an Eph receptor-ephrin complex. Nature 414: 933-938
16. Hsu YR, Chang WC, Mendiaz EA, Hara S, Chow DT, Mann MB, Langley KE, Lu HS (1998) Selective deamidation of recombinant human stem cell factor during in vitro aging: isolation and characterization of the aspartyl and isoaspartyl homodimers and heterodimers. Biochemistry 37: 2251-2262
17. Humphrey W, Dalke A, Schulten K (1996) VMD: visual molecular dynamics. J Mol Graph 14: 33-38, 27-38
18. Jiang X, Gurel O, Mendiaz EA, Stearns GW, Clogston CL, Lu HS, Osslund TD, Syed RS, Langley KE, Hendrickson WA (2000) Structure of the active core of human stem cell factor and analysis of binding to its receptor kit. EMBO J 19: 3192-3203
19. Jones TA, Zou JY, Cowan SW, Kjeldgaard M (1991) Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 47: 110-119
20. Kraulis PJ (1991) MOLSCRIPT. J Appl Crystallogr 24: 946-950
21. Krause DS, Van Etten RA (2005) Tyrosine kinases as targets for cancer therapy. N Engl J Med 353: 172-187
22. Langley KE, Mendiaz EA, Liu N, Narhi LO, Zeni L, Parseghian CM, Clogston CL, Leslie I, Pope JA, Lu HS, Zsebo KM, Boone TC (1994) Properties of variant forms of human stem cell factor recombinantly expressed in Escherichia coli. Arch Biochem Biophys 311: 55-61
23. Lemmon MA, Pinchasi D, Zhou M, Lax I, Schlessinger J (1997) Kit receptor dimerization is driven by bivalent binding of stem cell factor. J Biol Chem 272: 6311-6317
24. Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R (2005) Normal and oncogenic forms of the receptor tyrosine kinase kit. Stem Cells 23: 16-43
25. Lev S, Blechman J, Nishikawa S, Givol D, Yarden Y (1993) Interspecies molecular chimeras of kit help define the binding site of the stem cell factor. Mol Cell Biol 13: 2224-2234
26. Lev S, Yarden Y, Givol D (1992) Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor. J Biol Chem 267: 15970-15977
27. Lu HS, Clogston CL, Wypych J, Parker VP, Lee TD, Swiderek K, Baltera Jr RF, Patel AC, Chang DC, Brankow DW, Liu XD, Ogden SG, Karkare SB, Hu SS, Zsebo KM, Langley KE (1992) Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells. Arch Biochem Biophys 298: 150-158
28. Matous JV, Langley K, Kaushansky K (1996) Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclonal antibody. Blood 88: 437-444
29. Mendiaz EA, Chang DG, Boone TC, Grant JR, Wypych J, Aguero B, Egrie JC, Langley KE (1996) Epitope mapping and immunoneutralization of recombinant human stem-cell factor. Eur J Biochem 239: 842-849
30. Mohammadi M, Olsen SK, Ibrahimi OA (2005) Structural basis for fibroblast growth factor receptor activation. Cytokine Growth Factor Rev 16: 107-137
31. Nicholls A, Sharp KA, Honig B (1991) Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11: 281-296
32. Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M (1992) Crystal structure of human platelet-derived growth factor BB. EMBO J 11: 3921-3926
33. Otwinowski Z, Minor W (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276: 307-326
34. Pandit J, Bohm A, Jancarik J, Halenbeck R, Koths K, Kim SH (1992) Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. Science 258: 1358-1362
35. Philo JS, Wen J, Wypych J, Schwartz MG, Mendiaz EA, Langley KE (1996) Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit. J Biol Chem 271: 6895-6902
36. Reilly JT (2003) Receptor tyrosine kinases in normal and malignant haematopoiesis. Blood Rev 17: 241-248
37. Sasaki T, Knyazev PG, Clout NJ, Cheburkin Y, Gohring W, Ullrich A, Timpl R, Hohenester E (2006) Structural basis for Gas6-Axl signalling. EMBO J 25: 80-87
38. Savvides SN, Boone T, Andrew Karplus P (2000) Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. Nat Struct Biol 7: 486-491
39. Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103: 211-225
40. Schlessinger J (2002) Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110: 669-672
41. Sprang SR, Bazan JF (1993) Cytokine structural taxonomy and mechanisms of receptor engagement. Curr Opin Struct Biol 3: 815-827
42. Stroud RM, Wells JA (2004) Mechanistic diversity of cytokine receptor signaling across cell membranes. Sci STKE 2004: re7
43. Sun L, Hui AM, Su Q, Vortmeyer A, Kotliarov Y, Pastorino S, Passaniti A, Menon J, Walling J, Bailey R, Rosenblum M, Mikkelsen T, Fine HA (2006) Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 9: 287-300
44. Tallquist M, Kazlauskas A (2004) PDGF signaling in cells and mice. Cytokine Growth Factor Rev 15: 205-213
45. Taylor EW, Fear AL, Bohm A, Kim SH, Koths K (1994) Structure-function studies on recombinant human macrophage colonystimulating factor (M-CSF). J Biol Chem 269: 31171-31177
46. Terwilliger TC, Berendzen J (1999) Automated structure solution for MIR and MAD. Acta Crystallogr D 55: 849-861
47. Wang X, Rickert M, Garcia KC (2005) Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science 310: 1159-1163
48. Wang ZE, Myles GM, Brandt CS, Lioubin MN, Rohrschneider L (1993) Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain. Mol Cell Biol 13: 5348-5359
49. Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM (1997) Crystal structure at 1.7 Åresolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell 91: 695-704
50. Wiesmann C, Ultsch MH, Bass SH, de Vos AM (1999) Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature 401: 184-188
51. Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6: 3341-3351
52. Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP (2000) Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation. Proc Natl Acad Sci USA 97: 7732-7737