Vκ2Vδ2 T cell receptor recognition of prenyl pyrophosphates is dependent on all CDRS

Journal of Immunology

Volumn 184, Issue 11, 2010, Pages 6209-6222

  Wang, Hong ^a   Fang, Zhimei ^a   Morita, Craig T ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCLONAL ANTIBODY; PRENYL PYROPHOSPHATE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY REACTION; ANTIGEN RECOGNITION; ARTICLE; BINDING SITE; CYTOKINE RELEASE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INNATE IMMUNITY; LEUKEMIA CELL LINE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR CLONING; MUTAGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; CELL SEPARATION; CHEMISTRY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE SUBPOPULATION;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; CELL SEPARATION; DIPHOSPHATES; FLOW CYTOMETRY; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; TRANSFECTION;

EID: 77953413811     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000231     Document Type: Article

References (104)

1. Gapin, L. 2009. Where do MAIT cells fit in the family of unconventional T cells? PLoS Biol. 7: e70.
2. Cerundolo, V., J. D. Silk, S. H. Masri, and M. Salio. 2009. Harnessing invariant NKT cells in vaccination strategies. Nat. Rev. Immunol. 9: 28-38.
3. Kronenberg, M., and I. Engel. 2007. On the road: progress in finding the unique pathway of invariant NKT cell differentiation. Curr. Opin. Immunol. 19: 186-193.
4. Morita, C. T., C. M. Parker, M. B. Brenner, and H. Band. 1994. TCR usage and functional capabilities of human gd T cells at birth. J. Immunol. 153: 3979-3988.
5. Parker, C. M., V. Groh, H. Band, S. A. Porcelli, C. Morita, M. Fabbi, D. Glass, J. L. Strominger, and M. B. Brenner. 1990. Evidence for extrathymic changes in the T cell receptor γ/δ repertoire. J. Exp. Med. 171: 1597-1612.
6. Morita, C. T., C. Jin, G. Sarikonda, and H. Wang. 2007. Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2Vδ2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol. Rev. 215: 59-76.
7. Tanaka, Y., C. T. Morita, Y. Tanaka, E. Nieves, M. B. Brenner, and B. R. Bloom. 1995. Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature 375: 155-158.
8. Hintz, M., A. Reichenberg, B. Altincicek, U. Bahr, R. M. Gschwind, A.-K. Kollas, E. Beck, J. Wiesner, M. Eberl, and H. Jomaa. 2001. Identification of (E)-4- hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gd T cells in Escherichia coli. FEBS Lett. 509: 317-322. (Pubitemid 34015963)
9. Puan, K.-J., C. Jin, H. Wang, G. Sarikonda, A. M. Raker, H. K. Lee, M. I. Samuelson, E. Märker-Hermann, L. Pasa-Tolic, E. Nieves, et al. 2007. Preferential recognition of a microbial metabolite by human Vγ2Vδ2 T cells. Int. Immunol. 19: 657-673.
10. Kunzmann, V., E. Bauer, and M. Wilhelm. 1999. γ/δ T-cell stimulation by pamidronate. N. Engl. J. Med. 340: 737-738.
11. Sanders, J. M., S. Ghosh, J. M. W. Chan, G. Meints, H. Wang, A. M. Raker, Y. Song, A. Colantino, A. Burzynska, P. Kafarski, et al. 2004. Quantitative structure-activity relationships for γδ T cell activation by bisphosphonates. J. Med. Chem. 47: 375-384.
12. Bukowski, J. F., C. T. Morita, and M. B. Brenner. 1999. Human γδ T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 11: 57-65.
13. Gober, H. J., M. Kistowska, L. Angman, P. Jenö, L. Mori, and G. De Libero. 2003. Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells. J. Exp. Med. 197: 163-168.
14. Thompson, K., J. Rojas-Navea, and M. J. Rogers. 2006. Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway. Blood 107: 651-654.
