Nonclassical T cells and their antigens in tuberculosis

Cold Spring Harbor Perspectives in Medicine

Volumn 4, Issue 9, 2014, Pages

  De Libero, Gennaro ^b   Singhal, Amit ^a   Lepore, Marco ^b   Mori, Lucia ^a,b  

^a AGENCY FOR SCIENCE   (Singapore)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYROPHILIN 3A1; CD1 ANTIGEN; GLYCOLIPID; LIPID; MEVALONIC ACID; MYCOBACTERIUM ANTIGEN; RIBOFLAVIN; UNCLASSIFIED DRUG; ANTIGEN;

ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ARTICLE; CANCER CONTROL; CELL FUNCTION; CELL MIGRATION; CELL PROTECTION; CELL STRUCTURE; GAMMA DELTA T LYMPHOCYTE; IMMUNE RESPONSE; IMMUNOREGULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS 1; MUCOSAL ASSOCIATED INVARIANT T CELL; NONHUMAN; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUBERCULOSIS; ANTIGEN PRESENTATION; CELLULAR IMMUNITY; HUMAN; IMMUNOLOGY;

ANTIGEN PRESENTATION; ANTIGENS; HUMANS; IMMUNITY, CELLULAR; T-LYMPHOCYTES; TUBERCULOSIS;

EID: 84919998204     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a018473     Document Type: Article

References (117)

1. Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. 2012. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR. Eur J Immunol 42: 2505–2510.
2. Barral DC, Brenner MB. 2007. CD1 antigen presentation: How it works. Nat Rev Immunol 7: 929–941.
3. Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB. 2008. CD1a and MHCclass I followa similar endocytic recycling pathway. Traffic 9: 1446–1457.
4. Batuwangala T, Shepherd D, Gadola SD, Gibson KJ, Zaccai NR, Fersht AR, Besra GS, Cerundolo V, Jones EY. 2004. The crystal structure of human CD1b with a bound bacterial glycolipid. J Immunol 172: 2382–2388.
5. Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB. 1994. Recognition of a lipid antigen by CD1-restricted abþ T cells. Nature 372: 691–694.
6. Behar SM, Dascher CC, Grusby MJ, Wang CR, Brenner MB. 1999. Susceptibility of mice deficient inCD1Dor TAP1 to infection with Mycobacterium tuberculosis. J Exp Med 189: 1973–1980.
7. Bendelac A, Savage PB, Teyton L. 2007. The biology of NKT cells. Annu Rev Immunol 25: 297–336.
8. Brennan PJ, Brigl M, Brenner MB. 2013. Invariant natural killer T cells: An innate activation scheme linked to diverse effector functions. Nat Rev Immunol 13: 101–117.
9. Brossay L, Jullien D, Cardell S, Sydora BC, Burdin N, Modlin RL, Kronenberg M. 1997. Mouse CD1 is mainly expressed on hemopoietic-derived cells. J Immunol 159: 1216–1224.
10. Caccamo N, Sireci G, Meraviglia S, Dieli F, Ivanyi J, Salerno A. 2006. gd T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36: 2681–2690.
11. Chen YH, Chiu NM, Mandal M, Wang N, Wang CR. 1997. Impaired NK1þ T cell development and early IL-4 production in CD1-deficient mice. Immunity 6: 459–467.
12. Chua WJ, Truscott SM, Eickhoff CS, Blazevic A, Hoft DF, Hansen TH. 2012. Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection. Infect Immun 80: 3256–3267.
13. Cohen NR, Garg S, Brenner MB. 2009. Antigen presentation by CD1 lipids, T cells, and NKT cells in microbial immunity. Adv Immunol 102: 1–94.
14. Cooper AM. 2009. Cell-mediated immune responses in tuberculosis. Annu Rev Immunol 27: 393–422.
15. Cosgrove C, Ussher JE, Rauch A, Gartner K, Kurioka A, Huhn MH, Adelmann K, Kang YH, Fergusson JR, immonds P, et al. 2013. Early and nonreversible decrease of CD161þþ/MAIT cells in HIV infection. Blood 121:951–961.
