Fascin-1 as a biomarker and prospective therapeutic target in colorectal cancer

Expert Review of Molecular Diagnostics

Volumn 15, Issue 1, 2015, Pages 41-48

  Adams, Josephine C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Actin; adenocarcinoma; adenoma; cell migration; filopodia; focal adhesion; invasion; KRAS; metastasis

Indexed keywords

BIOLOGICAL MARKER; FASCIN; ACTIN BINDING PROTEIN; CARRIER PROTEIN; FSCN1 PROTEIN, HUMAN; TUMOR MARKER;

ACTIN FILAMENT; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CARCINOMA CELL; CLINICAL RESEARCH; COLORECTAL CANCER; CYTOSKELETON; DRUG TARGETING; HUMAN; METASTASIS; PROTEIN FUNCTION; TUMOR CELL LINE; UPREGULATION; ANIMAL; COLORECTAL NEOPLASMS; GENE EXPRESSION; METABOLISM; MOLECULARLY TARGETED THERAPY;

ANIMALS; BIOMARKERS, TUMOR; CARRIER PROTEINS; COLORECTAL NEOPLASMS; GENE EXPRESSION; HUMANS; MICROFILAMENT PROTEINS; MOLECULAR TARGETED THERAPY; UP-REGULATION;

EID: 84919933906     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2015.976557     Document Type: Article

References (69)

