-
1
-
-
0038166888
-
Antitumor and antimetastatic activities of Angelica keiskei roots. Part 1: Isolation of an active substance, xanthoangelol
-
Kimura Y., and Baba K. Antitumor and antimetastatic activities of Angelica keiskei roots. Part 1: Isolation of an active substance, xanthoangelol. Int. J. Cancer 106 (2003) 429-437
-
(2003)
Int. J. Cancer
, vol.106
, pp. 429-437
-
-
Kimura, Y.1
Baba, K.2
-
2
-
-
1842536365
-
Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots
-
Kimura Y., Taniguchi M., and Baba K. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Planta Med. 70 (2004) 211-219
-
(2004)
Planta Med.
, vol.70
, pp. 211-219
-
-
Kimura, Y.1
Taniguchi, M.2
Baba, K.3
-
3
-
-
32944463899
-
Angiogenesis
-
Folkman J. Angiogenesis. Annu. Rev. Med. 57 (2006) 1-18
-
(2006)
Annu. Rev. Med.
, vol.57
, pp. 1-18
-
-
Folkman, J.1
-
4
-
-
33344472286
-
Antiangiogenesis in cancer therapy - endostatin and its mechanisms of action
-
Folkman J. Antiangiogenesis in cancer therapy - endostatin and its mechanisms of action. Exp. Cell Res. 312 (2006) 594-607
-
(2006)
Exp. Cell Res.
, vol.312
, pp. 594-607
-
-
Folkman, J.1
-
5
-
-
33846018408
-
Is angiogenesis an organizing principle in biology and medicine?
-
Folkman J. Is angiogenesis an organizing principle in biology and medicine?. J. Pediatr. Surg. 42 (2006) 1-11
-
(2006)
J. Pediatr. Surg.
, vol.42
, pp. 1-11
-
-
Folkman, J.1
-
6
-
-
0029790466
-
The second immunoglobulin-like domain of the VEFG tyrosine kinase receptor initiate a signal transduction cascade
-
Davis-Smyth T., Chen H., Park J., Presta L.G., and Ferrara N. The second immunoglobulin-like domain of the VEFG tyrosine kinase receptor initiate a signal transduction cascade. EMBO J. 15 (1996) 4919-4927
-
(1996)
EMBO J.
, vol.15
, pp. 4919-4927
-
-
Davis-Smyth, T.1
Chen, H.2
Park, J.3
Presta, L.G.4
Ferrara, N.5
-
7
-
-
0032720628
-
Vascular endothelial growth effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent
-
Bernatchez P.N., Soker S., and Sirois M.G. Vascular endothelial growth effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. J. Biol. Chem. 274 (1999) 31047-31054
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31047-31054
-
-
Bernatchez, P.N.1
Soker, S.2
Sirois, M.G.3
-
8
-
-
0034000699
-
VEGF receptor signaling in tumor angiogenesis
-
McMahon G. VEGF receptor signaling in tumor angiogenesis. Oncologist 5 (2000) 3-10
-
(2000)
Oncologist
, vol.5
, pp. 3-10
-
-
McMahon, G.1
-
9
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N., Gerber H.P., and Lecouter J. The biology of VEGF and its receptors. Nat. Med. 9 (2003) 669-676
-
(2003)
Nat. Med.
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
Lecouter, J.3
-
10
-
-
0033556287
-
A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signaling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases
-
Meyer M., Clauss M., Lepple-Wienhues A., Waltenberger J., Augustin H.G., Ziche M., Lanz C., Büttner M., Rziha H.-J., and Dehio C. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signaling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J. 18 (1999) 363-374
-
(1999)
EMBO J.