16. Dascher CC, Hiromatsu K, Xiong X, Morehouse C, Watts G, Liu G, McMurray DN, LeClair KP, Porcelli SA, Brenner MB. 2003. Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis. Int Immunol 15: 915–925.
17. De La Barrera SS, Finiasz M, Frias A, Aleman M, arrionuevo P, Fink S, Franco MC, Abbate E, del C Saslain M. 2003. Specific lytic activity against mycobacterial antigens is inversely correlated with the severity of tuberculosis. Clin Exp Immunol 132: 450–461.
18. de La Salle H, Mariotti S, Angenieux C, Gilleron M, Garcia-Alles LF, Malm D, Berg T, Paoletti S, Maıtre B, Mourey L, et al. 2005. Assistance of microbial glycolipid antigen processing by CD1e. Science 310: 1321–1324.
19. De Libero G, Mori L. 2006. Mechanisms of lipid-antigen generation and presentation to T cells. Trends Immunol 27: 485–492.
20. De Libero G, Mori L. 2012. Novel insights into lipid antigen presentation. Trends Immunol 33: 103–111.
21. De Libero G, Collmann A, Mori L. 2009. The cellular and biochemical rules of lipid antigen presentation. Eur J Immunol 39: 2648–2656.
22. De Voss JJ, Rutter K, Schroeder BG, Su H, Zhu Y, Barry CE III. 2000. The salicylate-derivedmycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proc Natl Acad Sci 97: 1252–1257.
23. Dieli F, Taniguchi M, Kronenberg M, Sidobre S, Ivanyi J, Fattorini L, Iona E, Orefici G, De Leo G, Russo D, et al. 2003. An anti-inflammatory role for V a 14 NK T cells in Mycobacterium bovis bacillus Calmette–Gue´rin-infected mice. J Immunol 171: 1961–1968.
24. Dougan SK, Kaser A, Blumberg RS. 2007. CD1 expression on antigen-presenting cells. Curr TopMicrobiol Immunol 314: 113–141.
25. Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D, Milder M, Le Bourhis L, Soudais C, Treiner E, et al. 2011. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 117: 1250–1259.
26. Ernst WA, Maher J, Cho S, Niazi KR, Chatterjee D, Moody DB, Besra GS, Watanabe Y, Jensen PE, Porcelli SA, et al. 1998.Molecular interaction of CD1b with lipoglycan antigens. Immunity 8: 331–340.
27. Facciotti F, Cavallari M, Angenieux C, Garcia-Alles LF, Signorino-Gelo F, Angman L, Gilleron M, Prandi J, Puzo G, Panza L, et al. 2011. Fine tuning by human CD1e of lipidspecific immune responses. Proc Natl Acad Sci 108: 14228–14233.
28. Faure F, Jitsukawa S, Miossec C, Hercend T. 1990. CD1c as a target recognition structure for human T lymphocytes: Analysis with peripheral blood g/d cells. Eur J Immunol 20: 703–706.
29. Fischer K, Scotet E, Niemeyer M, Koebernick H, Zerrahn J, Maillet S, Hurwitz R, Kursar M, Bonneville M, Kaufmann SH, et al. 2004. Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proc Natl Acad Sci 101: 10685–10690.
30. Gagliardi MC, Lemassu A, Teloni R, Mariotti S, Sargentini, V Pardini M, Daffe M, Nisini R. 2007. Cell wall–associated a-glucan is instrumental for Mycobacterium tuberculosis to block CD1 molecule expression and disable the function of dendritic cell derived from infected monocyte. Cell Microbiol 9: 2081–2092.
31. Gansert JL, Kiessler V, Engele M, Wittke F, Rollinghoff M, Krensky AM, Porcelli SA, Modlin RL, Stenger S. 2003. Human NKT cells express granulysin and exhibit antimycobacterial activity. J Immunol 170: 3154–3161.
