Sensitive Windows of Skeletal Development in Rabbits Determined by Hydroxyurea Exposure at Different Times throughout Gestation

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 95, Issue 3, 2012, Pages 238-249

  Campion, Sarah N ^a   Davenport, Scott J ^a   Nowland, William S ^a   Cappon, Gregg D ^a   Bowman, Christopher J ^a   Hurtt, Mark E ^a  

^a PFIZER INC   (United States)

Author keywords

Axial skeleton; Hydroxyurea; Rabbits; Teratogenicity

Indexed keywords

HYDROXYUREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DEVELOPMENT; CESAREAN SECTION; CONTROLLED STUDY; CRANIOFACIAL DEVELOPMENT; CRANIOFACIAL MORPHOLOGY; EXPERIMENTAL RABBIT; FEMALE; FETUS; FETUS DEVELOPMENT; FOOD INTAKE; GESTATIONAL AGE; NONHUMAN; PHENOTYPE; PREGNANCY RATE; PRIORITY JOURNAL; SINGLE DRUG DOSE; SKELETON MALFORMATION; VISCERA; WEIGHT GAIN;

ANIMALS; BONE AND BONES; BONE DEVELOPMENT; CESAREAN SECTION; CRANIOFACIAL ABNORMALITIES; FEMALE; FETUS; HYDROXYUREA; MATERNAL EXPOSURE; MICE; PHENOTYPE; PREGNANCY; RABBITS; RATS; TIME FACTORS; VISCERA;

EID: 84862595011     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.21013     Document Type: Article

References (28)

1. Aliverti V, Bonanomi L, Giavini E. 1980a. Hydroxyurea as a reference standard in teratological screening. Comparison of the embryotoxic and teratogenic effects following single intraperitoneal or repeated oral administrations to pregnant rats. Arch Toxicol Suppl 4:239-247.
2. Augustine-Rauch KA, Zhang QJ, Posobiec L, Mirabile R, DeBoer LS, Solomon HM, Wier PJ. 2004a. SB-236057: critical window of sensitivity study and embryopathy of a potent musculoskeletal teratogen. Birth Defects Res 70(10):773-788.
3. Barr M, Jr., Beaudoin AR. 1981. An exploration of the role of hydroxyurea injection time in fetal growth and teratogenesis in rats. Teratology 24(2):163-167.
4. Branch S, Francis BM, Brownie CF, Chernoff N. 1996. Teratogenic effects of the demethylating agent 5-aza-2'-deoxycytidine in the Swiss Webster mouse. Toxicology 112(1):37-43.
5. Campion SN, Bowman CJ, Cappon GD, Harrison A, Finch GL, Hurtt ME. Developmental toxicity of lersivirine in rabbits when administered throughout organogenesis and when limited to sensitive windows of axial skeletal development.
6. Chahoud I, Kuriyama SN, Paumgartten FJ. 2002. Maternal protein-and-energy restriction reduces the developmental toxicity of cyclophosphamide and hydroxyurea in rats. Toxicology 179(1-2):137-149.
7. Chaube S, Murphy ML. 1966. The effects of hydroxyurea and related compounds on the rat fetus. Cancer Res 26(7):1448-1457.
8. Cherrington JW, Chernoff N. 2002. Periods of vertebral column sensitivity to boric acid treatment in CD-1 mice in utero. Reprod Toxicol 16(3):237-243.
9. Couture LA, Harris MW, Birnbaum LS. 1990. Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Fund. Appl. Toxicol. 15(1):142-150.
10. Dawson AB. 1926. A note on the staining of the skeleton of cleared specimens with Alizarin Red S. Stain Technol. 1:123-124.
11. DeSesso JM, Goeringer GC. 1990. The nature of the embryo-protective interaction of propyl gallate with hydroxyurea. Reprod Toxicol 4(2):145-152.
12. DeSesso JM, Jordan RL. 1977. Drug-induced limb dysplasias in fetal rabbits. Teratology 15(2):199-211.
13. Iulianella A, Lohnes D. 1997. Contribution of retinoic acid receptor gamma to retinoid-induced craniofacial and axial defects. Dev Dynam 209(1):92-104.
14. Karsenty G. 1998. Genetics of skeletogenesis. Dev Genet 22(4):301-313.
15. Kawanishi CY, Hartig P, Bobseine KL, Schmid J, Cardon M, Massenburg G, Chernoff N. 2003. Axial skeletal and Hox expression domain alterations induced by retinoic acid, valproic acid, and bromoxynil during murine development. J Biochem Mol Toxicol 17(6):346-356.
16. Liebelt EL, Balk SJ, Faber W, Fisher JW, Hughes CL, Lanzkron SM, Lewis KM, Marchetti F, Mehendale HM, Rogers JM, Shad AT, Skalko RG, Stanek EJ. 2007. NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea. Birth Defects Res B Dev Reprod Toxicol 80(4):259-366.
17. Millicovsky G, DeSesso JM. 1980. Cardiovascular alterations in rabbit embryos in situ after a teratogenic dose of hydroxyurea: an in vivo microscopic study. Teratology 22(1):115-124.
18. Millicovsky G, DeSesso JM, Kleinman LI, Clark KE. 1981. Effects of hydroxyurea on hemodynamics of pregnant rabbits: a maternally mediated mechanism of embryotoxicity. Am J Obstet Gynecol 140(7):747-752.
19. Murphy ML, Chaube S. 1964. Preliminary survey of hydroxyurea (NSC-32065) as a teratogen. Cancer Chemoth Rep 40:1-7.
20. Narotsky MG, Schmid JE, Andrews JE, Kavlock RJ. 1998. Effects of boric acid on axial skeletal development in rats. Biol Trace Elem Res 66(1-3):373-394.
21. Rogers JM, Mole ML. 1997. Critical periods of sensitivity to the developmental toxicity of inhaled methanol in the CD-1 mouse. Teratology 55(6):364-372.
22. Shifley ET, Cole SE. 2007. The vertebrate segmentation clock and its role in skeletal birth defects. Birth Defects Res C Embryo Today 81(2):121-133.
23. Soukup S, Takacs E, Warkany J. 1967. Chromosome changes in embryos treated with various teratogens. J Embryol Exp Morphol 18(2):215-226.
24. Stuckhardt JL, Poppe SM. 1984. Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing. Teratog Carcinog Mutagen 4(2):181-188.
25. Tiboni GM, Marotta F, Del Corso A, Giampietro F. 2006. Defining critical periods for itraconazole-induced cleft palate, limb defects and axial skeletal malformations in the mouse. Toxicol Lett 167(1):8-18.
26. Wilson JG. 1965. Embryological considerations in teratology. Ann NY Acad Sci 123:219-227.
27. Wise LD, Winkelmann CT. 2009. Evaluation of hydroxyurea-induced fetal skeletal changes in Dutch belted rabbits by micro-computed tomography and alizarin red staining. Birth Defects Res B Dev Reprod Toxicol 86(3):220-226.
28. Yan J, Hales BF. 2005. Activator protein-1 (AP-1) DNA binding activity is induced by hydroxyurea in organogenesis stage mouse embryos. Toxicol Sci 85(2):1013-1023.