1. World Cancer Research Fund International. Available from: www.wcrf.org/cancer-statistics/data-specific-cancers/colorectal-cancer-statistics.php
2. Macmillan Cancer Support: the cancer survival lottery. 2011. Available from: www. macmillan.org.uk/Documents/AboutUs/Newsroom/LivingAfterCancerMedian CancerSurvivalTimes.pdf
3. Colon cancer survival rates UK. Available from: www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/colorectal-cancerstatistics
4. Sites of metastasis for colorectal cancers. Available from: www.cancer.gov/cancertopics/factsheet/Sites-Types/metastatic
5. Vogelstein B, Papadopoulos N, Velculescu VE, et al. Cancer genome landscapes. Science 2013;339:1546-58
6. Cano A, Mirna A, Pérez-Moreno MA, et al. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biol 2000;2:76-83
7. Findlay VJ, Wang C, Watson DK, Camp ER. Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer. Cancer Gene Ther 2014;21:181-7
8. Bertrand FE, Angus CW, Partis WJ, Sigounas G. Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch. Cell Cycle 2012;11:4344-51
9. Honda K, Yamada T, Hayashida Y, et al. Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Gastroenterology 2005;128:51-62
10. Gay F, Estornes Y, Saurin JC, et al. In colon carcinogenesis, the cytoskeletal protein gelsolin is down-regulated during the transition from adenoma to carcinoma. Hum Pathol 2008;39:1420-30
11. Lin Y, Buckhaults PJ, Lee JR, et al. Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer. Neoplasia 2009;11:864-73
12. Hashimoto Y, Kim DJ, Adams JC. The roles of fascins in health and disease. J Pathol 2011;224:289-00
13. Edwards RA, Bryan J. Fascins, a family of actin bundling proteins. Cell Motil Cytoskeleton 1995;32:1-9
14. Adams JC. Characterisation of cell-matrix adhesion requirements for the formation of fascin microspikes. Mol Biol Cell 1997;8: 2345-63
15. Elkhatib N, Neu MB, Zensen C, et al. Fascin plays a role in stress fiber organization and focal adhesion disassembly. Curr Biol 2014;24:1492-9
16. Svitkina TM, Bulanova EA, Chaga OY, et al. Mechanism of filopodia initiation by reorganization of a dendritic network. J Cell Biol 2003;160:409-21
17. Esue O, Harris ES, Higgs HN, et al. The filamentous actin crosslinking/bundling activity of mammalian formins. J Mol Biol 2008;384:324-34
18. Lee K, Gallop JL, Rambani K, et al. Self-assembly of filopodia-like structures on supported lipid bilayers. Science 2010;329: 1341-5
19. Jaiswal R, Breitsprecher D, Collins A, et al. The formin Daam1 and fascin directly collaborate to promote filopodia formation. Curr Biol 2013;23:1373-9
20. Winkelman JD, Bilancia CG, Peifer M, Kovar DR. Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with fascin. Proc Natl Acad Sci USA 2014;111:4121-6
21. Ali MY, Previs SB, Trybus KM, et al. Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection. Traffic 2013;14:70-81
22. Lee Y, Famouri P. Directional transport by nonprocessive motor proteins on fascin-cross-linked actin arrays. Nano Lett 2013;13:3775-82
23. Bao J, Huck D, Gunther LK, et al. Actin structure-dependent stepping of myosin 5a and 10 during processive movement. PLoS One 2013;8:e74936
24. Kerber ML, Jacobs DT, Campagnola L, et al. A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule level. Curr Biol 2009;19: 967-73
25. Breitsprecher D, Koestler SA, Chizhov I, et al. Cofilin cooperates with fascin to disassemble filopodial actin filaments. J Cell Sci 2011;124:3305-18
26. Chen L, Yang S, Jakoncic J, et al. Migrastatin analogues target fascin to block tumour metastasis. Nature 2010;464:1062-6.
27. Erratum in Nature 2011;476:240
28. Sedeh RS, Fedorov AA, Fedorov EV, et al. Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein. J Mol Biol 2010;400:589-04
29. Jansen S, Collins A, Yang C, et al. Mechanism of actin filament bundling by fascin. J Biol Chem 2011;286:30087-96
30. Yang S, Huang FK, Huang J, et al. Molecular mechanism of fascin function in filopodial formation. J Biol Chem 2013;288:274-84
31. Anilkumar N, Parsons M, Monk R, et al. Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. EMBO J 2003;22:5390-02
32. Zanet J, Jayo A, Plaza S, et al. Fascin promotes filopodia formation independent of its role in actin bundling. J Cell Biol 2012;197:477-86
33. Hashimoto Y, Parsons M, Adams JC. Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis. Mol Biol Cell 2007;18:4591-02
34. Parsons M, Adams JC. Rac regulates the interaction of fascin with protein kinase C in cell migration. J Cell Sci 2008;121: 2805-13
35. Jayo A, Parsons M, Adams JC. A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability. BMC Biol 2012;10:72
36. Jawhari AU, Buda A, Jenkins M, et al. Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro. Am J Pathol 2003;162:69-80
37. Vignjevic D, Schoumacher M, Gavert N. Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res 2007;67:6844-53
38. Schoumacher M, Goldman RD, Louvard D, Vignjevic DM. Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia. J Cell Biol 2010;189:541-56
39. Adams JC, Schwartz MA. Stimulation of fascin microspikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc 42. J Cell Biol 2000;150:807-22
40. Hashimoto Y, Loftis DW, Adams JC. Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells. PLoS ONE 2009;4: e5130
41. Li D, Jin L, Alesi GN, et al. The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. J Biol Chem 2013;288: 32528-38
42. Conacci-Sorrell M, Ngouenet C, Anderson S, et al. Stress-induced cleavage of Myc promotes cancer cell survival. Genes Dev 2014;28:689-07
43. Feng Y, Zhu J, Ou C, et al. MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1. Br J Cancer 2014;110:2300-9
44. Tan VY, Lewis SJ, Adams JC, Martin RM. Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis. BMC Med 2013;11:5
45. Kulasingam V, Diamandis EP. Fascin-1 is a novel biomarker of aggressiveness in some carcinomas. BMC Med 2013;11:53
46. Hashimoto Y, Skacel M, Lavery IC, et al. Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas. BMC Cancer 2006;6:241
47. Qualtrough D, Singh K, Banu N, et al. The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro. Br J Cancer 2009;101:1124-9
48. Puppa G, Maisonneuve P, Sonzogni A, et al. Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma. Br J Cancer 2007;96: 1118-26
49. Eaden J. Colorectal carcinoma and inflammatory bowel disease. Aliment Pharmacol Ther 2004;20(S4):24-30
50. Qualtrough D, Smallwood K, Littlejohns D, Pignatelli M. The actin-bundling protein fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair. BMC Gastroenterol 2011;11:14
51. Kanda Y, Kawaguchi T, Kuramitsu Y, et al. Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikis. Proteomics 2014;14:1031-41
52. Schrodt C, McHugh EE, Gawinowicz MA, et al. Rifaximin-mediated changes to the epithelial cell proteome: 2-D gel analysis. PLoS One 2013;8(7):e68550
53. Ling H, Fabbri M, Calin GA. Micro RNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov 2013;12:847-65
54. Lecomte N, Njardarson JT, Nagorny P, et al. Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin. Proc Natl Acad Sci USA 2011;108:15074-8
55. Lo Re D, Zhou Y, Nobis M, et al. Synthesis of migrastatin and its macroketone analogue and in vivo frap analysis of the macroketone on E-cadherin dynamics. ChemBioChem 2014;15:1459-64
56. Kraft R, Kahn A, Medina-Franco JL, et al. A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions. Dis Model Mech 2013;6:217-35
57. Zheng S, Zhong Q, Xi Y, et al. Modification and biological evaluation of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion. J Med Chem 2014;57(15): 6653-67
58. Hamers-Casterman C, Atarhouch T, Muyldermans S, et al. Naturally occurring antibodies devoid of light chains. Nature 1993;363:446-8
59. Van Audenhove I, Boucherie C, Pieters L, et al. Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalization. FASEB J 2014;28: 1805-18
60. Koçer NE, Kayaselçuk F. Is availability of anti-EGFR therapy for the colorectal adenocarcinomas showing fascin expression limited Target Oncol 2014;9:171-5
61. Kim MY, Oskarsson T, Acharyya S, et al. Tumor self-seeding by circulating cancer cells. Cell 2009;139:1315-26
62. Young M, Ordonez L, Clarke AR. What are the best routes to effectively model human colorectal cancer Mol Oncol 2013;7: 178-89
63. Byun AJ, Hung KE, Fleet JC, et al. Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. Cancer Lett 2014;347:191-5
64. Davies EJ, Marsh Durban V, Meniel V, et al. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. J Pathol 2014;233:27-38
65. Tsai WC, Chao YC, Sheu LF, et al. Overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parameters. Dis Markers 2007;23:153-60
66. Chan C, Jankova L, Fung CL, et al. Fascin expression predicts survival after potentially curative resection of node-positive colon cancer. Am J Surg Pathol 2010;34:656-66
67. Ozerhan IH, Ersoz N, Onguru O, et al. Fascin expression in colorectal carcinomas. Clinics (Sao Paulo) 2010;65157-64
68. Jung EJ, Lee JH, Min BW, et al. Clinicopathologic significance of fascin, extracellular matrix metalloproteinase inducer, and ezrin expressions in colorectal adenocarcinoma. Indian J Pathol Microbiol 2011;54:32-6
69. Oh SY, Kim YB, Suh KW, et al. Prognostic impact of fascin-1 expression is more significant in advanced colorectal cancer. J Surg Res 2012;172:102-8