32. Garcia-Alles LF, Giacometti G, Versluis C, Maveyraud L, de Paepe D, Guiard J, Tranier S, Gilleron M, Prandi J, Hanau D, et al. 2011. Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes. Proc Natl Acad Sci 108: 13230–13235.
33. Gau B, Lemetais A, Lepore M, Garcia-Alles LF, Bourdreux Y, Mori L, Gilleron M, De Libero G, Puzo G, Beau JM, et al. 2013. Simplified deoxypropionate acyl chains for Mycobacterium tuberculosis sulfoglycolipid analogues: Chain length is essential for high antigenicity. Chembiochem 14: 2413–2417.
34. Geerdink D, ter Horst B, Lepore M, Mori L, Puzo G, Hirsch AKH, Gilleron M, de Libero G, Minnaard AJ. 2013. Total synthesis, stereochemical elucidation and biological evaluation of Ac2SGL; a 1,3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis. Chem Sci 4: 709–716.
35. Georgel P, Radosavljevic M, Macquin C, Bahram S. 2011. The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice. Mol Immunol 48: 769–775.
36. Gilleron M, Ronet C, Mempel M, Monsarrat B, Gachelin G, Puzo G. 2001. Acylation state of the phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette–Gue´rin and ability to induce granuloma and recruit natural killer T cells. J Biol Chem 276: 34896–34904.
37. Gilleron M, Stenger S, Mazorra Z, Wittke F, Mariotti S, Bohmer G, Prandi J, Mori L, Puzo G, De Libero G. 2004. Diacylated sulfoglycolipids are novelmycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis. J Exp Med 199: 649–659.
38. Gold MC, Cerri S, Smyk-Pearson S, Cansler ME, Vogt TM, Delepine J, Winata E, Swarbrick GM, Chua WJ, Yu YY, et al. 2010. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol 8: e1000407.
39. Gold MC, Eid T, Smyk-Pearson S, Eberling Y, Swarbrick GM, Langley SM, Streeter PR, Lewinsohn DA, Lewinsohn DM. 2013. Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress. Mucosal Immunol 6: 35–44.
40. Goldfinch N, Reinink P, Connelley T, Koets A, Morrison I, Van Rhijn I. 2010. Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleen. Vet Res 41: 62.
41. Guiard J, Collmann A, Garcia-Alles LF, Mourey L, Brando T, Mori L, Gilleron M, Prandi J, De Libero G, Puzo G. 2009. Fatty acyl structures of Mycobacterium tuberculosis sulfoglycolipid govern T cell response. J Immunol 182: 7030–7037.
42. Han M, Hannick LI, DiBrino M, Robinson MA. 1999. Polymorphism of human CD1 genes. Tissue Antigens 54: 122–127.
43. Harly C, Guillaume Y, Nedellec S, Peigne CM, Monkkonen H, Monkkonen J, Li J, Kuball J, Adams EJ, Netzer S, et al. 2012. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gd T-cell subset. Blood 120: 2269–2279.
44. Hermans IF, Silk JD, Gileadi U, Salio M, Mathew B, Ritter G, Schmidt R, Harris AL, Old L, Cerundolo V. 2003. NKT cells enhance CD4þ and CD8þ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol 171: 5140–5147.
45. Hiromatsu K, Dascher CC, LeClair KP, Sugita M, Furlong ST, Brenner MB, Porcelli SA. 2002. Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens. J Immunol 169: 330–339.
46. Huang S, Gilfillan S, Cella M, Miley MJ, Lantz O, Lybarger L, Fremont DH, Hansen TH. 2005. Evidence for MR1 antigen presentation to mucosal-associated invariant T cells. J Biol Chem 280: 21183–21193.