15. De Rosa, S. C., J. P. Andrus, S. P. Perfetto, J. J. Mantovani, L. A. Herzenberg, L. A. Herzenberg, and M. Roederer. 2004. Ontogeny of γδ T cells in humans. J. Immunol. 172: 1637-1645.
16. + T cells during mycobacterial infections. Science 295: 2255-2258.
17. García, V. E., P. A. Sieling, J.-H. Gong, P. F. Barnes, K. Uyemura, Y. Tanaka, B. R. Bloom, C. T. Morita, and R. L. Modlin. 1997. Single-cell cytokine analysis of γδ T cell responses to nonpeptide mycobacterial antigens. J. Immunol. 159: 1328-1335.
18. Morita, C. T., S. Verma, P. Aparicio, C. Martinez, H. Spits, and M. B. Brenner. 1991. Functionally distinct subsets of human γ/δ T cells. Eur. J. Immunol. 21: 2999-3007.
19. Cipriani, B., G. Borsellino, F. Poccia, R. Placido, D. Tramonti, S. Bach, L. Battistini, and C. F. Brosnan. 2000. Activation of C-C β-chemokines in human peripheral blood γδ T cells by isopentenyl pyrophosphate and regulation by cytokines. Blood 95: 39-47.
20. Tikhonov, I., C. O. Deetz, R. Paca, S. Berg, V. Lukyanenko, J. K. Lim, and C. D. Pauza. 2006. Human Vγ2Vδ2 T cells contain cytoplasmic RANTES. Int. Immunol. 18: 1243-1251.
21. Spada, F. M., E. P. Grant, P. J. Peters, M. Sugita, A. Melián, D. S. Leslie, H. K. Lee, E. van Donselaar, D. A. Hanson, A. M. Krensky, et al. 2000. Self-recognition of CD1 by γ/δ T cells: implications for innate immunity. J. Exp. Med. 191: 937-948.
22. Dieli, F., M. Troye-Blomberg, J. Ivanyi, J. J. Fournié, A. M. Krensky, M. Bonneville, M. A. Peyrat, N. Caccamo, G. Sireci, and A. Salerno. 2001. Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vγ9/Vδ2 T lymphocytes. J. Infect. Dis. 184: 1082-1085.
23. Dudal, S., C. Turriere, S. Bessoles, P. Fontes, F. Sanchez, J. Liautard, J. P. Liautard, and V. Lafont. 2006. Release of LL-37 by activated human Vγ9Vδ2 T cells: a microbicidal weapon against Brucella suis. J. Immunol. 177: 5533-5539. (Pubitemid 44527627)
24. Wilhelm, M., V. Kunzmann, S. Eckstein, P. Reimer, F. Weissinger, T. Ruediger, and H.-P. Tony. 2003. γδ T cells for immune therapy of patients with lymphoid malignancies. Blood 102: 200-206. (Pubitemid 36759655)
25. Dieli, F., D. Vermijlen, F. Fulfaro, N. Caccamo, S. Meraviglia, G. Cicero, A. Roberts, S. Buccheri, M. D'Asaro, N. Gebbia, et al. 2007. Targeting human γδ T cells with zoledronate and interleukin-2 for immunotherapy of hormonerefractory prostate cancer. Cancer Res. 67: 7450-7457.
26. Bukowski, J. F., C. T. Morita, Y. Tanaka, B. R. Bloom, M. B. Brenner, and H. Band. 1995. Vγ2Vδ2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer. J. Immunol. 154: 998-1006.
27. Morita, C. T., H. K. Lee, H. Wang, H. Li, R. A. Mariuzza, and Y. Tanaka. 2001. Structural features of nonpeptide prenyl pyrophosphates that determine their antigenicity for human γδ T cells. J. Immunol. 167: 36-41.
28. Allison, T. J., C. C. Winter, J. J. Fournié, M. Bonneville, and D. N. Garboczi. 2001. Structure of a human γδ T-cell antigen receptor. Nature 411: 820-824.
