dNTP deficiency induced by HU via inhibiting ribonucleotide reductase affects neural tube development

Toxicology

Volumn 328, Issue , 2015, Pages 142-151

  Guan, Zhen ^a   Wang, Xiuwei ^a   Dong, Yanting ^b   Xu, Lin ^a   Zhu, Zhiqiang ^a   Wang, Jianhua ^a   Zhang, Ting ^a   Niu, Bo ^a  

^a CAPITAL INSTITUTE OF PEDIATRICS   (China)

^b SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; DNA damage; Hydroxyurea (HU); Neural tube defects (NTDs); Proliferation; Ribonucleotide reductase (RNR)

Indexed keywords

CASPASE 3; DEOXYNUCLEOSIDE TRIPHOSPHATE; DNA NUCLEOTIDYLEXOTRANSFERASE; FOLIC ACID; HISTONE H3; HYDROXYUREA; NUCLEOTIDE; RIBONUCLEOTIDE REDUCTASE; UNCLASSIFIED DRUG; CASP3 PROTEIN, MOUSE; DEOXYRIBONUCLEOTIDE; ENZYME INHIBITOR; HISTONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FOLATE METABOLISM; GESTATIONAL AGE; HISTONE PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NEURAL TUBE DEFECT; NICK END LABELING; NONHUMAN; WESTERN BLOTTING; ABNORMALITIES, DRUG-INDUCED; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BRAIN; C57BL MOUSE; CELL PROLIFERATION; CHEMICALLY INDUCED; CONGENITAL MALFORMATION; DOWN REGULATION; DRUG EFFECTS; EMBRYOLOGY; ENVIRONMENTAL EXPOSURE; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; PREGNANCY; TIME;

MURINAE; MUS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; APOPTOSIS; BRAIN; CASPASE 3; CELL PROLIFERATION; DEOXYRIBONUCLEOTIDES; DNA DAMAGE; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; GESTATIONAL AGE; HISTONES; HYDROXYUREA; MATERNAL EXPOSURE; MICE, INBRED C57BL; NEURAL TUBE; NEURAL TUBE DEFECTS; PHOSPHORYLATION; PREGNANCY; RIBONUCLEOTIDE REDUCTASES; TIME FACTORS;

EID: 84919934006     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.12.001     Document Type: Article

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