47. Huang D, Chen CY, Zhang M, Qiu L, Shen Y, Du G, Zhou K, Wang R, Chen ZW. 2012. Clonal immune responses of mycobacterium-specific gd T cells in tuberculous and non-tuberculous tissues during M. tuberculosis infection. PloS ONE 7: e30631.
48. Im JS, Kang TJ, Lee SB, Kim CH, Lee SH, Venkataswamy MM, Serfass ER, Chen B, Illarionov PA, Besra GS, et al. 2008. Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections. Clin Immunol 127: 214–224.
49. Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, et al. 2011. CD1b tetramers bind ab T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med 208: 1741–1747.
50. Kasmar AG, Van Rhijn I, Magalhaes KG, Young DC, Cheng TY, Turner MT, Schiefner A, Kalathur RC, Wilson IA, Bhati M, et al. 2013. Cutting edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo. J Immunol 191: 4499–4503.
51. Kawachi I, Maldonado J, Strader C, Gilfillan S. 2006. MR1-restricted Va 19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response. J Immunol 176: 1618–1627.
52. Kawakami K, Kinjo Y, Uezu K, Yara S, Miyagi K, Koguchi Y, Nakayama T, Taniguchi M, Saito A. 2002. Minimal contribution of Va14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice. Microbiol Immunol 46: 207–210.
53. Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, et al. 2012. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491: 717–723.
54. Layre E, Collmann A, Bastian M, Mariotti S, Czaplicki J, Prandi J, Mori L, Stenger S, De Libero G, Puzo G, et al. 2009. Mycolic acids constitute a scaffold for mycobacterial lipid antigens stimulating CD1-restricted T cells. Chem Biol 16: 82–92.
55. Le Bourhis L, Martin E, Peguillet I, Guihot A, Froux N, Core M, Levy E, Dusseaux M, Meyssonnier V, Premel V, et al. 2010. Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol 11: 701–708.
56. Lepore M, Kalinicenko A, Colone A, Paleja B, Singhal A, Tschumi A, Lee B, Poidinger M, Zolezzi F, Quagliata L, et al. 2014. Parallel T-cell cloning and deep sequencingof human MAIT cells reveal stable oligoclonal TCRb re´pertoire. Nat Comm (in press).
57. Lopez-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ. 2013. The molecular basis for mucosal-associated invariant T cell recognition of MR1 proteins. Proc Natl Acad Sci 110: E1771–E1778.
58. Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, et al. 2013. Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human gd T cells. Immunity 39: 1032–1042.
59. Ly D, Kasmar AG, Cheng TY, de Jong A, Huang S, Roy S, Bhatt A, van Summeren RP, Altman JD, Jacobs WR Jr, et al. 2013. CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens. J Exp Med 210: 729–741.
60. Madigan CA, Cheng TY, Layre E, Young DC, McConnel MJ, Debono CA, Murry JP, Wei JR, Barry CE III, Rodriguez GM, et al. 2012. Lipidomic discovery of deoxysiderophores reveals a revisedmycobactin biosynthesis pathway in Mycobacterium tuberculosis. Proc Natl Acad Sci 109: 1257–1262.
61. Mariotti S, Teloni R, Iona E, Fattorini L, Giannoni F, Romagnoli G, Orefici G, Nisini R. 2002. Mycobacterium tuberculosis subverts the differentiation of human monocytes into dendritic cells. Eur J Immunol 32: 3050–3058.
62. Mariotti S, Teloni R, Iona E, Fattorini L, Romagnoli G, Gagliardi MC, Orefici G, Nisini R. 2004. Mycobacterium tuberculosis diverts a interferon-induced monocyte differentiation from dendritic cells into immunoprivileged macrophage-like host cells. Infect Immun 72: 4385–4392.
63. Martin E, Treiner E, Duban L, Guerri L, Laude H, Toly C, Premel V, Devys A, Moura IC, Tilloy F, et al. 2009. Stepwise development of MAIT cells in mouse and human. PLoS Biol 7: e54.
64. Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR, et al. 2004.Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J Exp Med 200: 1559–1569.