29. Bukowski, J. F., C. T. Morita, H. Band, and M. B. Brenner. 1998. Crucial role of TCRγ chain junctional region in prenyl pyrophosphate antigen recognition by γδ T cells. J. Immunol. 161: 286-293.
30. Miyagawa, F., Y. Tanaka, S. Yamashita, B. Mikami, K. Danno, M. Uehara, and N. Minato. 2001. Essential contribution of germline-encoded lysine residues in Jγ1.2 segment to the recognition of nonpeptide antigens by human γδ T cells. J. Immunol. 167: 6773-6779. (Pubitemid 33144167)
31. Yamashita, S., Y. Tanaka, M. Harazaki, B. Mikami, and N. Minato. 2003. Recognition mechanism of non-peptide antigens by human γδ T cells. Int. Immunol. 15: 1301-1307.
32. Morita, C. T., E. M. Beckman, J. F. Bukowski, Y. Tanaka, H. Band, B. R. Bloom, D. E. Golan, and M. B. Brenner. 1995. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 3: 495-507.
33. Lang, F., M. A. Peyrat, P. Constant, F. Davodeau, J. David-Ameline, Y. Poquet, H. Vié, J. J. Fournié, and M. Bonneville. 1995. Early activation of human Vγ9Vδ2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands. J. Immunol. 154: 5986-5994.
34. Pichler, W. J., A. Beeler, M. Keller, M. Lerch, S. Posadas, D. Schmid, Z. Spanou, A. Zawodniak, and B. Gerber. 2006. Pharmacological interaction of drugs with immune receptors: the p-i concept. Allergol. Int. 55: 17-25.
35. Sarikonda, G., H. Wang, K.-J. Puan, X.-H. Liu, H. K. Lee, Y. Song, M. D. Distefano, E. Oldfield, G. D. Prestwich, and C. T. Morita. 2008. Photoaffinity antigens for human γδ T cells. J. Immunol. 181: 7738-7750.
36. Wei, H., D. Huang, X. Lai, M. Chen, W. Zhong, R. Wang, and Z. W. Chen. 2008. Definition of APC presentation of phosphoantigen (E)-4-hydroxy-3-methyl- but-2-enyl pyrophosphate to Vγ2Vδ2 TCR. J. Immunol. 181: 4798-4806.
37. Saito, T., A. Weiss, J. Miller, M. A. Norcross, and R. N. Germain. 1987. Specific antigen-Ia activation of transfected human T cells expressing murine Ti αβ-human T3 receptor complexes. Nature 325: 125-130.
38. Wang, H., H. K. Lee, J. F. Bukowski, H. Li, R. A. Mariuzza, Z. W. Chen, K.-H. Nam, and C. T. Morita. 2003. Conservation of nonpeptide antigen recognition by rhesus monkey Vγ2Vδ2 T cells. J. Immunol. 170: 3696-3706.
39. 13C]-labeled form. Tetrahedron Lett. 43: 5457-5459.
40. Puan, K.-J., H. Wang, T. Dairi, T. Kuzuyama, and C. T. Morita. 2005. fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. FEBS Lett. 579: 3802-3806.
41. Grant, E. P., M. Degano, J. P. Rosat, S. Stenger, R. L. Modlin, I. A. Wilson, S. A. Porcelli, and M. B. Brenner. 1999. Molecular recognition of lipid antigens by T cell receptors. J. Exp. Med. 189: 195-205.
42. Morita, C. T., H. Li, J. G. Lamphear, R. R. Rich, J. D. Fraser, R. A. Mariuzza, and H. K. Lee. 2001. Superantigen recognition by γδ T cells: SEA recognition site for human Vγ2 T cell receptors. Immunity 14: 331-344.