, vol.18
, pp. 363-374
-
-
Meyer, M.1
Clauss, M.2
Lepple-Wienhues, A.3
Waltenberger, J.4
Augustin, H.G.5
Ziche, M.6
Lanz, C.7
Büttner, M.8
Rziha, H.-J.9
Dehio, C.10
-
11
-
-
0034693879
-
Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis
-
Karkkainen M.J., and Petrova T.V. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis. Oncogene 19 (2000) 5598-5605
-
(2000)
Oncogene
, vol.19
, pp. 5598-5605
-
-
Karkkainen, M.J.1
Petrova, T.V.2
-
12
-
-
0027407938
-
Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon γ
-
Hock H., Dorsch M., Kunzenforf Y., Quin Z., Diamanstein T., and Lanskenstein T. Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon γ. Proc. Natl. Acad. Sci. USA 90 (1993) 2774-2778
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 2774-2778
-
-
Hock, H.1
Dorsch, M.2
Kunzenforf, Y.3
Quin, Z.4
Diamanstein, T.5
Lanskenstein, T.6
-
15
-
-
0028052808
-
Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?
-
Colomno H.P., and Forni G. Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?. Immunol. Today 15 (1994) 48-51
-
(1994)
Immunol. Today
, vol.15
, pp. 48-51
-
-
Colomno, H.P.1
Forni, G.2
-
16
-
-
0038784488
-
IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perfolin but are independent of IFN-γ
-
Ma H.-L., Whiters M.J., Konz R.F., Senices M., Young D.A., Grusby M.J., Collins M., and Dunussi-Joannopoulos K. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perfolin but are independent of IFN-γ. J. Immunol. 171 (2003) 608-615
-
(2003)
J. Immunol.
, vol.171
, pp. 608-615
-
-
Ma, H.-L.1
Whiters, M.J.2
Konz, R.F.3
Senices, M.4
Young, D.A.5
Grusby, M.J.6
Collins, M.7
Dunussi-Joannopoulos, K.8
-
17
-
-
0033028757
-
Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice
-
Iigo M., Kuhara T., Ushida Y., Sekine K., Moore M.A., and Tsuda H. Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice. Clin. Exp. Metastasis 17 (1999) 35-40
-
(1999)
Clin. Exp. Metastasis
, vol.17
, pp. 35-40
-
-
Iigo, M.1
Kuhara, T.2
Ushida, Y.3
Sekine, K.4
Moore, M.A.5
Tsuda, H.6
-
18
-
-
0033767482
-
Activation of intestinal mucosal immunity in tumor bearing mice by lactoferrin
-
Wang W.-P., Iigo M., Sato J., Seike K., Adachi I., and Tsuda H. Activation of intestinal mucosal immunity in tumor bearing mice by lactoferrin. Jpn. J. Cancer Res. 91 (2000) 1022-1027
-
(2000)
Jpn. J. Cancer Res.
, vol.91
, pp. 1022-1027
-
-
Wang, W.-P.1
Iigo, M.2
Sato, J.3
Seike, K.4
Adachi, I.5
Tsuda, H.6
-
19
-
-
1842582833
-
Antitumor effects of various low-molecular-weight chitosans are due to increased natural killer activity of intestinal intraepithelial lymphocytes in sarcoma 180-bearing mice
-
Maeda Y., and Kimura Y. Antitumor effects of various low-molecular-weight chitosans are due to increased natural killer activity of intestinal intraepithelial lymphocytes in sarcoma 180-bearing mice. J. Nutr. 134 (2004) 945-950
-
(2004)
J. Nutr.
, vol.134
, pp. 945-950
-
-
Maeda, Y.1
Kimura, Y.2
-
20
-
-
85004245225
-
Chemical studies of Angelica japonica A. Gary. I. On the constituents of the ethyl acetate extract of the root
-
Baba K., Hata K., Kimura Y., Matsuyama Y., and Kozawa M. Chemical studies of Angelica japonica A. Gary. I. On the constituents of the ethyl acetate extract of the root. Chem. Pharm. Bull. 29 (1981) 2565-2570
-
(1981)
Chem. Pharm. Bull.
