Antitumor and antimetastatic actions of dihydroxycoumarins (esculetin or fraxetin) through the inhibition of M2 macrophage differentiation in tumor-associated macrophages and/or G1 arrest in tumor cells

European Journal of Pharmacology

Volumn 746, Issue , 2015, Pages 115-125

  Kimura, Yoshiyuki ^a   Sumiyoshi, Maho ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antimetastatic; Antitumor; Dihydroxycoumarins; G1 arrest; M2 macrophage; Stat 3 phosphorylation

Indexed keywords

COUMARIN DERIVATIVE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; DAPHNETIN; ESCULETIN; FRAXETIN; INTERLEUKIN 10; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTINEOPLASTIC AGENT; CCL2 PROTEIN, HUMAN; GELATINASE A; MONOCYTE CHEMOTACTIC PROTEIN 1; PHORBOL 13 ACETATE 12 MYRISTATE; UMBELLIFERONE DERIVATIVE; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER GROWTH; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LIVER METASTASIS; LUNG METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; OSTEOSARCOMA CELL LINE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL; TUMOR MICROENVIRONMENT; ANIMAL; APOPTOSIS; BIOSYNTHESIS; BODY WEIGHT; CELL POLARITY; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLISM; METASTASIS; OSTEOSARCOMA; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BODY WEIGHT; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL POLARITY; CELL PROLIFERATION; CHEMOKINE CCL2; COUMARINS; CYCLIN-DEPENDENT KINASE 4; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-10; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 2; MICE; NEOPLASM METASTASIS; OSTEOSARCOMA; STAT3 TRANSCRIPTION FACTOR; TETRADECANOYLPHORBOL ACETATE; TRANSFORMING GROWTH FACTOR BETA1; UMBELLIFERONES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84920126518     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.10.048     Document Type: Article

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