Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 1, 2016, Pages 71-78

  Zhang, Donghong ^a,c   Sun, Xiaoli ^a   Liu, Jianlan ^c   Xie, Xina ^c   Cui, Wei ^b,c   Zhu, Yi ^d  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^d TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Aging; endothelial cells; homocysteine; human; telomerase reverse transcriptase

Indexed keywords

ANGIOTENSIN II; DNA METHYLTRANSFERASE 1; FOLIC ACID; HOMOCYSTEINE; PROTEIN P16; PROTEIN P21; PROTEIN P53; S ADENOSYLMETHIONINE; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR CTCF; CCCTC-BINDING FACTOR; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; REPRESSOR PROTEIN; TELOMERASE; TERT PROTEIN, HUMAN; TERT PROTEIN, MOUSE; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA INTIMA; BINDING SITE; CARDIOVASCULAR DISEASE; CELL AGING; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA METHYLATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; EPIGENETICS; GEL MOBILITY SHIFT ASSAY; HYPERHOMOCYSTEINEMIA; IN VIVO STUDY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; TELOMERE; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; MALE; METABOLISM; PROMOTER REGION; RNA INTERFERENCE; TELOMERE SHORTENING; TIME;

ANGIOTENSIN II; ANIMALS; BINDING SITES; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE MODELS, ANIMAL; DNA METHYLATION; FOLIC ACID; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMOCYSTEINE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; RNA INTERFERENCE; S-ADENOSYLMETHIONINE; SP1 TRANSCRIPTION FACTOR; TELOMERASE; TELOMERE; TELOMERE SHORTENING; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84920267233     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.303899     Document Type: Review

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