43. Tanaka, Y., S. Sano, E. Nieves, G. De Libero, D. Rosa, R. L. Modlin, M. B. Brenner, B. R. Bloom, and C. T. Morita. 1994. Nonpeptide ligands for human γδ T cells. Proc. Natl. Acad. Sci. USA 91: 8175-8179.
44. Davodeau, F., M.-A. Peyrat, M.-M. Hallet, J. Gaschet, I. Houde, R. Vivien, H. Vie, and M. Bonneville. 1993. Close correlation between Daudi and mycobacterial antigen recognition by human γδ T cells and expression of V9JPC1 γ/V2DJCδ-encoded T cell receptors. J. Immunol. 151: 1214-1223. (Pubitemid 23219257)
45. De Libero, G., G. Casorati, C. Giachino, C. Carbonara, N. Migone, P. Matzinger, and A. Lanzavecchia. 1991. Selection by two powerful antigens may account for the presence of the major population of human peripheral γ/δ T cells. J. Exp. Med. 173: 1311-1322.
46. + T-cell clones frequently recognize Plasmodium falciparum merozoites, Mycobacterium tuberculosis, and group-A streptococci. Int. Arch. Allergy Immunol. 100: 12-18.
47. Baker, N. A., D. Sept, S. Joseph, M. J. Holst, and J. A. McCammon. 2001. Electrostatics of nanosystems: application to microtubules and the ribosome. Proc. Natl. Acad. Sci. USA 98: 10037-10041.
48. Adams, E. J., Y. H. Chien, and K. C. Garcia. 2005. Structure of a γδ T cell receptor in complex with the nonclassical MHC T22. Science 308: 227-231.
49. Borg, N. A., K. S. Wun, L. Kjer-Nielsen, M. C. Wilce, D. G. Pellicci, R. Koh, G. S. Besra, M. Bharadwaj, D. I. Godfrey, J. McCluskey, and J. Rossjohn. 2007. CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature 448: 44-49.
50. Tynan, F. E., H. H. Reid, L. Kjer-Nielsen, J. J. Miles, M. C. Wilce, L. Kostenko, N. A. Borg, N. A. Williamson, T. Beddoe, A. W. Purcell, et al. 2007. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat. Immunol. 8: 268-276.
51. Gagnon, S. J., O. Y. Borbulevych, R. L. Davis-Harrison, R. V. Turner, M. Damirjian, A. Wojnarowicz, W. E. Biddison, and B. M. Baker. 2006. T cell receptor recognition via cooperative conformational plasticity. J. Mol. Biol. 363: 228-243.
52. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384: 134-141.
53. Kjer-Nielsen, L., C. S. Clements, A. W. Purcell, A. G. Brooks, J. C. Whisstock, S. R. Burrows, J. McCluskey, and J. Rossjohn. 2003. A structural basis for the selection of dominant ab T cell receptors in antiviral immunity. Immunity 18: 53-64. (Pubitemid 36120687)
54. Garcia, K. C., M. Degano, L. R. Pease, M. Huang, P. A. Peterson, L. Teyton, and I. A. Wilson. 1998. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 279: 1166-1172.
55. Colf, L. A., A. J. Bankovich, N. A. Hanick, N. A. Bowerman, L. L. Jones, D. M. Kranz, and K. C. Garcia. 2007. How a single T cell receptor recognizes both self and foreign MHC. Cell 129: 135-146.
56. Buslepp, J., H. Wang, W. E. Biddison, E. Appella, and E. J. Collins. 2003. A correlation between TCR Vα docking on MHC and CD8 dependence: implications for T cell selection. Immunity 19: 595-606.
57. Ding, Y. H., K. J. Smith, D. N. Garboczi, U. Utz, W. E. Biddison, and D. C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8: 403-411.
58. Stewart-Jones, G. B., A. J. McMichael, J. I. Bell, D. I. Stuart, and E. Y. Jones. 2003. A structural basis for immunodominant human T cell receptor recognition. Nat. Immunol. 4: 657-663.