, vol.29
, pp. 2565-2570
-
-
Baba, K.1
Hata, K.2
Kimura, Y.3
Matsuyama, Y.4
Kozawa, M.5
-
21
-
-
0034991938
-
Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice
-
Kimura Y., and Okuda H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J. Nutr. 131 (2001) 1844-1849
-
(2001)
J. Nutr.
, vol.131
, pp. 1844-1849
-
-
Kimura, Y.1
Okuda, H.2
-
22
-
-
23844503982
-
Antitumor and antimetastatic actions of eicosapentaenoic acid ethylester and its by-products formed during accelerated stability testing
-
Kimura Y., and Sumiyoshi M. Antitumor and antimetastatic actions of eicosapentaenoic acid ethylester and its by-products formed during accelerated stability testing. Cancer Sci. 96 (2005) 441-450
-
(2005)
Cancer Sci.
, vol.96
, pp. 441-450
-
-
Kimura, Y.1
Sumiyoshi, M.2
-
23
-
-
5044220447
-
Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions
-
Kimura Y., Kido T., Takaku T., Sumiyoshi M., and Baba K. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci. 95 (2004) 758-764
-
(2004)
Cancer Sci.
, vol.95
, pp. 758-764
-
-
Kimura, Y.1
Kido, T.2
Takaku, T.3
Sumiyoshi, M.4
Baba, K.5
-
24
-
-
0033866668
-
Shear stress enhances human endothelial cell wound closure in vitro
-
Albuquerque M.L.C., Waters C.M., Salvia U., Schnaper H.W., and Flozak A. Shear stress enhances human endothelial cell wound closure in vitro. Am. J. Physiol. Heart. Circ. Physiol. 279 (2000) H293-H302
-
(2000)
Am. J. Physiol. Heart. Circ. Physiol.
, vol.279
-
-
Albuquerque, M.L.C.1
Waters, C.M.2
Salvia, U.3
Schnaper, H.W.4
Flozak, A.5
-
25
-
-
0033761518
-
Effects of naturally occurring stilbene glucosides from medicinal plants and wine, on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice
-
Kimura Y., and Okuda H. Effects of naturally occurring stilbene glucosides from medicinal plants and wine, on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice. J. Pharm. Pharmacol. 12 (2000) 1287-1295
-
(2000)
J. Pharm. Pharmacol.
, vol.12
, pp. 1287-1295
-
-
Kimura, Y.1
Okuda, H.2
-
26
-
-
0036303726
-
Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice
-
Kimura Y. Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. J. Nutr. 132 (2002) 2069-2075
-
(2002)
J. Nutr.
, vol.132
, pp. 2069-2075
-
-
Kimura, Y.1
-
28
-
-
0026629718
-
Effects of inflammatory cytokines on hypoxia-induced erythropoietin production
-
Faquin W.C., Schneider J.J., and Goldberg M.A. Effects of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 79 (1992) 1987-1994
-
(1992)
Blood
, vol.79
, pp. 1987-1994
-
-
Faquin, W.C.1
Schneider, J.J.2
Goldberg, M.A.3
-
29
-
-
1842416574
-
Oxygene(es) and the hypoxia-inducible factor-1
-
Wagner R.H., and Gassmann M. Oxygene(es) and the hypoxia-inducible factor-1. J. Biol. Chem. 378 (1997) 609-616
-
(1997)
J. Biol. Chem.
, vol.378
, pp. 609-616
-
-
Wagner, R.H.1
Gassmann, M.2
-
30
-
-
0033181324
-
Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1
-
Hellwig-Bügel T., Rutkowski K., Metzen E., Fandrey J., and Jelkmann W. Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1. Blood 94 (1999) 1561-1567
-
(1999)
Blood
, vol.94
, pp. 1561-1567
-
-
Hellwig-Bügel, T.1
Rutkowski, K.2
Metzen, E.3
Fandrey, J.4
Jelkmann, W.5
-
31
-
-
0034663561
-
Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synoviol fibroblasts
-
Thronton R.C., Land D., Borghaei R.C., Pease E.A., Caro J., and Mochan E. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synoviol fibroblasts. Biochem. J. 350 (2000) 307-312
-
(2000)
Biochem. J.
