Recognition of vitamin B metabolites by mucosal-associated invariant T cells

Nature Communications

Volumn 4, Issue , 2013, Pages

  Patel, Onisha ^a   Kjer Nielsen, Lars ^b   Le Nours, Jérôme ^a   Eckle, Sidonia B G ^b   Birkinshaw, Richard ^a   Beddoe, Travis ^a   Corbett, Alexandra J ^b   Liu, Ligong ^c   Miles, John J ^d,e   Meehan, Bronwyn ^b   Reantragoon, Rangsima ^b   Sandoval Romero, Maria L ^a   Sullivan, Lucy C ^b   Brooks, Andrew G ^b   Chen, Zhenjun ^b   Fairlie, David P ^c   McCluskey, James ^b   Rossjohn, Jamie ^a,e  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; MUCOSAL ASSOCIATED INVARIANT T CELL ANTIGEN RECEPTOR; PATTERN RECOGNITION RECEPTOR; RIBOFLAVIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN; LIGAND; METABOLISM; METABOLITE; MUCUS; VITAMIN;

ALPHA CHAIN; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; IMMUNOSTIMULATION; PROTEIN INTERACTION; T LYMPHOCYTE;

CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FOLIC ACID; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTESTINAL MUCOSA; JURKAT CELLS; MOLECULAR DOCKING SIMULATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN REFOLDING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT PROTEINS; RIBOFLAVIN; T-LYMPHOCYTES;

EID: 84880288515     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3142     Document Type: Article

References (40)

1. Treiner, E. et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422, 164-169 (2003). (Pubitemid 36362748)
2. Tang, X.-Z. et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J. Immunol. 190, 3142-3152 (2013).
3. Le Bourhis, L. et al. Antimicrobial activity of mucosal-associated invariant T cells. Nat. Immunol. 11, 701-708 (2010).
4. Gold, M. C. et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 8, e1000407 (2010).
5. Godfrey, D. I., Rossjohn, J. & McCluskey, J. Fighting infection with your MAITs. Nat. Immunol. 11, 693-695 (2010).
6. Gold, M. C. & Lewinsohn, D. M. Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Nat. Rev. Microbiol. 11, 14-19 (2013).
7. Miyazaki, Y., Miyake, S., Chiba, A., Lantz, O. & Yamamura, T. Mucosalassociated invariant T cells regulate Th1 response in multiple sclerosis. Int. Immunol. 23, 529-535 (2011).
8. Le Bourhis, L. et al. Mucosal-associated invariant T cells: unconventional development and function. Trends Immunol. 32, 212-218 (2011).
9. Chua, W. J. et al. Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection. Infect. Immun. 80, 3256-3267 (2012).
10. Cosgrove, C. et al. Early and non-reversible decrease of CD161\+ \+/MAIT cells in HIV infection. Blood 121, 951-961 (2012).
11. Leeansyah, E. et al. Activation, exhaustion and persistent decline of the antimicrobial MR1-restricted MAIT cell population in chronic HIV-1 infection. Blood 121, 1124-1135 (2012).
12. Vera, G. et al. Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans. Mol. Cell. Biol. 33, 701-711 (2013).
13. Rossjohn, J., Pellicci, D. G., Patel, O., Gapin, L. & Godfrey, D.I. Recognition of CD1d-restricted antigens by natural killer T cells. Nat. Rev. Immunol. 12, 845-857 (2012).
14. Godfrey, D. I. & Rossjohn, J. New ways to turn on NKT cells. J. Exp. Med. 208, 1121-1125 (2011).
15. Huang, S. et al. Evidence for MR1 antigen presentation to mucosal-associated invariant T cells. J. Biol. Chem. 280, 21183-21193 (2005). (Pubitemid 40805680)
16. Kjer-Nielsen, L. et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491, 717-723 (2012).
17. Tilloy, F. et al. An invariant T Cell receptor alpha chain defines a novel TAPindependent major histocompatibility complex class Ib-restricted alpha/beta T Cell subpopulation in mammals. J. Exp. Med. 189, 1907-1921 (1999). (Pubitemid 29295889)
18. Turner, S. J., Doherty, P. C., McCluskey, J. & Rossjohn, J. Structural determinants of T-cell receptor bias in immunity. Nat. Rev. Immunol. 6, 883-894 (2006). (Pubitemid 44851731)
19. Godfrey, D. I. et al. Antigen recognition by CD1d-restricted NKT T cell receptors. Semin. Immunol. 22, 61-67 (2010).
20. Bendelac, A., Savage, P. B. & Teyton, L. The biology of NKT cells. Annu. Rev. Immunol. 25, 297-336 (2007). (Pubitemid 46697911)
21. Huang, S. et al. MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. Proc. Natl Acad. Sci. USA 106, 8290-8295 (2009).
22. Tynan, F. E. et al. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat. Immunol. 8, 268-276 (2007). (Pubitemid 46745376)
23. Borg, N. A. et al. CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature 448, 44-49 (2007). (Pubitemid 47037002)
24. Gras, S. et al. A structural voyage toward an understanding of the MHC-Irestricted immune response: lessons learned and much to be learned. Immunol. Rev. 250, 61-81 (2012).
25. Godfrey, D. I., Rossjohn, J. & McCluskey, J. The fidelity, occasional promiscuity, and versatility of T cell receptor recognition. Immunity 28, 304-314 (2008). (Pubitemid 351343861)
26. Girardi, E. & Zajonc, D. M. Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells. Immunol. Rev. 250, 167-179 (2012).
27. Reantragoon, R. et al. Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. J. Exp. Med. 209, 761-774 (2012).
28. Mikkelsen, T. S. et al. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447, 167-177 (2007). (Pubitemid 46763085)
29. Patel, O. et al. Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nat. Immunol. 13, 857-863 (2012).
30. Girardi, E. et al. Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens. Nat. Immunol. 13, 851-856 (2012).
31. Pellicci, D. G. et al. Recognition of [beta]-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat. Immunol. 12, 827-833 (2011).
32. Wun, K. S. et al. A molecular basis for the exquisite Cd1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity 34, 327-339 (2011).
33. Garboczi, D. N., Hung, D. T. & Wiley, D. C. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc. Natl Acad. Sci. USA 89, 3429-3433 (1992).
34. Leslie, A. G. The integration of macromolecular diffraction data. Acta Crystallogr. D Biol. Crystallogr. 62, 48-57 (2006).
35. CCP4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50, 760-763 (1994).
36. Zwart, P. H. et al. Automated structure solution with the PHENIX suite. Methods Mol. Biol. 426, 419-435 (2008).
37. Schuttelkopf, A. W. & van Aalten, D. M. F. PRODRG: a tool for highthroughput crystallography of protein-ligand complexes. Acta Crystallogr. Biol. Crystallogr. 60, 1355-1363 (2004). (Pubitemid 41079731)
38. Bricogne, G. et al. Auto Buster, Version 1.6.0 (Global Phasing Ltd, Cambridge, UK, 2011).
39. DeLano, W. L. The PyMOL Molecular Graphics System. http://www.pymol.org (2002).
40. Kjer-Nielsen, L. et al. A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity 18, 53-64 (2003). (Pubitemid 36120687)