Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 9, 2005, Pages 3079-3091

  Sano, Hiroko ^a   Noguchi, Tomomi ^a   Tanatani, Aya ^a   Hashimoto, Yuichi ^a   Miyachi, Hiroyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

COX 1; COX 1 selectivity; Indole derivatives; Indoline derivatives

Indexed keywords

1 (3,5 DIMETHYLPHENYL) 4 NITRO 1H INDOLE; 1 (3,5 DIMETHYLPHENYL) 5 METHANESULFONYLAMINO 1H INDOLE; 1 (3,5 DIMETHYLPHENYL) 5 METHOXY 1H INDOLE; 1 (3,5 DIMETHYLPHENYL) 5 METHYL 1H INDOLE; 1 (3,5 DIMETHYLPHENYL) 5 NITRO 1H INDOLE; 1 (3,5 DIMETHYLPHENYL) 5 TRIFLUOROMETHANESULFONYLAMINO 1H INDOLE; 1 (3,5 DIMETHYLPHENYL) 6 NITRO 1H INDOLE; 1 (3,5 DIMETHYLPHENYL) 7 NITRO 1H INDOLE; 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 4 NITRO 1H INDOLE; 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 5 METHANESULFONYLAMINO 1H INDOLE; 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 5 METHOXY 1H INDOLE; 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 5 METHYL 1H INDOLE; 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 5 NITRO 1H INDOLE; 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 5 TRIFLUOROMETHANESULFONYLAMINO 1H INDOLE; 2,3 DIHYDRO 5 HYDROXY 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 4 AMINO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 5 AMINO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 5 AMINO 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 5 BROMO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 5 BROMO 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 5 CYANO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 5 CYANO 2,3 DIHYDRO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 5 HYDROXY 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 6 AMINO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; 7 AMINO 1 (3,5 DIMETHYLPHENYL) 1H INDOLE; INDOLE DERIVATIVE; INDOLIZIDINE DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; THALIDOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER THERAPY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; INFLAMMATORY DISEASE; INHIBITION KINETICS; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

EID: 16244383547     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.03.002     Document Type: Article

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