65. Meierovics A, Yankelevich WJ, Cowley SC. 2013. MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection. Proc Natl Acad Sci 110: E3119–E3128.
66. Meraviglia S, Caccamo N, Salerno A, Sireci G, Dieli F. 2010. Partial and ineffective activation of Vg9Vd2 T cells by Mycobacterium uberculosis-infected dendritic cells. J Immunol 185: 1770–1776.
67. Montamat-Sicotte DJ, Millington KA, Willcox CR, Hingley-Wilson S, Hackforth S, Innes J, Kon OM, Lammas DA, Minnikin DE, Besra GS, et al. 2011. A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection. J Clin Invest 121: 2493–2503.
68. Montoya CJ, Catano JC, Ramirez Z, Rugeles MT, Wilson SB, Landay AL. 2008. Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype. Clin Immunol 127: 1–6.
69. Moody DB, Guy MR, Grant E, Cheng TY, Brenner MB, Besra GS, Porcelli SA. 2000a. CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection. J Exp Med 192: 965–976.
70. Moody DB, Ulrichs T, Muhlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, et al. 2000b. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404: 884–888.
71. Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O’Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, et al. 2004. T cell activation by lipopeptide antigens. Science 303: 527–531.
72. Moody DB, Zajonc DM, Wilson IA. 2005. Anatomyof CD1-lipid antigen complexes. Nat Rev Immunol 5: 387–399.
73. Nguyen TK, Koets AP, Santema WJ, van EdenW, Rutten VP, Van Rhijn I. 2009. The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle. Vaccine 27: 4818–4825.
74. O’Garra A, Redford PS, McNab FW, Bloom CI, Wilkinson RJ, Berry MP. 2013. The immune response in tuberculosis. Annu Rev Immunol 31: 475–527.
75. Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, et al. 2013. Recognition of vitamin B metabolites by mucosalassociated invariant T cells. Nat Commun 4: 2142.
76. Pinheiro MB, Antonelli LR, Sathler-Avelar R, Vitelli-Avelar DM, Spindola-de-Miranda S, Guimaraes TM, Teixeira-Carvalho A, Martins-Filho OA, Toledo VP. 2012. CD4-CD8-ab and gd T cells display inflammatory and regulatory potentials during human tuberculosis. PloS ONE 7: e50923.
77. Porcelli SA. 1995. The CD1 family: A third lineage of antigen-presenting molecules. Adv Immunol 59: 1–98.
78. Porcelli SA, Modlin RL. 1999. The CD1 system: Antigenpresenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 17: 297–329.
79. Porcelli S, Yockey CE, Brenner MB, Balk SP. 1993. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4–8 a/b T cells demonstrates preferenial use of several V b genes and an invariant TCR a chain. J Exp Med 178: 1–16.
80. Roark JH, Park SH, Jayawardena J, Kavita U, Shannon M, Bendelac A. 1998. CD1.1 expression by mouse antigenpresenting cells and marginal zone B cells. J Immunol 160: 3121–3127.
81. Rossjohn J, Pellicci DG, Patel O, Gapin L, Godfrey DI. 2012. Recognition of CD1d-restricted antigens by natural killer T cells. Nat Rev Immunol 12: 845–857.
82. Roura-Mir C, Wang L, Cheng TY, Matsunaga I, Dasche CC, Peng SL, Fenton MJ, Kirschning C, Moody DB. 2005. Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J Immunol 175: 1758–1766.
83. Ryll R, Watanabe K, Fujiwara N, Takimoto H, Hasunuma R, Kumazawa Y, Okada M, Yano I. 2001.Mycobacterial cord factor, but not sulfolipid, causes depletion of NKT cells and upregulation of CD1d1 on murine macrophages. Microbes Infect 3: 611–619.
84. Schaible UE, Winau F, Sieling PA, Fischer K, Collins HL, Hagens K, Modlin RL, Brinkmann V, Kaufmann SH. 2003. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat Med 9: 1039–1046.
