PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine

Journal of Pathology

Volumn 233, Issue 1, 2014, Pages 27-38

  Davies, Emma J ^a   Marsh Durban, Victoria ^a   Meniel, Valerie ^a   Williams, Geraint T ^b   Clarke, Alan R ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

APC; colorectal cancer metastasis model; genetically engineered mouse model; KRAS; PTEN; serrated adenocarcinoma; serrated adenoma

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; GENE ACTIVATION; GENE DELETION; GENE INDUCTION; GENE MUTATION; GENETIC PREDISPOSITION; HISTOPATHOLOGY; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE CARCINOMA; INTESTINE EPITHELIUM; INTESTINE POLYP; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE K RAS; PRIORITY JOURNAL; PTEN GENE; SIGNAL TRANSDUCTION; TUMOR GROWTH; WILD TYPE;

APC; COLORECTAL CANCER METASTASIS MODEL; GENETICALLY ENGINEERED MOUSE MODEL; KRAS; PTEN; SERRATED ADENOCARCINOMA; SERRATED ADENOMA;

ADENOCARCINOMA; ADENOMA; ANIMALS; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; GENES, APC; GENETIC PREDISPOSITION TO DISEASE; HYPERPLASIA; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; INTESTINAL POLYPS; INTESTINE, SMALL; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; NEOPLASM INVASIVENESS; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR BURDEN;

EID: 84898596713     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4312     Document Type: Article

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