, vol.350
, pp. 307-312
-
-
Thronton, R.C.1
Land, D.2
Borghaei, R.C.3
Pease, E.A.4
Caro, J.5
Mochan, E.6
-
32
-
-
0023157363
-
Angiogenic factors
-
Folkman J., and Klagsbrun M. Angiogenic factors. Science 235 (1987) 442-447
-
(1987)
Science
, vol.235
, pp. 442-447
-
-
Folkman, J.1
Klagsbrun, M.2
-
35
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung D.W., Cachianes G., Kuang W.J., Goefel D.V., and Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989) 1306-1309
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
Goefel, D.V.4
Ferrara, N.5
-
36
-
-
0027368830
-
Role of natural killer cells in cancer
-
Pross H.F., and Lotzova E. Role of natural killer cells in cancer. Nat. Immun. 12 (1993) 279-292
-
(1993)
Nat. Immun.
, vol.12
, pp. 279-292
-
-
Pross, H.F.1
Lotzova, E.2
-
37
-
-
0028812719
-
The role of natural killer cells in immune surveillance of cancer
-
Whiteside T.L., and Herberman R.B. The role of natural killer cells in immune surveillance of cancer. Curr. Opin. Immunol 7 (1995) 704-710
-
(1995)
Curr. Opin. Immunol
, vol.7
, pp. 704-710
-
-
Whiteside, T.L.1
Herberman, R.B.2
-
38
-
-
0032031429
-
Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy
-
Lode H.N., Xiang R., Dreier T., Varki N.M., Gillies S.D., and Reisfedl R.A. Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy. Blood 91 (1998) 1706-1715
-
(1998)
Blood
, vol.91
, pp. 1706-1715
-
-
Lode, H.N.1
Xiang, R.2
Dreier, T.3
Varki, N.M.4
Gillies, S.D.5
Reisfedl, R.A.6
-
39
-
-
0027239503
-
Antitumor and antimetastatic activity of interleukin 12 against murine tumors
-
Brunda M., Luistro L., Warrier R.R., Wright R.B., Hunnard B.R., Murphy M., Wolf S.F., and Gately M.K. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178 (1993) 1223-1230
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1223-1230
-
-
Brunda, M.1
Luistro, L.2
Warrier, R.R.3
Wright, R.B.4
Hunnard, B.R.5
Murphy, M.6
Wolf, S.F.7
Gately, M.K.8
-
40
-
-
0031937388
-
Proinflammatory and immunoregulatory function of interleukin-2
-
Trinchieri G. Proinflammatory and immunoregulatory function of interleukin-2. Int. Rev. Immunol. 16 (1998) 365-396
-
(1998)
Int. Rev. Immunol.
, vol.16
, pp. 365-396
-
-
Trinchieri, G.1
-
41
-
-
0025804998
-
Role of natural killer and T-cells in interferon induced inhibition of spontaneous metastases of the B16F10L murine melanoma
-
Markovic S.N., and Murasko D.M. Role of natural killer and T-cells in interferon induced inhibition of spontaneous metastases of the B16F10L murine melanoma. Cancer Res. 51 (1991) 1124-1128
-
(1991)
Cancer Res.
