Effects of selaginellin on homocysteine-induced senescence in human umbilical vein endothelial cells

Journal of Cardiovascular Pharmacology

Volumn 55, Issue 6, 2010, Pages 560-566

  Wang, Chen Jing ^a   Hu, Chang Ping ^a   Xu, Kang Ping ^a   Tan, Gui Shan ^a   Li, Yuan Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

homocysteine; human umbilical vein endothelial cell; oxidative stress; reactive oxygen species; selaginellin; sirt1

Indexed keywords

ALPHA TOCOPHEROL; BETA GALACTOSIDASE; HOMOCYSTEINE; PLANT EXTRACT; PROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; SELAGINELLIN; SIRTUIN 1; TELOMERASE; UNCLASSIFIED DRUG; ANTIOXIDANT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN;

ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; BIOLOGICAL ACTIVITY; CELL PROTECTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SELAGINELLA; SELAGINELLA PULVINATA; SENESCENCE; SIRT1 GENE; UMBILICAL VEIN; AGING; CELL AGING; CELL CYCLE; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; ENDOTHELIUM; METABOLISM; PHYSIOLOGY; UPREGULATION;

AGING; ANTIOXIDANTS; BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIUM; HOMOCYSTEINE; HUMANS; NITRIC OXIDE SYNTHASE TYPE III; REACTIVE OXYGEN SPECIES; UMBILICAL VEINS; UP-REGULATION;

EID: 77953808161     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181d9f478     Document Type: Article

References (34)

1. Moselhy SS, Demerdash SH. Plasma homocysteine and oxidative stress in cardiovascular disease. Dis Markers. 2003;19:27-31.
2. Jin L, Caldwell RB, Li-Masters T, et al. Homocysteine induces endothelial dysfunction via inhibition of arginine transport. J Physiol Pharmacol. 2007;58:191-206.
3. Preda I, Bencze J, Vargova K. Endothelial function and ischemic heart disease. Orv Hetil. 2005;146(20 Suppl 2):1047-1053.
4. Coppola A, Davi G, De Stefano V, et al. Homocysteine, coagulation, platelet function, and thrombosis. Semin Thromb Hemost. 2000;26:243-254.
5. Ronco AM, Garrido A, Llanos MN, et al. Effect of homocysteine, folates, and cobalamin on endothelial cell- and copper-induced LDL oxidation. Lipids. 2005;40:259-264.
6. Papatheodorou L, Weiss N. Vascular oxidant stress and inflammation in hyperhomocysteinemia. Antioxid Redox Signal. 2007;9:1941-1958.
7. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res. 2005;66:286-294.
8. Muller-Werdan U, Meisel M, Schirdewahn P, et al. Elderly patients with cardiovascular diseases. Internist (Berl). 2007;48:1211-1219.
9. Minamino T, Miyauchi H, Yoshida T, et al. Endothelial cell senescence in human atherosclerosis: role of telomeres in endothelial dysfunction. J Cardiol. 2003;41:39-40.
10. Kang LS, Reyes RA, Muller-Delp JM. Aging impairs flow-induced dilation in coronary arterioles: role of NO and H(2)O(2). Am J Physiol Heart Circ Physiol. 2009;297:H1087-H1095.
11. Modrick ML, Didion SP, Sigmund CD, et al. Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ Physiol. 2009;296:H1914-H1919.
12. Scalera F, Martens-Lobenhoffer J, Tager M, et al. Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging. Biochem Biophys Res Commun. 2006;345:1075-1082.
13. Xu D, Neville R, Finkel T. Homocysteine accelerates endothelial cell senescence. FEBS Lett. 2000;470:20-24.
14. Sah NK, Singh SN, Sahdev S, et al. Indian herb "Sanjeevani" (Selaginella bryopteris) can promote growth and protect against heat shock and apoptotic activities of ultra violet and oxidative stress. J Biosci. 2005;30: 499-505.
15. Chen K, Plumb GW, Bennett RN, et al. Antioxidant activities of extracts from five anti-viral medicinal plants. J Ethnopharmacol. 2005;96:201-205.
16. Wang CJ, Hu CP, Xu KP, et al. Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells. Naunyn Schmiedebergs. Arch Pharmacol. 2010;381:73-81.
17. Ota H, Eto M, Ako J, et al. Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation. J Am Coll Cardiol. 2009;53:2298-2305.
18. Nakano E, Taiwo FA, Nugent D, et al. Downstream effects on human low density lipoprotein of homocysteine exported from endothelial cells in an in vitro system. J Lipid Res. 2005;46:484-493.
19. Okatani Y, Wakatsuki A, Reiter RJ. Protective effect of melatonin against homocysteine-induced vasoconstriction of human umbilical artery. Biochem Biophys Res Commun. 2000;277:470-475.
20. Smith JR, Pereira-Smith OM. Replicative senescence: implications for in vivo aging and tumor suppression. Science. 1996;273:63-67.
21. Minamino T, Miyauchi H, Yoshida T, et al. The role of vascular cell senescence in atherosclerosis: antisenescence as a novel therapeutic strategy for vascular aging. Curr Vasc Pharmacol. 2004;2:141-148.
22. Hayashi T, Iguchi A. Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers. Geriatr Gerontol Int. January 19, 2010. [Epub ahead of print].
23. Minamino T, Komuro I. Antisenescence as a novel therapeutic strategy for vascular aging. Nippon Ronen Igakkai Zasshi. 2006;43:347-350.
24. Blackwell KA, Sorenson JP, Richardson DM, et al. Mechanisms of aginginduced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin. Am J Physiol Heart Circ Physiol. 2004;287: H2448-H2453.
25. Huang HW, Guo MH, Lin RJ, et al. Hyperhomocysteinemia is a risk factor of middle cerebral artery stenosis. J Neurol. 2007;254:364-367.
26. Signorello MG, Segantin A, Passalacqua M, et al. Homocysteine decreases platelet NO level via protein kinase C activation. Nitric Oxide. 2009;20:104-113.
27. Siow YL, Au-Yeung KK, Woo CW, et al. Homocysteine stimulates phosphorylation of NADPH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cbeta activation. Biochem J. 2006;398: 73-82.
28. Okatani Y,Wakatsuki A, Reiter RJ. Melatonin counteracts potentiation by homocysteine of KCL-induced vasoconstriction in human umbilical artery: relation to calcium influx. Biochem Biophys Res Commun. 2001; 280:940-944.
29. Huang RF, Huang SM, Lin BS, et al. N-Acetylcysteine, vitamin C and vitamin E diminish homocysteine thiolactone-induced apoptosis in human promyeloid HL-60 cells. J Nutr. 2002;132:2151-2156.
30. Nappo F, De Rosa N, Marfella R, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA. 1999;281:2113-2118.
31. Chambers JC, McGregor A, Jean-Marie J, et al. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation. 1999;99:1156-1160.
32. Ota H, Akishita M, Eto M, et al. Sirt1 modulates premature senescencelike phenotype in human endothelial cells. J Mol Cell Cardiol. 2007;43: 571-579.
33. Vijg J, Maslov AY, Suh Y. Aging: a sirtuin shake-up? Cell. 2008;135: 797-798.
34. Chua KF, Mostoslavsky R, Lombard DB, et al. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab. 2005;2:67-76.