Treatment of IL-21R-Fc control autoimmune arthritis via suppression of STAT3 signal pathway mediated regulation of the Th17/Treg balance and plasma B cells

Immunology Letters

Volumn 163, Issue 2, 2015, Pages 143-150

  Ryu, Jun Geol ^a   Lee, Jennifer ^a   Kim, Eun Kyung ^a   Seo, Hyeon Beom ^a   Park, Jin Sil ^a   Lee, Seon Yeong ^a   Moon, Young Mee ^a   Yoo, Seok Ho ^b   Park, Young woo ^b   Park, Sung Hwan ^a   Cho, Mi La ^a   Kim, Ho Youn ^c  

^a The Catholic University of Korea   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Konkuk University   (South Korea)

Author keywords

Autoimmune arthritis; IL 21R Fc; Plasma cell; STAT3; Th17

Indexed keywords

ANTIRHEUMATIC AGENT; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CD4 ANTIGEN; IMMUNOGLOBULIN; INTERLEUKIN 21; MESSENGER RNA; RECOMBINANT INTERLEUKIN 21 RECEPTOR FUSION PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; HYBRID PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN DERIVATIVE; PRDM1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MECHANISM; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN CELL; TH17 CELL; ANIMAL; ARTHRITIS, EXPERIMENTAL; CD4+ T LYMPHOCYTE; CONFOCAL MICROSCOPY; CYTOLOGY; DBA MOUSE; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PHOSPHORYLATION; PLASMA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; WESTERN BLOTTING;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNOGLOBULIN G; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-17; INTERLEUKINS; MALE; MICE, INBRED DBA; MICROSCOPY, CONFOCAL; PHOSPHORYLATION; PLASMA CELLS; RECEPTORS, INTERLEUKIN-21; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSCRIPTION FACTORS;

EID: 84920422407     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2014.09.007     Document Type: Article

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