Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots

Planta Medica

Volumn 70, Issue 3, 2004, Pages 211-219

  Kimura, Yoshiyuki ^a   Taniguchi, Masahiko ^b   Baba, Kimiye ^b  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

4 hydroxyderricin; Angelica keiskei; Antimetastatic activity; Antitumor activity; Umbelliferae

Indexed keywords

4 HYDROXYDERRICIN; ACETIC ACID ETHYL ESTER; ALCOHOL; ANGELICA EXTRACT; CD4 ANTIGEN; CD8 ANTIGEN; CHALCONE DERIVATIVE; DNA; DOXORUBICIN; UNCLASSIFIED DRUG; XANTHOANGELOL;

ANGELICA; ANGELICA KEISKEI; ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG ISOLATION; FEMALE; IMMUNE SYSTEM; LEWIS CARCINOMA; LYMPHOCYTE; METASTASIS INHIBITION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PLANT ROOT; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR;

ANGELICA; ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; DNA, NEOPLASM; ENDOTHELIUM, VASCULAR; FEMALE; LIVER NEOPLASMS; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS;

ANIMALIA; APIACEAE;

EID: 1842536365     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-815537     Document Type: Article

References (20)

1. Hata K, Kozawa M. Pharmacological studies on Umbelliferous plants XVIII. On the constituents of the roots of Angelica keiskei Koidzumi. Yakugaku Zasshi 1961; 81: 1647-9
2. Kozawa M, Morita N, Baba K, Hata K. The structure of xanthangelol, a new chalcone from the roots of Angelica keiskei Koidzumi (Umbelliferae). Chem Pharm Bull (Tokyo) 1977; 25: 515-6
3. Kozawa M, Morita N, Baba K, Hata K. Chemical components of the roots of Angelica keiskei Koidzumi. II. The structure of the chalcone derivatives. Yakugaku Zasshi (In Japanese) 1978; 98: 210-4
4. Matsuura M, Kimura Y, Nakata K, Baba K, Okuda H. Artery relaxation by chalcones isolated from the roots of Angelica keiskei. Planta Med 2001; 67: 230-5
5. Gorelik E, Segal S, Feldman M. Growth of local tumor exerts a specific inhibitory effect on progression of lung metastases. Int J Cancer 1978; 21: 617-25
6. Gorelik E, Segal S, Feldman M. Control of lung metastasis progression in mice: Role of growth kinetics of 3LL Lewis lung carcinoma and host immune activity. J Nat Cancer Inst 1980; 65: 1257-64
7. Hasegawa H, Saiki I. Oleoyl triterpene glycoside biotransformed from ginseng suppresses growth and metastasis of murine B16-F10 melanoma via immunostimulation. J Trad Med 2000; 17: 186-93
8. Kimura Y. Carp oil or oleic acid but linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. J Nutr 2002; 132: 2069-75
9. Glaces D, Weiss L. Initial arrest patterns of circulating cancer cells: Effects of host sensitization and anticoagulation. In: Weiss L. ed. Fundamental Aspects of Metastasis Amsterdam, North-Holland: 1976: 263-73
10. Hock H, Dorsch M, Kunzendorf Y, Quin Z, Diamanstein T, Blanskenstein T. Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon γ. Proc Natl Acad Sci USA 1993; 90: 2774-8
11. +; T cells in the antitumor immune response. J Exp Med 1998; 188: 2357-68
12. + T cells mediate tumor rejection. J Immunol 2002; 168: 1-4
13. Colomno HP, Forni G. Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now? Immuno Today 1994; 15: 48-51
14. Ma H-L, Whitters MJ, Konz RF, Senices M, Young DA, Grusby MJ, Collins M, Dunussi-Joannopoulos K. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ. J Immunol 2003; 171: 608-15
15. Kimura Y, Baba K. Antitumor and antimetastaic activities of Angelica keisekei roots (Part 1) Isolation of an active substance, xanthoangelol. Int J Cancer 2003; 106: 429-37
16. Kimura Y, Okuda H. Effects of naturally occurring stilbene glycoside from medicinal plants and wine, on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice. J Pharm Pharmacol 2000; 52: 1287-95
17. Kimura Y, Okuda H. Resveratrol isolated from Polygonum cuspidatum roots prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J Nutr 2001; 131: 1844-9
18. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nature Med 1995; 1: 27-31
19. O'Reilly MS, Boem T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 1997; 88: 277-85
20. Folkman J, Klagsbrum M. Angiogenic factors. Science 1987; 235: 442-7