The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

British Journal of Cancer

Volumn 101, Issue 7, 2009, Pages 1124-1129

  Qualtrough, D ^a   Singh, K ^a   Banu, N ^a   Paraskeva, C ^a   Pignatelli, M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Adenoma; Colon; Fascin; Migration

Indexed keywords

FASCIN;

ADENOMA; ARTICLE; CANCER RISK; CELL MOTILITY; COLORECTAL ADENOMA; CONTROLLED STUDY; DYSPLASIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; POLYP; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VOLUME;

ADENOMA; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MICROFILAMENT PROTEINS;

EID: 70349666743     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605286     Document Type: Article

References (17)

1. Adams JC (2001) Cell matrix contact structures. Cell Mol Life Sci 58: 371-392
2. Brunton VG, Ozanne BW, Paraskeva C, Frame MC (1997) A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. Oncogene 14: 283-293 (Pubitemid 27073083)
3. Fogh J, Trempe G (1975) New human tumour cell lines. In Human tumour cells in vitro Fogh J (ed), pp 115-141. Plenum Press: New York
4. Hamilton S, Aaltonen L eds. (2001) Pathology and genetics of tumours of the digestive system (World health organisation classification of tumours). Oxford University Press: Oxford
5. Hashimoto Y, Skacel M, Adams JC (2005) Roles of fascin in human carcinoma motility and signalling: prospects for a novel biomarker. Int J Bioc Cell Biol 37: 1787-1804 (Pubitemid 40961664)
6. Hashimoto Y, Skacel M, Lavery IC, Mukherjee AL, Casey G, Adams JC (2006) Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas. BMC Cancer 6: 241 (Pubitemid 44687821)
7. Jawhari AU, Buda A, Jenkins M, Shehzad K, Sarraf C, Noda M, Farthing MJG, Pignatelli M, Adams JC (2003) Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro. Am J Path 162: 69-80 (Pubitemid 36041990)
8. Kureishy N, Sapountzi V, Prag S, Anilkumar N, Adams JC (2002) Fascins, and their roles in cell structure and function. Bioessays 24: 350-361 (Pubitemid 34305690)
9. Leibovitz A, Stinson JC, McCombs III WB, McCoy CE, Mazur KC, Mabry ND (1976) Classification of human colorectal adenocarcinoma cell lines. Cancer Res 36: 4562-4569
10. Matsudaira P (1994) Actin crosslinking proteins at the leading edge. Semin Cell Biol 5: 165-174
11. Muto T, Bussey HJ, Morson BC (1975) The evolution of cancer of the colon and rectum. Cancer 36: 2251-2270
12. Paraskeva C, Buckle BG, Sheer D, Wigley CB (1984) The isolation and characterisation of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients. Int J Cancer 34: 49-56 (Pubitemid 14095115)
13. Paraskeva C, Finerty S, Mountford RA, Powell SC (1989) Specific cytogenetic abnormalities in two new human colorectal adenoma-derived epithelial cell lines. Cancer Res 49: 1282-1286 (Pubitemid 19074850)
14. Puppa G, Maisonneuve P, Sonzogni A, Masullo M, Chiappa A, Valerio M, Zampino MG, Franceschetti I, Capelli P, Chilosi M, Menestrina F, Viale G, Pelosi G (2007) Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma. Br J Cancer 96: 1118-1126 (Pubitemid 46608324)
15. Qualtrough D, Kaidi A, Chell S, Jabbour HN, Williams AC, Paraskeva C (2007) Prostaglandin F2(alpha) stimulates motility and invasion in colorectal tumor cells. Int J Cancer 121: 734-740
16. Sporn MB (1996) The war on cancer. Lancet 347: 1377-1381
17. Young A, Rea D (2000) ABC of colorectal cancer: treatment of advanced disease. Br Med J 321: 1278-1281 (Pubitemid 30943647)