59. Reiser, J. B., C. Grégoire, C. Darnault, T. Mosser, A. Guimezanes, A. M. Schmitt-Verhulst, J. C. Fontecilla-Camps, G. Mazza, B. Malissen, and D. Housset. 2002. A T cell receptor CDR3β loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Immunity 16: 345-354.
60. Hoare, H. L., L. C. Sullivan, G. Pietra, C. S. Clements, E. J. Lee, L. K. Ely, T. Beddoe, M. Falco, L. Kjer-Nielsen, H. H. Reid, et al. 2006. Structural basis for a major histocompatibility complex class Ib-restricted T cell response. Nat. Immunol. 7: 256-264.
61. Tynan, F. E., S. R. Burrows, A. M. Buckle, C. S. Clements, N. A. Borg, J. J. Miles, T. Beddoe, J. C. Whisstock, M. C. Wilce, S. L. Silins, et al. 2005. T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat. Immunol. 6: 1114-1122.
62. Reiser, J. B., C. Darnault, C. Grégoire, T. Mosser, G. Mazza, A. Kearney, P. A. van der Merwe, J. C. Fontecilla-Camps, D. Housset, and B. Malissen. 2003. CDR3 loop flexibility contributes to the degeneracy of TCR recognition. Nat. Immunol. 4: 241-247.
63. Reiser, J. B., C. Darnault, A. Guimezanes, C. Grégoire, T. Mosser, A. M. Schmitt-Verhulst, J. C. Fontecilla-Camps, B. Malissen, D. Housset, and G. Mazza. 2000. Crystal structure of a T cell receptor bound to an allogeneic MHC molecule. Nat. Immunol. 1: 291-297.
64. Mazza, C., N. Auphan-Anezin, C. Gregoire, A. Guimezanes, C. Kellenberger, A. Roussel, A. Kearney, P. A. van der Merwe, A. M. Schmitt-Verhulst, and B. Malissen. 2007. How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides? EMBO J. 26: 1972-1983.
65. Gras, S., S. R. Burrows, L. Kjer-Nielsen, C. S. Clements, Y. C. Liu, L. C. Sullivan, M. J. Bell, A. G. Brooks, A. W. Purcell, J. McCluskey, and J. Rossjohn. 2009. The shaping of T cell receptor recognition by self-tolerance. Immunity 30: 193-203.
66. Reinherz, E. L., K. Tan, L. Tang, P. Kern, J. Liu, Y. Xiong, R. E. Hussey, A. Smolyar, B. Hare, R. Zhang, et al. 1999. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science 286: 1913-1921.
67. Hennecke, J., A. Carfi, and D. C. Wiley. 2000. Structure of a covalently stabilized complex of a human αβ T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. EMBO J. 19: 5611-5624.
68. Maynard, J., K. Petersson, D. H. Wilson, E. J. Adams, S. E. Blondelle, M. J. Boulanger, D. B. Wilson, and K. C. Garcia. 2005. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity 22: 81-92.
69. Li, Y., Y. Huang, J. Lue, J. A. Quandt, R. Martin, and R. A. Mariuzza. 2005. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. EMBO J. 24: 2968-2979.
70. Deng, L., R. J. Langley, P. H. Brown, G. Xu, L. Teng, Q. Wang, M. I. Gonzales, G. G. Callender, M. I. Nishimura, S. L. Topalian, and R. A. Mariuzza. 2007. Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor. Nat. Immunol. 8: 398-408.
71. Dai, S., E. S. Huseby, K. Rubtsova, J. Scott-Browne, F. Crawford, W. A. Macdonald, P. Marrack, and J. W. Kappler. 2008. Crossreactive T cells spotlight the germline rules for αβ T cell-receptor interactions with MHC molecules. Immunity 28: 324-334.
