Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities

European Journal of Medicinal Chemistry

Volumn 92, Issue , 2015, Pages 115-123

  Alanazi, Amer M ^a   El Azab, Adel S ^a,b   Al Suwaidan, Ibrahim A ^a   Eltahir, Kamal Eldin H ^a   Asiri, Yousif A ^a   Abdel Aziz, Naglaa I ^c   Abdel Aziz, Alaa A M ^a,c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Al Azhar University   (Egypt)

^c University of Mansoura   (Egypt)

Author keywords

Analgesic activity; Anti inflammatory activity; COX 2 inhibitors; Molecular docking; Phthalimides

Indexed keywords

1 (3,4,5 TRIMETHOXYBENZYL)PYRROLIDINE 2,5 DIONE; 2 (3,4,5 TRIMETHOXYBENZYL) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3,4,5 TRIMETHOXYBENZYL) 3A,4,7,7A TETRAHYDRO 1H ISOINDOLE 1,3(2H) DIONE; 2 (3,4,5 TRIMETHOXYBENZYL)ISOINDOLINE 1,3 DIONE; 2 (4 FLUOROBENZYL) 3A,4,7,7A TETRAHYDRO 1H ISOINDOLE 1,3 (2H) DIONE; 2 (4 FLUOROBENZYL) 5 METHYLISOINDOLINE 1,3 DIONE; 2 (4 METHOXYBENZYL) 5 METHYLISOINDOLINE 1,3 DIONE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 4,5,6,7 TETRACHLORO 2 (4 FLUOROBENZYL)ISOINDOLINE 1,3 DIONE; 4,5,6,7 TETRACHLORO 2 (4 METHOXYBENZYL)ISOINDOLINE 1,3 DIONE; 5 (TERT BUTYL) 2 (3,4,5 TRIMETHOXYBENZYL)ISOINDOLINE 1,3 DIONE; 5 (TERT BUTYL) 2 (4 FLUOROBENZYL)ISOINDOLINE 1,3 DIONE; 5 (TERT BUTYL) 2 (4 METHOXYBENZYL)ISOINDOLINE 1,3 DIONE; 5 METHYL 2 (3,4,5 TRIMETHOXYBENZYL)ISOINDOLINE 1,3 DIONE; 5 NITRO 2 (3,4,5 TRIMETHOXYBENZYL)ISOINDOLINE 1,3 DIONE; 5,6 DICHLORO 2 (3,4,5 TRIMETHOXYBENZYL)ISOINDOLINE 1,3 DIONE; 5,6 DICHLORO 2 (4 FLUOROBENZYL)ISOINDOLINE 1,3 DIONE; 5,6 DICHLORO 2 (4 METHOXYBENZYL)ISOINDOLINE 1,3 DIONE; 6 (3,4,5 TRIMETHOXYBENZYL) 5H PYRROLO[3,4 B]PYRAZINE 5,7(6H DIONE; ACETIC ACID; ACID ANHYDRIDE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; PHTHALIMIDE DERIVATIVE; UNCLASSIFIED DRUG; ANALGESIC AGENT; CARRAGEENAN; NONSTEROID ANTIINFLAMMATORY AGENT; PHTHALIMIDE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MALE; MELTING POINT; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; EDEMA; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLOOXYGENASE 2 INHIBITORS; DRUG DESIGN; EDEMA; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHTHALIMIDES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84919934270     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.12.039     Document Type: Article

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