, vol.51
, pp. 1124-1128
-
-
Markovic, S.N.1
Murasko, D.M.2
-
42
-
-
0030719401
-
Antitumor effects of the combination immunotherapy with interleukin-12 and tumor necrosis factor α in mice
-
Lasek W., Feleszko W., Golab J., Stoklosa T., Marczak M., Dabrowska A., Malejczyk M., and Jakobisiak M. Antitumor effects of the combination immunotherapy with interleukin-12 and tumor necrosis factor α in mice. Cancer Immunol. Immunother 45 (1997) 100-108
-
(1997)
Cancer Immunol. Immunother
, vol.45
, pp. 100-108
-
-
Lasek, W.1
Feleszko, W.2
Golab, J.3
Stoklosa, T.4
Marczak, M.5
Dabrowska, A.6
Malejczyk, M.7
Jakobisiak, M.8
-
43
-
-
20144370978
-
AZD2171: highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
-
Wedge S.R., Kendrew J., Hennequin L.F., Valentine P.J., Barry S.T., Brave S.R., Smith N.R., James N.H., Dukes M., Vurwen J.O., Chester R., Jackson J.A., Voffey S.J., Kilburn L.L., Barnett S., Richmond G.HP., Wafsworth P.F., Walker M., Bigley A.L., Taylor S.T., Cooper L., Beck S., Jürgensmeier J.M., and Ogilivie D.J. AZD2171: highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 65 (2005) 4389-4400
-
(2005)
Cancer Res.
, vol.65
, pp. 4389-4400
-
-
Wedge, S.R.1
Kendrew, J.2
Hennequin, L.F.3
Valentine, P.J.4
Barry, S.T.5
Brave, S.R.6
Smith, N.R.7
James, N.H.8
Dukes, M.9
Vurwen, J.O.10
Chester, R.11
Jackson, J.A.12
Voffey, S.J.13
Kilburn, L.L.14
Barnett, S.15
Richmond, G.HP.16
Wafsworth, P.F.17
Walker, M.18
Bigley, A.L.19
Taylor, S.T.20
Cooper, L.21
Beck, S.22
Jürgensmeier, J.M.23
Ogilivie, D.J.24
more..
-
44
-
-
8944248812
-
Flk-1 as a target for tumor growth inhibition
-
Strawn L.M., McMahon G., App H., Schreck R., Kuchler W.R., Longhi M.P., Hui H.T.H., Tang C., Levitzki A., Gazit A., Chen I., Keri G., Orfi L., Risau W., Flamme I., Ullrich A., Hirthe K.P., and Shawver L.K. Flk-1 as a target for tumor growth inhibition. Cancer Res. 56 (1996) 3540-3545
-
(1996)
Cancer Res.
, vol.56
, pp. 3540-3545
-
-
Strawn, L.M.1
McMahon, G.2
App, H.3
Schreck, R.4
Kuchler, W.R.5
Longhi, M.P.6
Hui, H.T.H.7
Tang, C.8
Levitzki, A.9
Gazit, A.10
Chen, I.11
Keri, G.12
Orfi, L.13
Risau, W.14
Flamme, I.15
Ullrich, A.16
Hirthe, K.P.17
Shawver, L.K.18
-
45
-
-
0032474915
-
Synthesis and biological evaluations of 3-substituted indoline-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectively toward particular receptor tyrosine kinases
-
Sun L., Tran N., Tang F., App H., Hirth P., McMahon G., and Tang C. Synthesis and biological evaluations of 3-substituted indoline-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectively toward particular receptor tyrosine kinases. J. Med. Chem. 41 (1998) 2588-2603
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2588-2603
-
-
Sun, L.1
Tran, N.2
Tang, F.3
App, H.4
Hirth, P.5
McMahon, G.6
Tang, C.7
-
46
-
-
19244370071
-
Design, synthesis and evaluation of substituted 3-[(3-or 4-carboxyethylpyrrol-2yo)methylidenyl]indoline-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases
-
Sun L., Tan N., Liang C., Tang F., Rice A., Schreck R., Waltz K., Shawver L.K., McMahon G., and Tang C. Design, synthesis and evaluation of substituted 3-[(3-or 4-carboxyethylpyrrol-2yo)methylidenyl]indoline-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J. Med. Chem. 42 (1999) 5120-5130
-
(1999)
J. Med. Chem.
, vol.42
, pp. 5120-5130
-
-
Sun, L.1
Tan, N.2
Liang, C.3
Tang, F.4
Rice, A.5
Schreck, R.6
Waltz, K.7
Shawver, L.K.8
McMahon, G.9
Tang, C.10
|