72. Brenner, M. B., J. L. Strominger, and M. S. Krangel. 1988. The γδ T cell receptor. Adv. Immunol. 43: 133-192.
73. Heilig, J. S., and S. Tonegawa. 1986. Diversity of murine γ genes and expression in fetal and adult T lymphocytes. Nature 322: 836-840.
74. Scotet, E., L. O. Martinez, E. Grant, R. Barbaras, P. Jenö, M. Guiraud, B. Monsarrat, X. Saulquin, S. Maillet, J. P. Estève, et al. 2005. Tumor recognition following Vg9Vd2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity 22: 71-80. (Pubitemid 40143452)
75. Delfau, M.-H., A. J. Hance, D. Lecossier, E. Vilmer, and B. Grandchamp. 1992. Restricted diversity of Vγ9-JP rearrangements in unstimulated human γ/δ T lymphocytes. Eur. J. Immunol. 22: 2437-2443.
76. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334: 395-402.
77. Rock, E. P., P. R. Sibbald, M. M. Davis, and Y. H. Chien. 1994. CDR3 length in antigen-specific immune receptors. J. Exp. Med. 179: 323-328.
78. Allison, T. J., and D. N. Garboczi. 2002. Structure of γδ T cell receptors and their recognition of non-peptide antigens. Mol. Immunol. 38: 1051-1061.
79. Davodeau, F., M. A. Peyrat, M. M. Hallet, I. Houde, H. Vie, and M. Bonneville. 1993. Peripheral selection of antigen receptor junctional features in a major human γδ subset. Eur. J. Immunol. 23: 804-808.
80. Borg, N. A., L. K. Ely, T. Beddoe, W. A. Macdonald, H. H. Reid, C. S. Clements, A. W. Purcell, L. Kjer-Nielsen, J. J. Miles, S. R. Burrows, et al. 2005. The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nat. Immunol. 6: 171-180.
81. Manning, T. C., C. J. Schlueter, T. C. Brodnicki, E. A. Parke, J. A. Speir, K. C. Garcia, L. Teyton, I. A. Wilson, and D. M. Kranz. 1998. Alanine scanning mutagenesis of an αβ T cell receptor: mapping the energy of antigen recognition. Immunity 8: 413-425.
82. Ishizuka, J., G. B. E. Stewart-Jones, A. van der Merwe, J. I. Bell, A. J. McMichael, and E. Y. Jones. 2008. The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vβ domain. Immunity 28: 171-182.
83. Havran, W. L., Y. H. Chien, and J. P. Allison. 1991. Recognition of self antigens by skin-derived T cells with invariant g d antigen receptors. Science 252: 1430-1432.
84. - α/β T cells demonstrates preferential use of several Vβb genes and an invariant TCR α chain. J. Exp. Med. 178: 1-16.
85. Shin, S., R. El-Diwany, S. Schaffert, E. J. Adams, K. C. Garcia, P. Pereira, and Y.-H. Chien. 2005. Antigen recognition determinants of γδ T cell receptors. Science 308: 252-255. (Pubitemid 40558860)
86. Adams, E. J., P. Strop, S. Shin, Y. H. Chien, and K. C. Garcia. 2008. An autonomous CDR3δ is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by γδ T cells. Nat. Immunol. 9: 777-784.
87. Pellicci, D. G., O. Patel, L. Kjer-Nielsen, S. S. Pang, L. C. Sullivan, K. Kyparissoudis, A. G. Brooks, H. H. Reid, S. Gras, I. S. Lucet, et al. 2009. Differential recognition of CD1d-α-galactosyl ceramide by the Vβ8.2 and Vβ 7 semi-invariant NKT T cell receptors. Immunity 31: 47-59.
88. Wun, K. S., N. A. Borg, L. Kjer-Nielsen, T. Beddoe, R. Koh, S. K. Richardson, M. Thakur, A. R. Howell, J. P. Scott-Browne, L. Gapin, et al. 2008. A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR. J. Exp. Med. 205: 939-949.