85. Seshadri C, Shenoy M, Wells RD, Hensley-McBain T, Andersen Nissen E, McElrath MJ, Cheng TY, Moody DB, Hawn TR. 2013. Human CD1a deficiency is common and genetically regulated. J Immunol 191: 1586–1593.
86. Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, et al. 2002. Adaptive immune response of Vg2Vd2þ T cells duringmycobacterial infections. Science 295: 2255–2258.
87. Siegrist MS, Unnikrishnan M, McConnell MJ, Borowsky M, Cheng TY, Siddiqi N, Fortune SM, Moody DB, Rubin EJ. 2009. Mycobacterial Esx-3 is required for mycobactinmediated iron acquisition. Proc Natl Acad Sci 106: 18792–18797.
88. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, et al. 1995. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269: 227–230.
89. Sloma I, Zilber MT, Vasselon T, Setterblad N, Cavallari M, Mori L, De Libero G, Charron D, Mooney N, Gelin C. 2008. Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts. J Immunol 180: 980–987.
90. Snyder-Cappione JE, Nixon DF, Loo CP, Chapman JM, Meiklejohn DA, Melo FF, Costa PR, Sandberg JK, Rodrigues DS, Kallas EG. 2007. Individuals with pulmonary tuberculosis have lower levels of circulating CD1d-restricted NKT cells. J Infect Dis 195: 1361–1364.
91. Sousa AO, Mazzaccaro RJ, Russell RG, Lee FK, Turner OC, Hong S, Van Kaer L, Bloom BR. 2000. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc Natl Acad Sci 97: 4204–4208.
92. Spada FM, Grant EP, Peters PJ, Sugita M, Melian A, Leslie DS, Lee HK, van Donselaar E, Hanson DA, Krensky AM, et al. 2000. Self-recognition of CD1 by g/d T cells: Implications for innate immunity. J Exp Med 191: 937–948.
93. Spencer CT, Abate G, Blazevic A, Hoft DF. 2008. Only a subset of phosphoantigen-responsive g9d2 T cells mediate protective tuberculosis immunity. J Immunol 181: 4471–4484.
94. Stenger S, Niazi KR, Modlin RL. 1998. Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis. J Immunol 161: 3582–3588.
95. Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM. 2003. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med 198:1069–1076.
96. Sugawara I, Yamada H, Mizuno S, Li CY, Nakayama T, Taniguchi M. 2002.Mycobacterial infection in natural killer T cell knockout mice. Tuberculosis (Edinb) 82: 97–104.
97. Tang XZ, Jo J, Tan AT, Sandalova E, Chia A, Tan KC, Lee KH, Gehring AJ, De Libero G, Bertoletti A. 2013. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol 190: 3142–3152.
98. Tatituri RVV, Watts GFM, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, et al. 2013. Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci 110: 1827–1832.
99. Thomas SY, Hou R, Boyson JE, Means TK, Hess C, Olson DP, Strominger JL, Brenner MB, Gumperz JE, Wilson SB, et al. 2003. CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol 171: 2571–2580.
100. Tilloy F, Treiner E, Park SH, Garcia C, Lemonnier F, de la Salle H, Bendelac A, Bonneville M, Lantz O. 1999. An invariant T cell receptor a chain defines a novel TAPindependent major histocompatibility complex class Ib-restricted a/b T cell subpopulation in mammals. J Exp Med 189: 1907–1921.
101. Tourne S, Maitre B, Collmann A, Layre E, Mariotti S, Signorino-Gelo F, Loch C, Salamero J, Gilleron M, Angenieux C, et al. 2008. Cutting edge: A naturally occurring mutation in CD1e impairs lipid antigen presentation. J Immunol 180: 3642–3646.
102. Treiner E, Duban L, Bahram S, Radosavljevic M, Wanner V, Tilloy F, Affaticati P, Gilfillan S, Lantz O. 2003. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422: 164–169.