89. Godfrey, D. I., J. Rossjohn, and J. McCluskey. 2008. The fidelity, occasional promiscuity, and versatility of T cell receptor recognition. Immunity 28: 304-314.
90. Hahn, M., M. J. Nicholson, J. Pyrdol, and K. W. Wucherpfennig. 2005. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat. Immunol. 6: 490-496.
91. Deng, L., and R. A. Mariuzza. 2007. Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors. Trends Biochem. Sci. 32: 500-508.
92. Sicard, H., S. Ingoure, B. Luciani, C. Serraz, J.-J. Fournié, M. Bonneville, J. Tiollier, and F. Romagné. 2005. In vivo immunomanipulation of Vγ9Vδ2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model. J. Immunol. 175: 5471-5480.
93. Daubenberger, C. A., M. Salomon, W. Vecino, B. Hübner, H. Troll, R. Rodriques, M. E. Patarroyo, and G. Pluschke. 2001. Functional and structural similarity of Vγ9Vδ2 T cells in humans and Aotus monkeys, a primate infection model for Plasmodium falciparum malaria. J. Immunol. 167: 6421-6430.
94. Xiong, X., C. T. Morita, J. F. Bukowski, M. B. Brenner, and C. C. Dascher. 2004. Identification of guinea pig γδ T cells and characterization during pulmonary tuberculosis. Vet. Immunol. Immunopathol. 102: 33-44.
95. Kato, Y., Y. Tanaka, H. Tanaka, S. Yamashita, and N. Minato. 2003. Requirement of species-specific interactions for the activation of human γδ T cells by pamidronate. J. Immunol. 170: 3608-3613. (Pubitemid 36359229)
96. + γδ T cells to protein and nonprotein antigens of Mycobacterium bovis. Infect. Immun. 70: 6114-6120.
97. Green, A. E., A. Lissina, S. L. Hutchinson, R. E. Hewitt, B. Temple, D. James, J. M. Boulter, D. A. Price, and A. K. Sewell. 2004. Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clin. Exp. Immunol. 136: 472-482.
98. Scott-Browne, J. P., J. L. Matsuda, T. Mallevaey, J. White, N. A. Borg, J. McCluskey, J. Rossjohn, J. Kappler, P. Marrack, and L. Gapin. 2007. Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat. Immunol. 8: 1105-1113.
99. Mallevaey, T., J. P. Scott-Browne, J. L. Matsuda, M. H. Young, D. G. Pellicci, O. Patel, M. Thakur, L. Kjer-Nielsen, S. K. Richardson, V. Cerundolo, et al. 2009. T cell receptor CDR2β and CDR3β loops collaborate functionally to shape the iNKT cell repertoire. Immunity 31: 60-71.
100. Florence, W. C., C. Xia, L. E. Gordy, W. Chen, Y. Zhang, J. Scott-Browne, Y. Kinjo, K. O. Yu, S. Keshipeddy, D. G. Pellicci, et al. 2009. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO J. 28: 3579-3590.
101. Morita, C. T., R. A. Mariuzza, and M. B. Brenner. 2000. Antigen recognition by human γδ T cells: pattern recognition by the adaptive immune system. Springer Semin. Immunopathol. 22: 191-217.
102. Evans, P. S., P. J. Enders, C. Yin, T. J. Ruckwardt, M. Malkovsky, and C. D. Pauza. 2001. In vitro stimulation with a non-peptidic alkylphosphate expands cells expressing Vγ2-Jγ1.2/Vδ2 T-cell receptors. Immunology 104: 19-27.
103. Chien, Y.-H., and M. Bonneville. 2006. γδ T cell receptors. Cell. Mol. Life Sci. 63: 2089-2094.
104. Born, W. K., and R. L. O'Brien. 2009. Antigen-restricted γδ T-cell receptors? Arch. Immunol. Ther. Exp. (Warsz.) 57: 129-135.