103. Treiner E, Duban L, Moura IC, Hansen T, Gilfillan S, Lantz O. 2005. Mucosal-associated invariant T (MAIT) cells: An evolutionarily conserved T cell subset. Microbes Infect 7: 552–559.
104. Uldrich AP, LeNours J, Pellicci DG, Gherardin NA, McP erson KG, Lim RT, Patel O, Beddoe T, Gras S, Rossjohn J, et al. 2013. CD1d-lipid antigen recognition by the gd TCR. Nat Immunol 14: 1137–1145.
105. Ulrichs T, Moody DB, Grant E, Kaufmann SH, Porcelli SA. 2003. T-cell responses to CD1-presented lipid antigens inhumans withMycobacterium tuberculosis infection. Infect Immun 71, 3076–3087.
106. Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries N, Godfrey DI, Altman JD, de Jager W, et al. 2013. A conserved human T cell population targets mycobacterial antigens presented by CD1b. Nat Immunol 14: 706–713.
107. Vavassori S, Kumar A, Wan GS, Ramanjaneyulu GS, Cavallari M, El Daker S, Beddoe T, Theodossis A, Williams NK, Gostick E, et al. 2013. Butyrophilin 3A1 binds phosphorylated antigens and stimulates human gd T cells. Nat Immunol 14: 908–916.
108. Wakao H, Yoshikiyo K, Koshimizu U, Furukawa T, Enomoto K, Matsunaga T, Tanaka T, Yasutomi Y, Yamada T, Minakami H, et al. 2013. Expansion of functional human mucosal-associated invariant T cells via reprogramming to pluripotency and redifferentiation. Cell Stem Cell 12: 546–558.
109. Wang X, Chen X, Rodenkirch L, Simonson W, Wernimont S, Ndonye RM, Veerapen N, Gibson D, Howell AR, Besra GS, et al. 2008.Natural killer T-cell autoreactivity leads to a specialized activation state. Blood 112: 4128–4138.
110. Wang H, Fang Z, Morita CT. 2010. Vg2Vd2 T cell receptor recognition of prenyl pyrophosphates is dependent on all CDRs. J Immunol 184: 6209–6222.
111. Watanabe Y, Watari E, Matsunaga I, Hiromatsu K, Dascher CC, Kawashima T, Norose Y, Shimizu K, Takahashi H, Yano I, et al. 2006. BCG vaccine elicits both T-cell mediated and humoral immune responses directed against mycobacterial lipid components. Vaccine 24: 5700–5707.
112. Willcox CR, Pitard V, Netzer S, Couzi L, Salim M, Silberzahn T, Moreau JF, Hayday AC, Willcox BE, Dechanet-Merville J. 2012.Cytomegalovirus and tumor stress surveillance by binding of a human gd T cell antigen receptor to endothelial protein C receptor. Nat Immunol 13: 872–879.
113. Xi X, Han X, Li L, Zhao Z. 2013. Identification of a new tuberculosis antigen recognized by gd T cell receptor. Clin Vaccine Immunol 20: 530–539.
114. Yokobori N, Schierloh P, Geffner L, Balboa L, Romero M, Musella R, Castagnino J, De Stefano G, Aleman M, de la Barrera S, et al. 2009. CD3 expression distinguishes two gdT cell receptor subsets with different phenotype and effector function in tuberculous pleurisy. Clin Exp Immunol 157: 385–394.
115. Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, et al. 2005. Molecular mechanism of lipopeptide presentation by CD1a. Immunity 22: 209–219.
116. Zeng X, Wei YL, Huang J, Newell EW, Yu H, Kidd BA, Kuhns MS, Waters RW, Davis MM, Weaver CT, et al. 2012. gd T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. Immunity 37: 524–534.
117. Zimmer MI, Nguyen HP, Wang B, Xu H, Colmone A, Felio K, Choi HJ, Zhou P, Alegre ML, Wang CR. 2009. Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells. Proc Natl Acad Sci 106: 1909–1914.